Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SLC22A15 | ENSG00000163393 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.04 | 0.10 | 0.05 | 0.00 | 0.00 | 0.00 | 0.28 | 0.02 | 0.14 | 0.02 | 0.18 | 0.00 | 0.16 | 0.18 | 0.15 | 0.02 | 0.08 | 0.00 | 0.06 | 0.01 | 0.07 | 0.13 | 0.02 | 0.01 | 0.03 | 0.00 | 0.10 | 0.05 | 0.05 | 0.03 | 0.26 | 0.00 | 0.00 | 0.05 | 0.08 | 0.18 | 0.13 | 0.02 | 0.08 | 0.03 | 0.03 | 0.03 | 0.06 | 0.04 | 0.11 | 0.05 | 0.03 | 0.00 | 0.01 | 0.03 | 0.17 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.05 | 0.10 | 0.09 |
| HDAC4 | ENSG00000068024 | 0.01 | 0.08 | 0.04 | 0.05 | 0.00 | 0.05 | 0.01 | 0.05 | 0.00 | 0.31 | 0.00 | 0.01 | 0.00 | 0.06 | 0.06 | 0.05 | 0.03 | 0.19 | 0.01 | 0.18 | 0.05 | 0.16 | 0.03 | 0.10 | 0.02 | 0.03 | 0.03 | 0.04 | 0.04 | 0.04 | 0.03 | 0.09 | 0.05 | 0.01 | 0.06 | 0.12 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.11 | 0.19 | 0.29 | 0.02 | 0.38 | 0.04 | 0.06 | 0.13 | 0.09 | 0.08 | 0.46 | 0.03 | 0.06 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.14 | 0.00 | 0.03 | 0.01 | 0.08 | 0.02 | 0.17 |
| CD46 | ENSG00000117335 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.06 | 0.01 | 0.00 | 0.07 | 0.01 | 0.12 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.15 | 0.06 | 0.06 | 0.02 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.16 | 0.01 | 0.18 | 0.02 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.27 | 0.01 | 0.20 | 0.12 | 0.06 | 0.00 | 0.06 | 0.02 | 0.13 | 0.04 | 0.06 | 0.18 | 0.02 | 0.03 | 0.01 | 0.00 | 0.16 | 0.10 | 0.00 | 0.02 | 0.03 | 0.02 | 0.09 | 0.00 | 0.14 | 0.02 |
| NTNG1 | ENSG00000162631 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.05 | 0.06 | 0.00 | 0.00 | 0.00 | 0.34 | 0.02 | 0.14 | 0.03 | 0.12 | 0.01 | 0.11 | 0.03 | 0.11 | 0.03 | 0.06 | 0.00 | 0.07 | 0.01 | 0.06 | 0.00 | 0.02 | 0.03 | 0.03 | 0.00 | 0.11 | 0.04 | 0.04 | 0.00 | 0.25 | 0.00 | 0.00 | 0.05 | 0.11 | 0.13 | 0.15 | 0.06 | 0.07 | 0.03 | 0.03 | 0.01 | 0.06 | 0.07 | 0.10 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.07 | 0.10 |
| ADGRV1 | ENSG00000164199 | 0.02 | 0.01 | 0.01 | 0.01 | 0.06 | 0.01 | 0.01 | 0.15 | 0.01 | 0.09 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.08 | 0.00 | 0.09 | 0.00 | 0.07 | 0.01 | 0.12 | 0.00 | 0.12 | 0.01 | 0.11 | 0.01 | 0.04 | 0.01 | 0.06 | 0.08 | 0.04 | 0.00 | 0.08 | 0.08 | 0.05 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.08 | 0.07 | 0.59 | 0.01 | 0.05 | 0.00 | 0.08 | 0.06 | 0.23 | 0.03 | 0.05 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.04 |
| HDAC2 | ENSG00000196591 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.28 | 0.01 | 0.12 | 0.00 | 0.01 | 0.00 | 0.16 | 0.01 | 0.05 | 0.03 | 0.05 | 0.02 | 0.03 | 0.06 | 0.07 | 0.03 | 0.06 | 0.01 | 0.03 | 0.01 | 0.06 | 0.00 | 0.04 | 0.01 | 0.07 | 0.00 | 0.12 | 0.02 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.09 | 0.06 | 0.28 | 0.01 | 0.02 | 0.04 | 0.02 | 0.05 | 0.03 | 0.15 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.18 | 0.00 | 0.04 | 0.00 | 0.08 | 0.00 | 0.03 | 0.00 | 0.14 |
| ACAN | ENSG00000157766 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.02 | 0.02 | 0.04 | 0.02 | 0.03 | 0.00 | 0.06 | 0.00 | 0.05 | 0.01 | 0.19 | 0.00 | 0.05 | 0.02 | 0.16 | 0.02 | 0.23 | 0.01 | 0.04 | 0.01 | 0.10 | 0.00 | 0.06 | 0.01 | 0.06 | 0.04 | 0.05 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.16 | 0.03 | 0.29 | 0.08 | 0.18 | 0.00 | 0.04 | 0.03 | 0.22 | 0.05 | 0.13 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.19 | 0.01 |
| CSNK1A1 | ENSG00000113712 | 0.30 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 | 0.03 | 0.05 | 0.00 | 0.00 | 0.02 | 0.05 | 0.05 | 0.05 | 0.01 | 0.04 | 0.01 | 0.04 | 0.06 | 0.03 | 0.04 | 0.05 | 0.01 | 0.02 | 0.03 | 0.01 | 0.03 | 0.02 | 0.10 | 0.02 | 0.09 | 0.01 | 0.24 | 0.04 | 0.00 | 0.03 | 0.01 | 0.00 | 0.04 | 0.02 | 0.20 | 0.09 | 0.03 | 0.02 | 0.04 | 0.02 | 0.12 | 0.02 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 | 0.03 | 0.00 | 0.03 | 0.05 | 0.14 |
| ITGA3 | ENSG00000005884 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.13 | 0.01 | 0.00 | 0.00 | 0.09 | 0.00 | 0.09 | 0.00 | 0.11 | 0.01 | 0.02 | 0.01 | 0.16 | 0.01 | 0.10 | 0.01 | 0.03 | 0.01 | 0.06 | 0.04 | 0.06 | 0.02 | 0.05 | 0.01 | 0.02 | 0.01 | 0.05 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.50 | 0.03 | 0.19 | 0.04 | 0.07 | 0.00 | 0.08 | 0.03 | 0.34 | 0.02 | 0.11 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.03 | 0.03 | 0.12 | 0.01 |
| SLC6A19 | ENSG00000174358 | 0.01 | 0.01 | 0.03 | 0.01 | 0.07 | 0.11 | 0.03 | 0.01 | 0.28 | 0.02 | 0.00 | 0.01 | 0.06 | 0.00 | 0.41 | 0.01 | 0.38 | 0.01 | 0.16 | 0.01 | 0.33 | 0.03 | 0.18 | 0.02 | 0.04 | 0.02 | 0.06 | 0.02 | 0.03 | 0.01 | 0.27 | 0.02 | 0.00 | 0.05 | 0.77 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.13 | 0.02 | 0.48 | 0.05 | 0.21 | 0.02 | 0.16 | 0.01 | 0.26 | 0.03 | 0.42 | 0.13 | 0.03 | 0.03 | 0.00 | 0.00 | 0.17 | 0.00 | 0.03 | 0.06 | 0.06 | 0.04 | 0.03 | 0.02 | 0.35 | 0.07 |
| BPTF | ENSG00000171634 | 0.02 | 0.00 | 0.04 | 0.00 | 0.02 | 0.00 | 0.03 | 0.02 | 0.20 | 0.01 | 0.02 | 0.00 | 0.12 | 0.00 | 0.16 | 0.00 | 0.21 | 0.00 | 0.07 | 0.02 | 0.22 | 0.03 | 0.10 | 0.03 | 0.12 | 0.01 | 0.09 | 0.01 | 0.07 | 0.10 | 0.21 | 0.01 | 0.12 | 0.01 | 0.17 | 0.06 | 0.02 | 0.01 | 0.00 | 0.00 | 0.57 | 0.01 | 0.25 | 0.03 | 0.15 | 0.02 | 0.15 | 0.01 | 0.49 | 0.02 | 0.21 | 0.04 | 0.04 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.06 | 0.00 | 0.03 | 0.01 | 0.17 | 0.01 | 0.24 | 0.01 |
| CDC14A | ENSG00000079335 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.07 | 0.03 | 0.06 | 0.00 | 0.00 | 0.00 | 0.39 | 0.03 | 0.12 | 0.02 | 0.10 | 0.01 | 0.08 | 0.02 | 0.10 | 0.02 | 0.06 | 0.00 | 0.07 | 0.01 | 0.06 | 0.00 | 0.02 | 0.04 | 0.04 | 0.00 | 0.11 | 0.04 | 0.04 | 0.00 | 0.25 | 0.00 | 0.00 | 0.02 | 0.11 | 0.15 | 0.18 | 0.00 | 0.07 | 0.03 | 0.02 | 0.01 | 0.06 | 0.06 | 0.09 | 0.03 | 0.05 | 0.00 | 0.00 | 0.00 | 0.07 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.03 | 0.05 | 0.10 |
| BIRC2 | ENSG00000110330 | 0.02 | 0.00 | 0.00 | 0.05 | 0.03 | 0.03 | 0.02 | 0.05 | 0.26 | 0.06 | 0.00 | 0.00 | 0.06 | 0.06 | 0.11 | 0.04 | 0.12 | 0.07 | 0.44 | 0.09 | 0.14 | 0.08 | 0.07 | 0.05 | 0.04 | 0.01 | 0.02 | 0.02 | 0.02 | 0.01 | 0.04 | 0.06 | 0.00 | 0.10 | 0.01 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.06 | 0.18 | 0.35 | 0.12 | 0.86 | 0.09 | 0.05 | 0.04 | 0.07 | 0.17 | 0.30 | 0.11 | 0.02 | 0.07 | 0.02 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.17 | 0.12 |
| CHST12 | ENSG00000136213 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.14 | 0.03 | 0.00 | 0.00 | 0.10 | 0.00 | 0.11 | 0.02 | 0.15 | 0.04 | 0.13 | 0.01 | 0.24 | 0.03 | 0.17 | 0.02 | 0.05 | 0.00 | 0.05 | 0.01 | 0.05 | 0.00 | 0.07 | 0.02 | 0.01 | 0.01 | 0.11 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.06 | 0.13 | 0.40 | 0.04 | 0.02 | 0.06 | 0.07 | 0.10 | 0.05 | 0.14 | 0.03 | 0.16 | 0.02 | 0.00 | 0.01 | 0.13 | 0.00 | 0.01 | 0.04 | 0.06 | 0.01 | 0.00 | 0.00 | 0.16 | 0.02 |
| IL1R1 | ENSG00000115594 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.10 | 0.01 | 0.08 | 0.01 | 0.15 | 0.02 | 0.07 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.01 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.20 | 0.07 | 0.04 | 0.01 | 0.05 | 0.02 | 0.18 | 0.00 | 0.13 | 0.04 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 |
| UBA2 | ENSG00000126261 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.21 | 0.02 | 0.00 | 0.00 | 0.07 | 0.02 | 0.25 | 0.01 | 0.37 | 0.02 | 0.05 | 0.02 | 0.19 | 0.05 | 0.12 | 0.05 | 0.05 | 0.01 | 0.03 | 0.00 | 0.10 | 0.00 | 0.05 | 0.02 | 0.13 | 0.03 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.12 | 0.02 | 0.68 | 0.04 | 0.11 | 0.02 | 0.17 | 0.02 | 1.39 | 0.00 | 0.22 | 0.04 | 0.02 | 0.02 | 0.00 | 0.01 | 0.08 | 0.00 | 0.02 | 0.01 | 0.03 | 0.02 | 0.00 | 0.00 | 0.06 | 0.01 |
| NOTCH1 | ENSG00000148400 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.07 | 0.04 | 0.08 | 0.04 | 0.08 | 0.07 | 0.20 | 0.01 | 0.16 | 0.02 | 0.04 | 0.01 | 0.10 | 0.05 | 0.01 | 0.00 | 0.06 | 0.04 | 0.06 | 0.01 | 0.18 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.07 | 0.06 | 0.17 | 0.23 | 0.06 | 0.02 | 0.08 | 0.04 | 0.18 | 0.09 | 0.08 | 0.17 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.04 | 0.03 |
| THBS1 | ENSG00000137801 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.06 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.37 | 0.01 | 0.11 | 0.01 | 0.10 | 0.02 | 0.04 | 0.03 | 0.05 | 0.01 | 0.08 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.04 | 0.00 | 0.03 | 0.00 | 0.07 | 0.02 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.12 | 0.04 | 0.36 | 0.00 | 0.09 | 0.01 | 0.10 | 0.05 | 0.51 | 0.03 | 0.10 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.10 | 0.00 | 0.03 | 0.01 | 0.12 | 0.00 | 0.00 | 0.02 | 0.18 |
| PTPRR | ENSG00000153233 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.30 | 0.03 | 0.00 | 0.00 | 0.03 | 0.00 | 0.22 | 0.01 | 0.24 | 0.01 | 0.21 | 0.02 | 0.35 | 0.01 | 0.27 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.11 | 0.02 | 0.02 | 0.00 | 0.06 | 0.01 | 0.30 | 0.02 | 0.05 | 0.02 | 0.00 | 0.00 | 0.26 | 0.02 | 0.28 | 0.05 | 0.07 | 0.01 | 0.04 | 0.01 | 0.59 | 0.07 | 1.11 | 0.04 | 0.28 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.02 | 0.02 | 0.16 | 0.03 | 0.02 | 0.00 | 0.24 | 0.02 |
| RANBP2 | ENSG00000153201 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.09 | 0.02 | 0.07 | 0.01 | 0.15 | 0.01 | 0.07 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.09 | 0.11 | 0.04 | 0.02 | 0.04 | 0.01 | 0.06 | 0.00 | 0.15 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.09 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 |
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