Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 192 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| LIG1 | ENSG00000105486 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.07 | 0.04 | 0.00 | 0.02 | 0.00 | 0.08 | 0.01 | 0.08 | 0.04 | 0.10 | 0.02 | 0.02 | 0.08 | 0.05 | 0.05 | 0.03 | 0.01 | 0.02 | 0.01 | 0.04 | 0.03 | 0.05 | 0.04 | 0.04 | 0.00 | 0.07 | 0.18 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.05 | 0.05 | 0.33 | 0.06 | 0.07 | 0.03 | 0.06 | 0.11 | 0.22 | 0.02 | 0.19 | 0.00 | 0.04 | 0.01 | 0.00 | 0.07 | 0.03 | 0.01 | 0.13 | 0.02 | 0.13 | 0.00 | 0.00 | 0.02 | 0.03 |
| MSLN | ENSG00000102854 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.03 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.06 | 0.05 | 0.05 | 0.09 | 0.03 | 0.03 | 0.02 | 0.14 | 0.05 | 0.09 | 0.04 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.05 | 0.06 | 0.00 | 0.05 | 0.17 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.03 | 0.16 | 0.22 | 0.10 | 0.06 | 0.10 | 0.05 | 0.14 | 0.21 | 0.09 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 |
| ADAMTS12 | ENSG00000151388 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.02 | 0.11 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.18 | 0.00 | 0.20 | 0.01 | 0.07 | 0.00 | 0.11 | 0.01 | 0.11 | 0.03 | 0.05 | 0.01 | 0.04 | 0.00 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.30 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.07 | 0.02 | 0.23 | 0.02 | 0.08 | 0.00 | 0.07 | 0.01 | 0.16 | 0.05 | 0.19 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.05 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.12 | 0.03 |
| SLC6A13 | ENSG00000010379 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.02 | 0.01 | 0.06 | 0.12 | 0.04 | 0.01 | 0.00 | 0.04 | 0.01 | 0.11 | 0.07 | 0.23 | 0.02 | 0.19 | 0.01 | 0.26 | 0.04 | 0.11 | 0.06 | 0.14 | 0.01 | 0.15 | 0.03 | 0.14 | 0.04 | 0.04 | 0.05 | 0.30 | 0.08 | 0.06 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.19 | 0.05 | 0.47 | 0.10 | 0.05 | 0.03 | 0.11 | 0.04 | 0.32 | 0.10 | 0.22 | 0.14 | 0.57 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.12 | 0.03 | 0.05 | 0.02 | 0.00 | 0.03 | 0.08 | 0.03 |
| NRXN2 | ENSG00000110076 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.03 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.05 | 0.03 | 0.07 | 0.02 | 0.18 | 0.02 | 0.12 | 0.05 | 0.04 | 0.03 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.07 | 0.08 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 0.08 | 0.17 | 0.05 | 0.12 | 0.01 | 0.08 | 0.03 | 0.22 | 0.04 | 0.08 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.05 |
| PTPRA | ENSG00000132670 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.02 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.04 | 0.15 | 0.01 | 0.03 | 0.03 | 0.07 | 0.04 | 0.05 | 0.02 | 0.06 | 0.04 | 0.06 | 0.09 | 0.01 | 0.03 | 0.04 | 0.01 | 0.00 | 0.03 | 0.00 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.06 | 0.34 | 0.08 | 0.04 | 0.02 | 0.09 | 0.03 | 0.13 | 0.07 | 0.07 | 0.09 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.03 |
| LMAN1 | ENSG00000074695 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.09 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.11 | 0.04 | 0.07 | 0.01 | 0.14 | 0.03 | 0.22 | 0.01 | 0.17 | 0.00 | 0.11 | 0.00 | 0.10 | 0.00 | 0.08 | 0.02 | 0.07 | 0.00 | 0.10 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.05 | 0.05 | 0.32 | 0.00 | 0.04 | 0.01 | 0.07 | 0.07 | 0.11 | 0.10 | 0.06 | 0.00 | 0.07 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.03 | 0.01 | 0.03 | 0.00 | 0.01 | 0.02 | 0.02 |
| ABCC4 | ENSG00000125257 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.09 | 0.15 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.11 | 0.04 | 0.13 | 0.05 | 0.08 | 0.03 | 0.09 | 0.05 | 0.13 | 0.03 | 0.10 | 0.01 | 0.13 | 0.01 | 0.01 | 0.02 | 0.23 | 0.03 | 0.06 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.04 | 0.25 | 0.09 | 0.16 | 0.03 | 0.05 | 0.02 | 0.58 | 0.05 | 0.21 | 0.13 | 0.01 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 | 0.02 | 0.02 | 0.03 | 0.05 | 0.05 | 0.00 | 0.08 | 0.05 |
| SLC26A6 | ENSG00000225697 | 0.00 | 0.18 | 0.00 | 0.02 | 0.05 | 0.00 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.03 | 0.00 | 0.55 | 0.01 | 0.06 | 0.00 | 0.10 | 0.00 | 0.06 | 0.03 | 0.12 | 0.01 | 0.11 | 0.00 | 0.05 | 0.02 | 0.10 | 0.00 | 0.04 | 0.03 | 0.05 | 0.00 | 0.24 | 0.01 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.16 | 0.10 | 0.20 | 0.01 | 0.06 | 0.06 | 0.05 | 0.15 | 0.32 | 0.03 | 0.13 | 0.02 | 0.04 | 0.00 | 0.01 | 0.00 | 0.11 | 0.01 | 0.06 | 0.01 | 0.04 | 0.00 | 0.03 | 0.02 | 0.05 |
| MFSD4 | ENSG00000174514 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.06 | 0.05 | 0.01 | 0.00 | 0.12 | 0.00 | 0.13 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.17 | 0.07 | 0.06 | 0.02 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.20 | 0.01 | 0.18 | 0.02 | 0.03 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.29 | 0.08 | 0.07 | 0.00 | 0.15 | 0.01 | 0.27 | 0.00 | 0.06 | 0.17 | 0.05 | 0.02 | 0.01 | 0.00 | 0.21 | 0.04 | 0.00 | 0.01 | 0.08 | 0.02 | 0.09 | 0.00 | 0.18 | 0.02 |
| PMPCA | ENSG00000165688 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.04 | 0.07 | 0.02 | 0.07 | 0.05 | 0.17 | 0.01 | 0.14 | 0.02 | 0.03 | 0.01 | 0.08 | 0.05 | 0.01 | 0.00 | 0.07 | 0.04 | 0.06 | 0.01 | 0.17 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.06 | 0.17 | 0.22 | 0.06 | 0.02 | 0.05 | 0.04 | 0.04 | 0.14 | 0.07 | 0.15 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| PXDN | ENSG00000130508 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.01 | 0.15 | 0.03 | 0.00 | 0.00 | 0.03 | 0.04 | 0.07 | 0.03 | 0.12 | 0.07 | 0.03 | 0.04 | 0.05 | 0.07 | 0.03 | 0.04 | 0.02 | 0.02 | 0.04 | 0.04 | 0.01 | 0.04 | 0.11 | 0.01 | 0.00 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.04 | 0.29 | 0.18 | 0.09 | 0.02 | 0.11 | 0.04 | 0.30 | 0.08 | 0.04 | 0.19 | 0.14 | 0.02 | 0.00 | 0.00 | 0.02 | 0.08 | 0.03 | 0.03 | 0.02 | 0.05 | 0.05 | 0.00 | 0.02 | 0.04 |
| ADAMTS3 | ENSG00000156140 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.18 | 0.02 | 0.00 | 0.00 | 0.00 | 0.07 | 0.07 | 0.02 | 0.22 | 0.01 | 0.10 | 0.01 | 0.21 | 0.02 | 0.07 | 0.01 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.01 | 0.01 | 0.09 | 0.00 | 0.03 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.15 | 0.02 | 0.36 | 0.09 | 0.05 | 0.03 | 0.04 | 0.02 | 0.12 | 0.05 | 0.08 | 0.05 | 0.11 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 |
| EPHX2 | ENSG00000120915 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.19 | 0.01 | 0.10 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.06 | 0.01 | 0.09 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.18 | 0.00 | 0.04 | 0.03 | 0.10 | 0.00 | 0.08 | 0.05 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.04 | 0.14 | 0.05 | 0.40 | 0.00 | 0.03 | 0.01 | 0.10 | 0.09 | 0.14 | 0.08 | 0.07 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.05 |
| PTPN22 | ENSG00000134242 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.31 | 0.01 | 0.14 | 0.02 | 0.16 | 0.00 | 0.15 | 0.05 | 0.19 | 0.07 | 0.08 | 0.00 | 0.07 | 0.06 | 0.08 | 0.01 | 0.02 | 0.03 | 0.03 | 0.00 | 0.11 | 0.02 | 0.05 | 0.00 | 0.26 | 0.00 | 0.00 | 0.04 | 0.09 | 0.17 | 0.14 | 0.04 | 0.08 | 0.02 | 0.03 | 0.06 | 0.06 | 0.04 | 0.12 | 0.05 | 0.04 | 0.00 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.05 | 0.12 | 0.10 |
| TEC | ENSG00000135605 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.17 | 0.03 | 0.05 | 0.02 | 0.10 | 0.04 | 0.03 | 0.04 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.02 | 0.04 | 0.03 | 0.00 | 0.14 | 0.04 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.05 | 0.01 | 0.13 | 0.03 | 0.01 | 0.02 | 0.03 | 0.01 | 0.06 | 0.00 | 0.11 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.05 | 0.04 | 0.02 | 0.02 |
| LRRK2 | ENSG00000188906 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.07 | 0.03 | 0.00 | 0.00 | 0.01 | 0.05 | 0.10 | 0.03 | 0.05 | 0.02 | 0.03 | 0.03 | 0.04 | 0.07 | 0.07 | 0.05 | 0.01 | 0.01 | 0.02 | 0.02 | 0.06 | 0.04 | 0.02 | 0.02 | 0.00 | 0.01 | 0.11 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 | 0.19 | 0.04 | 0.05 | 0.00 | 0.05 | 0.00 | 0.14 | 0.05 | 0.21 | 0.10 | 0.09 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.03 | 0.06 | 0.02 | 0.05 | 0.00 | 0.00 | 0.05 | 0.05 |
| TMIGD2 | ENSG00000167664 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.04 | 0.01 | 0.03 | 0.03 | 0.12 | 0.02 | 0.01 | 0.01 | 0.10 | 0.01 | 0.08 | 0.03 | 0.12 | 0.02 | 0.11 | 0.07 | 0.11 | 0.01 | 0.10 | 0.00 | 0.04 | 0.02 | 0.09 | 0.00 | 0.06 | 0.06 | 0.13 | 0.00 | 0.03 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.11 | 0.03 | 0.81 | 0.03 | 0.19 | 0.00 | 0.27 | 0.00 | 0.74 | 0.16 | 0.07 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.03 | 0.01 | 0.01 | 0.06 | 0.01 | 0.00 | 0.05 | 0.04 | 0.04 |
| PENK | ENSG00000181195 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.00 | 0.04 | 0.01 | 0.09 | 0.02 | 0.00 | 0.00 | 0.00 | 0.07 | 0.12 | 0.03 | 0.12 | 0.03 | 0.04 | 0.01 | 0.07 | 0.03 | 0.07 | 0.02 | 0.07 | 0.01 | 0.10 | 0.01 | 0.01 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.16 | 0.02 | 0.42 | 0.03 | 0.03 | 0.01 | 0.12 | 0.00 | 0.73 | 0.09 | 0.16 | 0.04 | 0.21 | 0.00 | 0.01 | 0.00 | 0.04 | 0.09 | 0.00 | 0.00 | 0.00 | 0.01 | 0.20 | 0.00 | 0.06 | 0.01 |
| ABCB7 | ENSG00000131269 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.06 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.05 | 0.04 | 0.02 | 0.01 | 0.05 | 0.03 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.26 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.11 | 0.03 | 0.06 | 0.02 | 0.03 | 0.01 | 0.04 | 0.00 | 0.13 | 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 |
|
Showing page 192 |
first page | previous page | next page | last page |