Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 20 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SRPX2 | ENSG00000102359 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.06 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.07 | 0.02 | 0.04 | 0.01 | 0.14 | 0.02 | 0.05 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.05 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 0.08 | 0.10 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 |
| GLA | ENSG00000102393 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.09 | 0.01 | 0.04 | 0.01 | 0.08 | 0.02 | 0.03 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.04 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 0.09 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 |
| ACP5 | ENSG00000102575 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.07 | 0.04 | 0.00 | 0.01 | 0.11 | 0.01 | 0.01 | 0.05 | 0.08 | 0.06 | 0.05 | 0.04 | 0.06 | 0.05 | 0.06 | 0.02 | 0.02 | 0.01 | 0.02 | 0.04 | 0.01 | 0.03 | 0.03 | 0.09 | 0.00 | 0.01 | 0.12 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.58 | 0.19 | 0.09 | 0.04 | 0.22 | 0.03 | 0.24 | 0.18 | 0.23 | 0.01 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.02 |
| SLC25A15 | ENSG00000102743 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.36 | 0.05 | 0.23 | 0.00 | 0.02 | 0.00 | 0.16 | 0.02 | 0.08 | 0.02 | 0.11 | 0.01 | 0.15 | 0.16 | 0.05 | 0.17 | 0.03 | 0.14 | 0.02 | 0.16 | 0.04 | 0.01 | 0.01 | 0.01 | 0.21 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.14 | 0.04 | 0.24 | 0.01 | 0.22 | 0.01 | 0.05 | 0.07 | 0.23 | 0.07 | 0.27 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.06 | 0.01 | 0.06 | 0.00 | 0.11 | 0.00 | 0.00 | 0.03 | 0.03 |
| FLT1 | ENSG00000102755 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.05 | 0.12 | 0.04 | 0.00 | 0.02 | 0.00 | 0.18 | 0.03 | 0.08 | 0.03 | 0.12 | 0.02 | 0.14 | 0.10 | 0.07 | 0.10 | 0.04 | 0.27 | 0.00 | 0.54 | 0.02 | 0.01 | 0.01 | 0.03 | 0.14 | 0.00 | 0.15 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 0.01 | 0.11 | 0.06 | 0.05 | 0.18 | 0.03 | 0.14 | 0.01 | 0.05 | 0.01 | 0.14 | 0.09 | 0.24 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.09 | 0.01 | 0.05 | 0.01 | 0.07 | 0.00 | 0.00 | 0.06 | 0.03 |
| MAPK3 | ENSG00000102882 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.17 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.01 | 0.09 | 0.01 | 0.03 | 0.01 | 0.12 | 0.00 | 0.05 | 0.00 | 0.05 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.01 | 0.12 | 0.03 | 0.02 | 0.02 | 0.10 | 0.01 | 0.34 | 0.05 | 0.04 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 |
| CBLN1 | ENSG00000102924 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.04 | 0.08 | 0.03 | 0.05 | 0.02 | 0.03 | 0.03 | 0.09 | 0.01 | 0.02 | 0.04 | 0.04 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.08 | 0.05 | 0.04 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.05 | 0.10 | 0.13 | 0.01 | 0.07 | 0.03 | 0.04 | 0.02 | 0.14 | 0.02 | 0.13 | 0.08 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.01 | 0.06 |
| CCL22 | ENSG00000102962 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.09 | 0.01 | 0.03 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.04 | 0.05 | 0.13 | 0.00 | 0.07 | 0.04 | 0.06 | 0.02 | 0.12 | 0.02 | 0.06 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.04 |
| DHODH | ENSG00000102967 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.20 | 0.15 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.02 | 0.07 | 0.04 | 0.05 | 0.03 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.00 | 0.02 | 0.06 | 0.05 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.03 | 0.32 | 0.04 | 0.03 | 0.03 | 0.09 | 0.00 | 0.16 | 0.03 | 0.06 | 0.05 | 0.04 | 0.01 | 0.04 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.04 | 0.02 |
| CCL17 | ENSG00000102970 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.09 | 0.01 | 0.03 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.04 | 0.05 | 0.14 | 0.00 | 0.07 | 0.04 | 0.06 | 0.05 | 0.12 | 0.02 | 0.06 | 0.12 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.04 |
| POLR2C | ENSG00000102978 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.09 | 0.01 | 0.03 | 0.03 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.07 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.04 | 0.05 | 0.14 | 0.00 | 0.07 | 0.04 | 0.06 | 0.03 | 0.16 | 0.02 | 0.06 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.00 | 0.04 |
| PRSS54 | ENSG00000103023 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.10 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.06 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.04 | 0.04 | 0.15 | 0.00 | 0.06 | 0.02 | 0.07 | 0.00 | 0.16 | 0.03 | 0.05 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.03 | 0.02 | 0.04 |
| PSMD7 | ENSG00000103035 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.22 | 0.12 | 0.02 | 0.00 | 0.00 | 0.00 | 0.12 | 0.05 | 0.05 | 0.04 | 0.04 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.00 | 0.01 | 0.05 | 0.05 | 0.01 | 0.07 | 0.07 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.06 | 0.03 | 0.29 | 0.04 | 0.02 | 0.03 | 0.08 | 0.01 | 0.22 | 0.03 | 0.06 | 0.01 | 0.07 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.03 | 0.04 |
| SETD6 | ENSG00000103037 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.10 | 0.01 | 0.02 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.06 | 0.06 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.04 | 0.05 | 0.16 | 0.00 | 0.06 | 0.03 | 0.07 | 0.00 | 0.16 | 0.03 | 0.06 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.03 | 0.02 | 0.04 |
| HAS3 | ENSG00000103044 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.01 | 0.10 | 0.15 | 0.03 | 0.00 | 0.00 | 0.00 | 0.09 | 0.05 | 0.04 | 0.04 | 0.03 | 0.03 | 0.02 | 0.11 | 0.04 | 0.04 | 0.03 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.04 | 0.09 | 0.01 | 0.21 | 0.03 | 0.02 | 0.01 | 0.00 | 0.01 | 0.03 | 0.05 | 0.03 | 0.33 | 0.03 | 0.04 | 0.02 | 0.09 | 0.08 | 0.14 | 0.02 | 0.05 | 0.12 | 0.03 | 0.01 | 0.04 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.05 | 0.01 |
| HSDL1 | ENSG00000103160 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.08 | 0.00 | 0.28 | 0.09 | 0.05 | 0.00 | 0.00 | 0.01 | 0.17 | 0.01 | 0.09 | 0.04 | 0.08 | 0.03 | 0.04 | 0.06 | 0.04 | 0.03 | 0.04 | 0.01 | 0.03 | 0.02 | 0.04 | 0.01 | 0.02 | 0.00 | 0.06 | 0.05 | 0.01 | 0.06 | 0.07 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.08 | 0.05 | 0.33 | 0.03 | 0.04 | 0.01 | 0.08 | 0.01 | 0.24 | 0.05 | 0.08 | 0.00 | 0.12 | 0.00 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.00 | 0.01 | 0.09 |
| WFDC1 | ENSG00000103175 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.08 | 0.00 | 0.28 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.09 | 0.03 | 0.08 | 0.03 | 0.04 | 0.06 | 0.04 | 0.03 | 0.04 | 0.01 | 0.03 | 0.02 | 0.04 | 0.02 | 0.02 | 0.00 | 0.06 | 0.05 | 0.01 | 0.06 | 0.05 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.08 | 0.05 | 0.33 | 0.03 | 0.04 | 0.01 | 0.08 | 0.01 | 0.27 | 0.06 | 0.07 | 0.00 | 0.10 | 0.00 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.00 | 0.01 | 0.09 |
| CRISPLD2 | ENSG00000103196 | 0.01 | 0.00 | 0.00 | 0.04 | 0.00 | 0.08 | 0.00 | 0.28 | 0.08 | 0.05 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.09 | 0.03 | 0.08 | 0.03 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.01 | 0.03 | 0.02 | 0.04 | 0.02 | 0.02 | 0.01 | 0.06 | 0.05 | 0.01 | 0.06 | 0.05 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.08 | 0.04 | 0.33 | 0.03 | 0.04 | 0.01 | 0.08 | 0.01 | 0.27 | 0.07 | 0.07 | 0.00 | 0.10 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 | 0.04 | 0.00 | 0.00 | 0.02 | 0.09 |
| METRN | ENSG00000103260 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.03 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.06 | 0.05 | 0.05 | 0.09 | 0.03 | 0.03 | 0.02 | 0.14 | 0.05 | 0.09 | 0.04 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.05 | 0.06 | 0.00 | 0.05 | 0.14 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.03 | 0.16 | 0.22 | 0.10 | 0.06 | 0.09 | 0.05 | 0.11 | 0.21 | 0.09 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 |
| MEFV | ENSG00000103313 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.18 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.03 | 0.10 | 0.04 | 0.02 | 0.02 | 0.08 | 0.02 | 0.08 | 0.03 | 0.03 | 0.02 | 0.03 | 0.02 | 0.02 | 0.03 | 0.02 | 0.05 | 0.05 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.08 | 0.19 | 0.10 | 0.02 | 0.04 | 0.05 | 0.07 | 0.05 | 0.09 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.06 | 0.02 |
|
Showing page 20 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.