Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 201 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| TG | ENSG00000042832 | 0.02 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.08 | 0.02 | 0.21 | 0.03 | 0.02 | 0.00 | 0.10 | 0.02 | 0.29 | 0.01 | 0.34 | 0.00 | 0.29 | 0.00 | 0.49 | 0.01 | 0.21 | 0.02 | 0.18 | 0.01 | 0.22 | 0.01 | 0.16 | 0.00 | 0.38 | 0.01 | 0.25 | 0.01 | 0.10 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.48 | 0.03 | 1.62 | 0.03 | 0.20 | 0.00 | 0.18 | 0.01 | 0.37 | 0.03 | 0.15 | 0.06 | 0.03 | 0.02 | 0.02 | 0.00 | 0.19 | 0.05 | 0.18 | 0.01 | 0.03 | 0.02 | 0.56 | 0.00 | 0.22 | 0.01 |
| FGF9 | ENSG00000102678 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.05 | 0.08 | 0.06 | 0.00 | 0.00 | 0.00 | 0.14 | 0.01 | 0.12 | 0.03 | 0.13 | 0.01 | 0.18 | 0.07 | 0.14 | 0.10 | 0.05 | 0.18 | 0.00 | 0.28 | 0.03 | 0.00 | 0.01 | 0.04 | 0.11 | 0.00 | 0.15 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.01 | 0.07 | 0.09 | 0.07 | 0.21 | 0.03 | 0.15 | 0.02 | 0.06 | 0.01 | 0.22 | 0.15 | 0.17 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.06 | 0.01 | 0.07 | 0.00 | 0.00 | 0.06 | 0.05 |
| NOX4 | ENSG00000086991 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.03 | 0.03 | 0.02 | 0.10 | 0.05 | 0.00 | 0.00 | 0.06 | 0.06 | 0.12 | 0.02 | 0.10 | 0.05 | 0.12 | 0.07 | 0.17 | 0.04 | 0.04 | 0.03 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.01 | 0.03 | 0.04 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.12 | 0.10 | 0.39 | 0.07 | 0.14 | 0.06 | 0.07 | 0.04 | 0.06 | 0.19 | 0.07 | 0.10 | 0.04 | 0.07 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.10 | 0.07 |
| KL | ENSG00000133116 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.17 | 0.12 | 0.11 | 0.00 | 0.02 | 0.00 | 0.18 | 0.02 | 0.08 | 0.02 | 0.11 | 0.02 | 0.15 | 0.17 | 0.06 | 0.18 | 0.03 | 0.14 | 0.01 | 0.19 | 0.03 | 0.00 | 0.01 | 0.01 | 0.15 | 0.00 | 0.14 | 0.00 | 0.07 | 0.04 | 0.00 | 0.00 | 0.01 | 0.06 | 0.11 | 0.07 | 0.19 | 0.03 | 0.16 | 0.01 | 0.05 | 0.01 | 0.15 | 0.07 | 0.30 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.10 | 0.01 | 0.07 | 0.00 | 0.08 | 0.00 | 0.00 | 0.08 | 0.03 |
| RNASEH1 | ENSG00000171865 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.06 | 0.02 | 0.01 | 0.15 | 0.03 | 0.00 | 0.00 | 0.03 | 0.04 | 0.05 | 0.02 | 0.10 | 0.05 | 0.03 | 0.04 | 0.07 | 0.06 | 0.04 | 0.04 | 0.01 | 0.01 | 0.03 | 0.04 | 0.01 | 0.03 | 0.13 | 0.02 | 0.00 | 0.05 | 0.03 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.30 | 0.17 | 0.08 | 0.01 | 0.10 | 0.04 | 0.31 | 0.07 | 0.04 | 0.12 | 0.14 | 0.01 | 0.00 | 0.00 | 0.02 | 0.08 | 0.02 | 0.02 | 0.02 | 0.02 | 0.05 | 0.00 | 0.02 | 0.03 |
| KCNC3 | ENSG00000131398 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.11 | 0.04 | 0.00 | 0.02 | 0.00 | 0.06 | 0.01 | 0.07 | 0.07 | 0.11 | 0.03 | 0.02 | 0.06 | 0.03 | 0.08 | 0.03 | 0.01 | 0.03 | 0.02 | 0.03 | 0.03 | 0.05 | 0.05 | 0.04 | 0.00 | 0.07 | 0.23 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.10 | 0.04 | 0.05 | 0.32 | 0.06 | 0.07 | 0.04 | 0.06 | 0.15 | 0.15 | 0.03 | 0.18 | 0.00 | 0.04 | 0.01 | 0.00 | 0.13 | 0.03 | 0.00 | 0.15 | 0.02 | 0.13 | 0.00 | 0.00 | 0.03 | 0.02 |
| SPNS1 | ENSG00000169682 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.19 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.07 | 0.01 | 0.09 | 0.01 | 0.03 | 0.01 | 0.06 | 0.00 | 0.04 | 0.00 | 0.03 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.08 | 0.03 | 0.02 | 0.03 | 0.09 | 0.01 | 0.34 | 0.03 | 0.05 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 |
| CLCN2 | ENSG00000114859 | 0.05 | 0.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.03 | 0.03 | 0.17 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.15 | 0.05 | 1.84 | 0.00 | 0.65 | 0.00 | 0.71 | 0.02 | 0.23 | 0.01 | 0.04 | 0.00 | 0.06 | 0.03 | 0.03 | 0.01 | 0.11 | 0.02 | 0.12 | 0.01 | 0.10 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.19 | 0.02 | 1.12 | 0.02 | 0.62 | 0.00 | 0.35 | 0.01 | 0.76 | 0.09 | 0.12 | 0.10 | 0.22 | 0.00 | 0.00 | 0.01 | 0.06 | 0.00 | 0.06 | 0.00 | 0.20 | 0.02 | 0.00 | 0.00 | 0.03 | 0.05 |
| PMP2 | ENSG00000147588 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.00 | 0.09 | 0.01 | 0.15 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.01 | 0.13 | 0.02 | 0.06 | 0.00 | 0.13 | 0.01 | 0.12 | 0.00 | 0.11 | 0.00 | 0.16 | 0.01 | 0.01 | 0.01 | 0.12 | 0.00 | 0.19 | 0.01 | 0.06 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.27 | 0.01 | 0.25 | 0.10 | 0.04 | 0.01 | 0.05 | 0.01 | 0.15 | 0.02 | 0.19 | 0.05 | 0.14 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.22 | 0.00 | 0.12 | 0.01 |
| TMX2 | ENSG00000213593 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.14 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.03 | 0.08 | 0.02 | 0.10 | 0.02 | 0.09 | 0.04 | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.03 | 0.02 | 0.03 | 0.00 | 0.12 | 0.04 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.13 | 0.07 | 0.10 | 0.05 | 0.07 | 0.02 | 0.06 | 0.02 | 0.34 | 0.11 | 0.06 | 0.04 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 |
| COL9A3 | ENSG00000092758 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.06 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.28 | 0.01 | 0.07 | 0.04 | 0.02 | 0.01 | 0.11 | 0.01 | 0.16 | 0.00 | 0.09 | 0.00 | 0.12 | 0.01 | 0.03 | 0.00 | 0.11 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.35 | 0.02 | 0.48 | 0.04 | 0.04 | 0.03 | 0.12 | 0.01 | 0.17 | 0.00 | 0.19 | 0.06 | 0.02 | 0.02 | 0.03 | 0.00 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.12 | 0.00 |
| KCNK2 | ENSG00000082482 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.07 | 0.07 | 0.06 | 0.02 | 0.00 | 0.05 | 0.05 | 0.09 | 0.02 | 0.10 | 0.02 | 0.06 | 0.00 | 0.17 | 0.04 | 0.06 | 0.01 | 0.03 | 0.01 | 0.09 | 0.05 | 0.00 | 0.02 | 0.13 | 0.02 | 0.16 | 0.02 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.21 | 0.02 | 0.20 | 0.16 | 0.06 | 0.01 | 0.06 | 0.03 | 0.15 | 0.04 | 0.02 | 0.21 | 0.02 | 0.03 | 0.01 | 0.00 | 0.15 | 0.06 | 0.00 | 0.02 | 0.01 | 0.06 | 0.09 | 0.00 | 0.14 | 0.03 |
| GRIK4 | ENSG00000149403 | 0.01 | 0.01 | 0.00 | 0.05 | 0.02 | 0.02 | 0.02 | 0.08 | 0.03 | 0.11 | 0.00 | 0.00 | 0.11 | 0.04 | 0.05 | 0.09 | 0.05 | 0.08 | 0.06 | 0.15 | 0.05 | 0.14 | 0.06 | 0.07 | 0.00 | 0.02 | 0.01 | 0.04 | 0.01 | 0.02 | 0.04 | 0.10 | 0.00 | 0.17 | 0.00 | 0.05 | 0.01 | 0.06 | 0.00 | 0.00 | 0.02 | 0.22 | 0.19 | 0.16 | 0.07 | 0.31 | 0.05 | 0.06 | 0.09 | 0.17 | 0.03 | 0.25 | 0.00 | 0.19 | 0.03 | 0.00 | 0.08 | 0.05 | 0.06 | 0.01 | 0.03 | 0.01 | 0.00 | 0.07 | 0.01 | 0.28 |
| GALK1 | ENSG00000108479 | 0.02 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.04 | 0.03 | 0.21 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.15 | 0.01 | 0.26 | 0.02 | 0.10 | 0.03 | 0.23 | 0.07 | 0.10 | 0.04 | 0.04 | 0.01 | 0.06 | 0.02 | 0.04 | 0.10 | 0.26 | 0.00 | 0.08 | 0.01 | 0.14 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.37 | 0.03 | 0.34 | 0.03 | 0.23 | 0.02 | 0.23 | 0.01 | 0.71 | 0.00 | 0.25 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.09 | 0.00 | 0.07 | 0.01 | 0.14 | 0.01 | 0.24 | 0.02 |
| MARK2 | ENSG00000072518 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.03 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.12 | 0.00 | 0.06 | 0.02 | 0.08 | 0.01 | 0.20 | 0.02 | 0.12 | 0.03 | 0.03 | 0.03 | 0.02 | 0.02 | 0.03 | 0.03 | 0.00 | 0.03 | 0.02 | 0.03 | 0.14 | 0.07 | 0.11 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 0.08 | 0.17 | 0.04 | 0.08 | 0.01 | 0.16 | 0.01 | 0.61 | 0.16 | 0.09 | 0.02 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.04 |
| HIPK1 | ENSG00000163349 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.31 | 0.01 | 0.14 | 0.02 | 0.16 | 0.00 | 0.15 | 0.05 | 0.19 | 0.05 | 0.08 | 0.00 | 0.07 | 0.06 | 0.08 | 0.01 | 0.02 | 0.03 | 0.03 | 0.00 | 0.11 | 0.02 | 0.05 | 0.00 | 0.26 | 0.00 | 0.00 | 0.03 | 0.09 | 0.16 | 0.14 | 0.01 | 0.08 | 0.02 | 0.03 | 0.06 | 0.06 | 0.03 | 0.12 | 0.05 | 0.04 | 0.00 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.05 | 0.12 | 0.10 |
| SERPINB7 | ENSG00000166396 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.01 | 0.09 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.09 | 0.05 | 0.06 | 0.03 | 0.14 | 0.06 | 0.19 | 0.02 | 0.16 | 0.00 | 0.12 | 0.01 | 0.11 | 0.01 | 0.08 | 0.02 | 0.06 | 0.00 | 0.10 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.05 | 0.07 | 0.33 | 0.01 | 0.03 | 0.00 | 0.07 | 0.01 | 0.11 | 0.10 | 0.07 | 0.00 | 0.07 | 0.00 | 0.00 | 0.10 | 0.00 | 0.01 | 0.02 | 0.00 | 0.04 | 0.00 | 0.01 | 0.03 | 0.01 |
| CEL | ENSG00000170835 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.05 | 0.02 | 0.07 | 0.03 | 0.07 | 0.03 | 0.12 | 0.04 | 0.12 | 0.01 | 0.02 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.05 | 0.03 | 0.06 | 0.01 | 0.12 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.07 | 0.24 | 0.07 | 0.01 | 0.03 | 0.05 | 0.03 | 0.14 | 0.04 | 0.14 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 |
| PIK3R5 | ENSG00000141506 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.12 | 0.04 | 0.05 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.06 | 0.03 | 0.02 | 0.02 | 0.02 | 0.03 | 0.05 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.15 | 0.02 | 0.08 | 0.01 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.06 | 0.05 | 0.11 | 0.00 | 0.05 | 0.05 | 0.06 | 0.06 | 0.15 | 0.32 | 0.19 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.03 |
| HP | ENSG00000257017 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.21 | 0.15 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.02 | 0.06 | 0.04 | 0.05 | 0.04 | 0.01 | 0.01 | 0.02 | 0.03 | 0.01 | 0.00 | 0.02 | 0.05 | 0.05 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.03 | 0.33 | 0.04 | 0.03 | 0.03 | 0.09 | 0.00 | 0.16 | 0.03 | 0.04 | 0.05 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.04 | 0.02 |
|
Showing page 201 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.