Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 180 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| ATP6V1C1 | ENSG00000155097 | 0.01 | 0.01 | 0.01 | 0.00 | 0.21 | 0.00 | 0.08 | 0.01 | 0.54 | 0.01 | 0.02 | 0.00 | 0.02 | 0.01 | 0.20 | 0.01 | 0.24 | 0.01 | 0.18 | 0.00 | 0.36 | 0.00 | 0.26 | 0.00 | 0.13 | 0.01 | 0.20 | 0.00 | 0.05 | 0.01 | 0.31 | 0.00 | 0.25 | 0.01 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.48 | 0.01 | 0.72 | 0.07 | 0.13 | 0.00 | 0.11 | 0.01 | 0.49 | 0.00 | 0.15 | 0.06 | 0.08 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.14 | 0.00 | 0.01 | 0.01 | 0.42 | 0.00 | 0.14 | 0.01 |
| ATP1A1 | ENSG00000163399 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.04 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.14 | 0.03 | 0.19 | 0.00 | 0.16 | 0.18 | 0.15 | 0.03 | 0.09 | 0.00 | 0.06 | 0.01 | 0.07 | 0.13 | 0.02 | 0.02 | 0.04 | 0.00 | 0.10 | 0.05 | 0.05 | 0.04 | 0.25 | 0.00 | 0.00 | 0.05 | 0.08 | 0.18 | 0.12 | 0.01 | 0.08 | 0.03 | 0.03 | 0.08 | 0.06 | 0.04 | 0.11 | 0.04 | 0.03 | 0.00 | 0.01 | 0.03 | 0.17 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.05 | 0.10 | 0.09 |
| DLK1 | ENSG00000185559 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.04 | 0.02 | 0.03 | 0.08 | 0.06 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.06 | 0.18 | 0.03 | 0.06 | 0.05 | 0.07 | 0.03 | 0.03 | 0.06 | 0.00 | 0.03 | 0.02 | 0.04 | 0.01 | 0.02 | 0.01 | 0.10 | 0.00 | 0.31 | 0.18 | 0.03 | 0.04 | 0.03 | 0.00 | 0.00 | 0.06 | 0.08 | 0.21 | 0.16 | 0.06 | 0.10 | 0.05 | 0.02 | 0.06 | 0.02 | 0.13 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.08 | 0.02 | 0.06 | 0.03 | 0.01 | 0.01 | 0.06 |
| RXRG | ENSG00000143171 | 0.03 | 0.00 | 0.02 | 0.01 | 0.00 | 0.03 | 0.01 | 0.06 | 0.59 | 0.01 | 0.02 | 0.00 | 0.10 | 0.02 | 0.19 | 0.00 | 0.26 | 0.01 | 0.05 | 0.01 | 0.21 | 0.00 | 0.13 | 0.00 | 0.03 | 0.00 | 0.08 | 0.00 | 0.06 | 0.00 | 0.26 | 0.00 | 0.30 | 0.01 | 0.05 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.23 | 0.01 | 0.35 | 0.02 | 0.17 | 0.00 | 0.13 | 0.00 | 0.31 | 0.00 | 0.32 | 0.03 | 0.09 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.14 | 0.01 |
| P2RY6 | ENSG00000171631 | 0.00 | 0.00 | 0.01 | 0.00 | 0.10 | 0.00 | 0.04 | 0.00 | 0.20 | 0.03 | 0.00 | 0.00 | 0.08 | 0.00 | 0.14 | 0.01 | 0.22 | 0.02 | 0.33 | 0.02 | 0.60 | 0.03 | 0.14 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 0.05 | 0.02 | 0.08 | 0.02 | 0.04 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.38 | 0.06 | 0.53 | 0.04 | 0.12 | 0.01 | 0.11 | 0.02 | 0.32 | 0.08 | 0.16 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.27 | 0.01 |
| OR51E2 | ENSG00000167332 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.10 | 0.00 | 0.00 | 0.03 | 0.05 | 0.02 | 0.06 | 0.02 | 0.14 | 0.01 | 0.07 | 0.02 | 0.10 | 0.03 | 0.05 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.04 | 0.03 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.00 | 0.02 | 0.11 | 0.02 | 0.44 | 0.01 | 0.05 | 0.03 | 0.06 | 0.03 | 0.09 | 0.04 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.03 |
| TNFRSF10A | ENSG00000104689 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.24 | 0.01 | 0.15 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.08 | 0.00 | 0.11 | 0.00 | 0.07 | 0.02 | 0.06 | 0.03 | 0.04 | 0.00 | 0.12 | 0.01 | 0.18 | 0.00 | 0.05 | 0.00 | 0.12 | 0.00 | 0.05 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.17 | 0.01 | 0.45 | 0.00 | 0.05 | 0.01 | 0.11 | 0.00 | 0.24 | 0.01 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.04 |
| ALB | ENSG00000163631 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.18 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.08 | 0.02 | 0.24 | 0.01 | 0.10 | 0.01 | 0.22 | 0.02 | 0.08 | 0.01 | 0.02 | 0.01 | 0.05 | 0.01 | 0.00 | 0.01 | 0.06 | 0.10 | 0.00 | 0.03 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.17 | 0.02 | 0.33 | 0.10 | 0.07 | 0.03 | 0.04 | 0.02 | 0.15 | 0.05 | 0.07 | 0.05 | 0.11 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 |
| RGS4 | ENSG00000117152 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.04 | 0.69 | 0.01 | 0.02 | 0.00 | 0.11 | 0.02 | 0.22 | 0.00 | 0.26 | 0.01 | 0.05 | 0.00 | 0.21 | 0.01 | 0.12 | 0.00 | 0.03 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.29 | 0.00 | 0.30 | 0.01 | 0.12 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.26 | 0.01 | 0.37 | 0.02 | 0.15 | 0.00 | 0.13 | 0.00 | 0.28 | 0.00 | 0.33 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 |
| ATP6V1H | ENSG00000047249 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.05 | 0.02 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.07 | 0.11 | 0.02 | 0.13 | 0.03 | 0.08 | 0.01 | 0.08 | 0.03 | 0.07 | 0.02 | 0.05 | 0.02 | 0.10 | 0.01 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.15 | 0.02 | 0.44 | 0.02 | 0.02 | 0.01 | 0.11 | 0.01 | 0.92 | 0.09 | 0.11 | 0.04 | 0.23 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.01 | 0.20 | 0.00 | 0.06 | 0.01 |
| KCNJ10 | ENSG00000177807 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.04 | 0.75 | 0.00 | 0.02 | 0.00 | 0.10 | 0.02 | 0.28 | 0.00 | 0.27 | 0.00 | 0.06 | 0.00 | 0.27 | 0.00 | 0.13 | 0.00 | 0.04 | 0.00 | 0.11 | 0.00 | 0.06 | 0.00 | 0.28 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.42 | 0.02 | 0.16 | 0.00 | 0.15 | 0.00 | 0.28 | 0.00 | 0.52 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.16 | 0.00 |
| CEACAM6 | ENSG00000086548 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.03 | 0.14 | 0.03 | 0.00 | 0.00 | 0.05 | 0.05 | 0.10 | 0.04 | 0.16 | 0.07 | 0.01 | 0.02 | 0.06 | 0.06 | 0.08 | 0.03 | 0.03 | 0.01 | 0.03 | 0.02 | 0.02 | 0.04 | 0.02 | 0.03 | 0.12 | 0.01 | 0.06 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.05 | 0.16 | 0.27 | 0.11 | 0.04 | 0.05 | 0.04 | 0.09 | 0.17 | 0.25 | 0.10 | 0.00 | 0.04 | 0.01 | 0.00 | 0.05 | 0.03 | 0.02 | 0.09 | 0.02 | 0.09 | 0.00 | 0.00 | 0.03 | 0.03 |
| ITGB6 | ENSG00000115221 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.12 | 0.05 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.10 | 0.03 | 0.05 | 0.02 | 0.14 | 0.03 | 0.03 | 0.05 | 0.01 | 0.02 | 0.01 | 0.02 | 0.05 | 0.01 | 0.05 | 0.06 | 0.00 | 0.05 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.33 | 0.04 | 0.05 | 0.01 | 0.08 | 0.01 | 0.06 | 0.00 | 0.08 | 0.11 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.15 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.04 | 0.01 |
| POSTN | ENSG00000133110 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.28 | 0.09 | 0.17 | 0.00 | 0.02 | 0.00 | 0.18 | 0.02 | 0.08 | 0.03 | 0.10 | 0.02 | 0.16 | 0.07 | 0.07 | 0.14 | 0.03 | 0.13 | 0.02 | 0.17 | 0.02 | 0.01 | 0.01 | 0.01 | 0.20 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.12 | 0.05 | 0.21 | 0.01 | 0.21 | 0.00 | 0.05 | 0.07 | 0.23 | 0.09 | 0.26 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.06 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.03 |
| GLRX3 | ENSG00000108010 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.09 | 0.00 | 0.05 | 0.02 | 0.15 | 0.03 | 0.05 | 0.05 | 0.07 | 0.02 | 0.04 | 0.04 | 0.08 | 0.07 | 0.07 | 0.01 | 0.05 | 0.02 | 0.04 | 0.01 | 0.02 | 0.02 | 0.11 | 0.14 | 0.17 | 0.11 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.06 | 0.11 | 0.25 | 0.21 | 0.02 | 0.05 | 0.05 | 0.06 | 0.08 | 0.04 | 0.09 | 0.09 | 0.05 | 0.05 | 0.00 | 0.00 | 0.03 | 0.03 | 0.01 | 0.13 | 0.00 | 0.07 | 0.00 | 0.00 | 0.01 | 0.05 |
| JAK3 | ENSG00000105639 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.05 | 0.01 | 0.02 | 0.02 | 0.10 | 0.03 | 0.05 | 0.02 | 0.12 | 0.01 | 0.03 | 0.02 | 0.02 | 0.00 | 0.01 | 0.04 | 0.01 | 0.02 | 0.08 | 0.03 | 0.06 | 0.03 | 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.58 | 0.04 | 0.02 | 0.01 | 0.22 | 0.02 | 0.25 | 0.07 | 0.08 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.04 | 0.01 |
| DUSP10 | ENSG00000143507 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.10 | 0.05 | 0.02 | 0.00 | 0.05 | 0.01 | 0.09 | 0.01 | 0.11 | 0.01 | 0.05 | 0.00 | 0.20 | 0.03 | 0.08 | 0.01 | 0.02 | 0.01 | 0.07 | 0.03 | 0.01 | 0.01 | 0.16 | 0.03 | 0.16 | 0.02 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.23 | 0.02 | 0.29 | 0.10 | 0.06 | 0.01 | 0.08 | 0.03 | 0.16 | 0.00 | 0.04 | 0.21 | 0.02 | 0.03 | 0.01 | 0.00 | 0.03 | 0.12 | 0.00 | 0.03 | 0.02 | 0.07 | 0.09 | 0.00 | 0.11 | 0.04 |
| PDGFRB | ENSG00000113721 | 0.31 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 | 0.03 | 0.05 | 0.00 | 0.00 | 0.02 | 0.05 | 0.04 | 0.04 | 0.01 | 0.03 | 0.01 | 0.04 | 0.04 | 0.02 | 0.03 | 0.04 | 0.02 | 0.01 | 0.04 | 0.01 | 0.02 | 0.02 | 0.10 | 0.02 | 0.09 | 0.01 | 0.26 | 0.04 | 0.00 | 0.03 | 0.01 | 0.00 | 0.04 | 0.02 | 0.17 | 0.09 | 0.03 | 0.01 | 0.04 | 0.02 | 0.19 | 0.02 | 0.08 | 0.06 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 | 0.03 | 0.00 | 0.03 | 0.04 | 0.14 |
| SERPINA1 | ENSG00000197249 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.04 | 0.07 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.06 | 0.12 | 0.02 | 0.05 | 0.04 | 0.07 | 0.06 | 0.03 | 0.05 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.02 | 0.03 | 0.10 | 0.00 | 0.31 | 0.05 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.09 | 0.20 | 0.17 | 0.07 | 0.09 | 0.04 | 0.03 | 0.06 | 0.02 | 0.06 | 0.08 | 0.03 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.10 | 0.01 | 0.06 | 0.03 | 0.01 | 0.01 | 0.06 |
| RORC | ENSG00000143365 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.58 | 0.01 | 0.02 | 0.00 | 0.11 | 0.02 | 0.41 | 0.00 | 0.30 | 0.00 | 0.06 | 0.01 | 0.31 | 0.00 | 0.23 | 0.00 | 0.02 | 0.00 | 0.17 | 0.00 | 0.07 | 0.00 | 0.35 | 0.00 | 0.43 | 0.01 | 0.20 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.35 | 0.00 | 0.64 | 0.02 | 0.22 | 0.00 | 0.30 | 0.00 | 0.68 | 0.00 | 0.46 | 0.03 | 0.12 | 0.01 | 0.00 | 0.00 | 0.24 | 0.04 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 |
|
Showing page 180 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.