Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 221 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| ICAM2 | ENSG00000108622 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.25 | 0.00 | 0.03 | 0.00 | 0.12 | 0.00 | 0.14 | 0.01 | 0.20 | 0.01 | 0.07 | 0.02 | 0.20 | 0.02 | 0.11 | 0.02 | 0.07 | 0.01 | 0.07 | 0.02 | 0.08 | 0.10 | 0.20 | 0.00 | 0.12 | 0.01 | 0.19 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.57 | 0.01 | 0.24 | 0.03 | 0.17 | 0.02 | 0.10 | 0.03 | 0.27 | 0.02 | 0.17 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.06 | 0.00 | 0.03 | 0.01 | 0.16 | 0.00 | 0.24 | 0.01 |
| FBN1 | ENSG00000166147 | 0.00 | 0.00 | 0.00 | 0.01 | 0.14 | 0.00 | 0.01 | 0.05 | 0.03 | 0.05 | 0.00 | 0.00 | 0.02 | 0.22 | 0.01 | 0.07 | 0.03 | 0.06 | 0.02 | 0.03 | 0.02 | 0.05 | 0.01 | 0.06 | 0.01 | 0.04 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.01 | 0.02 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.08 | 0.06 | 0.23 | 0.00 | 0.10 | 0.00 | 0.07 | 0.08 | 0.29 | 0.08 | 0.07 | 0.01 | 0.03 | 0.00 | 0.00 | 0.02 | 0.05 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.00 | 0.01 | 0.13 |
| FCRLA | ENSG00000132185 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.78 | 0.01 | 0.02 | 0.00 | 0.10 | 0.01 | 0.28 | 0.00 | 0.27 | 0.00 | 0.05 | 0.00 | 0.29 | 0.01 | 0.13 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.06 | 0.00 | 0.30 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.31 | 0.00 | 0.37 | 0.02 | 0.16 | 0.00 | 0.13 | 0.00 | 0.28 | 0.00 | 0.34 | 0.03 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.18 | 0.01 |
| PYGL | ENSG00000100504 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.05 | 0.14 | 0.02 | 0.06 | 0.04 | 0.06 | 0.02 | 0.14 | 0.00 | 0.09 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.04 | 0.04 | 0.05 | 0.11 | 0.04 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.12 | 0.03 | 0.12 | 0.12 | 0.03 | 0.00 | 0.03 | 0.01 | 0.05 | 0.03 | 0.03 | 0.10 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.02 | 0.01 | 0.04 | 0.00 | 0.00 | 0.02 | 0.04 |
| CNGB1 | ENSG00000070729 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.03 | 0.04 | 0.01 | 0.03 | 0.03 | 0.10 | 0.02 | 0.03 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.02 | 0.00 | 0.01 | 0.06 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.04 | 0.04 | 0.15 | 0.00 | 0.07 | 0.03 | 0.07 | 0.02 | 0.13 | 0.02 | 0.05 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.03 | 0.04 |
| MCOLN2 | ENSG00000153898 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.05 | 0.07 | 0.00 | 0.00 | 0.00 | 0.29 | 0.04 | 0.08 | 0.04 | 0.05 | 0.01 | 0.07 | 0.01 | 0.07 | 0.02 | 0.06 | 0.00 | 0.07 | 0.01 | 0.07 | 0.00 | 0.01 | 0.03 | 0.03 | 0.00 | 0.08 | 0.04 | 0.04 | 0.00 | 0.21 | 0.00 | 0.00 | 0.05 | 0.10 | 0.11 | 0.20 | 0.01 | 0.04 | 0.02 | 0.03 | 0.13 | 0.05 | 0.14 | 0.06 | 0.03 | 0.05 | 0.01 | 0.01 | 0.10 | 0.00 | 0.01 | 0.01 | 0.02 | 0.04 | 0.03 | 0.03 | 0.05 | 0.10 |
| ACTN4 | ENSG00000130402 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.02 | 0.02 | 0.32 | 0.02 | 0.00 | 0.00 | 0.08 | 0.03 | 0.20 | 0.03 | 0.55 | 0.03 | 0.07 | 0.01 | 0.14 | 0.04 | 0.12 | 0.02 | 0.05 | 0.01 | 0.02 | 0.01 | 0.20 | 0.00 | 0.04 | 0.01 | 0.12 | 0.01 | 0.05 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.14 | 0.03 | 0.72 | 0.12 | 0.28 | 0.03 | 0.18 | 0.03 | 1.24 | 0.11 | 0.27 | 0.11 | 0.00 | 0.03 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.04 | 0.05 | 0.04 | 0.00 | 0.00 | 0.04 | 0.02 |
| ZCWPW1 | ENSG00000078487 | 0.02 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.12 | 0.01 | 0.22 | 0.02 | 0.22 | 0.00 | 0.50 | 0.02 | 0.27 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.10 | 0.01 | 0.08 | 0.02 | 0.14 | 0.01 | 0.11 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.03 | 0.23 | 0.05 | 0.08 | 0.01 | 0.08 | 0.02 | 0.15 | 0.03 | 0.06 | 0.04 | 0.06 | 0.01 | 0.00 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.04 | 0.03 |
| SSH3 | ENSG00000172830 | 0.01 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.11 | 0.00 | 0.22 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.14 | 0.01 | 0.19 | 0.01 | 0.43 | 0.00 | 0.43 | 0.02 | 0.19 | 0.02 | 0.01 | 0.01 | 0.04 | 0.02 | 0.02 | 0.01 | 0.13 | 0.01 | 0.20 | 0.02 | 0.08 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.47 | 0.03 | 0.27 | 0.02 | 0.20 | 0.00 | 0.17 | 0.02 | 0.27 | 0.02 | 0.13 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.18 | 0.02 |
| NR1H3 | ENSG00000025434 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.09 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.02 | 0.10 | 0.03 | 0.06 | 0.01 | 0.08 | 0.05 | 0.06 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.07 | 0.16 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.07 | 0.07 | 0.03 | 0.07 | 0.02 | 0.13 | 0.15 | 0.09 | 0.09 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.02 | 0.01 | 0.04 |
| CPB2 | ENSG00000080618 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.41 | 0.02 | 0.26 | 0.00 | 0.00 | 0.00 | 0.16 | 0.02 | 0.07 | 0.02 | 0.11 | 0.01 | 0.14 | 0.03 | 0.09 | 0.12 | 0.04 | 0.10 | 0.04 | 0.15 | 0.03 | 0.01 | 0.01 | 0.00 | 0.28 | 0.00 | 0.11 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.13 | 0.04 | 0.22 | 0.00 | 0.22 | 0.00 | 0.04 | 0.08 | 0.14 | 0.03 | 0.36 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.06 | 0.01 | 0.07 | 0.00 | 0.13 | 0.00 | 0.00 | 0.01 | 0.04 |
| RORA | ENSG00000069667 | 0.00 | 0.00 | 0.00 | 0.01 | 0.14 | 0.03 | 0.01 | 0.02 | 0.01 | 0.06 | 0.00 | 0.00 | 0.08 | 0.00 | 0.02 | 0.04 | 0.04 | 0.05 | 0.02 | 0.03 | 0.03 | 0.07 | 0.02 | 0.04 | 0.01 | 0.03 | 0.00 | 0.05 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.01 | 0.06 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.06 | 0.10 | 0.16 | 0.04 | 0.04 | 0.02 | 0.07 | 0.04 | 0.24 | 0.15 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.06 | 0.02 | 0.01 | 0.02 | 0.01 | 0.06 | 0.00 | 0.00 | 0.05 | 0.03 |
| DPF3 | ENSG00000205683 | 0.01 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.05 | 0.05 | 0.00 | 0.01 | 0.00 | 0.06 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.01 | 0.05 | 0.04 | 0.02 | 0.05 | 0.00 | 0.03 | 0.01 | 0.03 | 0.01 | 0.01 | 0.01 | 0.09 | 0.00 | 0.33 | 0.02 | 0.05 | 0.03 | 0.04 | 0.00 | 0.00 | 0.01 | 0.10 | 0.08 | 0.23 | 0.06 | 0.02 | 0.01 | 0.02 | 0.09 | 0.04 | 0.05 | 0.12 | 0.03 | 0.01 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.11 | 0.01 | 0.08 | 0.03 | 0.00 | 0.00 | 0.06 |
| OBSCN | ENSG00000154358 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.10 | 0.05 | 0.02 | 0.02 | 0.05 | 0.03 | 0.08 | 0.01 | 0.12 | 0.02 | 0.05 | 0.00 | 0.20 | 0.05 | 0.10 | 0.02 | 0.03 | 0.02 | 0.05 | 0.01 | 0.01 | 0.01 | 0.14 | 0.02 | 0.23 | 0.02 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.23 | 0.02 | 0.42 | 0.05 | 0.08 | 0.01 | 0.10 | 0.02 | 0.23 | 0.00 | 0.03 | 0.23 | 0.04 | 0.05 | 0.02 | 0.00 | 0.02 | 0.15 | 0.01 | 0.03 | 0.02 | 0.05 | 0.09 | 0.03 | 0.13 | 0.05 |
| PTK2B | ENSG00000120899 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.20 | 0.01 | 0.11 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.06 | 0.01 | 0.09 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.18 | 0.00 | 0.04 | 0.02 | 0.11 | 0.00 | 0.08 | 0.14 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.04 | 0.14 | 0.04 | 0.40 | 0.00 | 0.03 | 0.01 | 0.11 | 0.14 | 0.21 | 0.07 | 0.07 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.05 |
| CYP46A1 | ENSG00000036530 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.04 | 0.02 | 0.04 | 0.07 | 0.06 | 0.00 | 0.00 | 0.00 | 0.07 | 0.04 | 0.06 | 0.18 | 0.02 | 0.07 | 0.05 | 0.09 | 0.04 | 0.03 | 0.06 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.10 | 0.00 | 0.31 | 0.11 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.06 | 0.07 | 0.22 | 0.17 | 0.06 | 0.10 | 0.05 | 0.02 | 0.20 | 0.05 | 0.10 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.08 | 0.02 | 0.06 | 0.03 | 0.01 | 0.01 | 0.06 |
| PLCB3 | ENSG00000149782 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.03 | 0.01 | 0.12 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.06 | 0.03 | 0.08 | 0.02 | 0.19 | 0.03 | 0.11 | 0.05 | 0.02 | 0.03 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.03 | 0.02 | 0.03 | 0.13 | 0.07 | 0.07 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 0.09 | 0.16 | 0.05 | 0.08 | 0.01 | 0.10 | 0.03 | 0.55 | 0.08 | 0.07 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.05 |
| NRXN3 | ENSG00000021645 | 0.01 | 0.04 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.04 | 0.05 | 0.04 | 0.00 | 0.00 | 0.01 | 0.09 | 0.04 | 0.05 | 0.07 | 0.03 | 0.03 | 0.02 | 0.08 | 0.05 | 0.03 | 0.04 | 0.00 | 0.04 | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 | 0.09 | 0.00 | 0.33 | 0.17 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.10 | 0.15 | 0.18 | 0.06 | 0.08 | 0.04 | 0.02 | 0.06 | 0.19 | 0.09 | 0.14 | 0.03 | 0.02 | 0.00 | 0.00 | 0.04 | 0.03 | 0.00 | 0.11 | 0.01 | 0.08 | 0.03 | 0.00 | 0.01 | 0.07 |
| CERK | ENSG00000100422 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.04 | 0.02 | 0.10 | 0.00 | 0.04 | 0.00 | 0.04 | 0.03 | 0.11 | 0.05 | 0.07 | 0.04 | 0.04 | 0.05 | 0.03 | 0.02 | 0.08 | 0.01 | 0.02 | 0.01 | 0.10 | 0.01 | 0.08 | 0.07 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.05 | 0.06 | 0.05 | 0.53 | 0.03 | 0.06 | 0.04 | 0.12 | 0.07 | 0.27 | 0.04 | 0.15 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.05 | 0.01 | 0.10 | 0.00 | 0.00 | 0.17 | 0.04 |
| KCNC4 | ENSG00000116396 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.05 | 0.06 | 0.00 | 0.00 | 0.00 | 0.35 | 0.01 | 0.13 | 0.01 | 0.14 | 0.00 | 0.12 | 0.06 | 0.12 | 0.03 | 0.07 | 0.00 | 0.06 | 0.00 | 0.07 | 0.00 | 0.02 | 0.02 | 0.03 | 0.00 | 0.10 | 0.06 | 0.04 | 0.00 | 0.26 | 0.00 | 0.00 | 0.04 | 0.10 | 0.15 | 0.15 | 0.01 | 0.07 | 0.02 | 0.03 | 0.06 | 0.06 | 0.05 | 0.11 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.08 | 0.10 |
|
Showing page 221 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.