Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| RRM1 | ENSG00000167325 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.05 | 0.02 | 0.06 | 0.02 | 0.15 | 0.01 | 0.07 | 0.04 | 0.09 | 0.02 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.04 | 0.03 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.00 | 0.03 | 0.10 | 0.02 | 0.43 | 0.01 | 0.05 | 0.02 | 0.06 | 0.03 | 0.09 | 0.06 | 0.14 | 0.02 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| PSMD14 | ENSG00000115233 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.13 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.08 | 0.03 | 0.04 | 0.02 | 0.10 | 0.03 | 0.03 | 0.04 | 0.01 | 0.02 | 0.01 | 0.02 | 0.05 | 0.01 | 0.04 | 0.06 | 0.00 | 0.05 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.31 | 0.04 | 0.04 | 0.01 | 0.06 | 0.01 | 0.03 | 0.02 | 0.05 | 0.09 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.15 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
| SERPINE2 | ENSG00000135919 | 0.01 | 0.07 | 0.04 | 0.04 | 0.00 | 0.05 | 0.01 | 0.02 | 0.01 | 0.29 | 0.00 | 0.02 | 0.00 | 0.10 | 0.03 | 0.04 | 0.01 | 0.20 | 0.01 | 0.19 | 0.04 | 0.14 | 0.06 | 0.04 | 0.02 | 0.02 | 0.02 | 0.02 | 0.07 | 0.03 | 0.03 | 0.05 | 0.00 | 0.04 | 0.03 | 0.02 | 0.02 | 0.01 | 0.00 | 0.01 | 0.03 | 0.07 | 0.16 | 0.19 | 0.01 | 0.36 | 0.04 | 0.05 | 0.13 | 0.05 | 0.07 | 0.20 | 0.06 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.03 | 0.06 |
| PDGFA | ENSG00000197461 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.14 | 0.04 | 0.00 | 0.00 | 0.10 | 0.00 | 0.11 | 0.01 | 0.16 | 0.04 | 0.13 | 0.02 | 0.26 | 0.03 | 0.16 | 0.02 | 0.05 | 0.00 | 0.04 | 0.00 | 0.06 | 0.00 | 0.06 | 0.02 | 0.01 | 0.01 | 0.16 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.14 | 0.41 | 0.05 | 0.02 | 0.05 | 0.08 | 0.18 | 0.05 | 0.16 | 0.06 | 0.15 | 0.01 | 0.00 | 0.01 | 0.12 | 0.00 | 0.01 | 0.04 | 0.06 | 0.01 | 0.00 | 0.00 | 0.15 | 0.01 |
| SDC1 | ENSG00000115884 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.13 | 0.01 | 0.00 | 0.00 | 0.03 | 0.05 | 0.05 | 0.02 | 0.11 | 0.03 | 0.04 | 0.02 | 0.08 | 0.04 | 0.10 | 0.04 | 0.01 | 0.01 | 0.00 | 0.02 | 0.01 | 0.04 | 0.15 | 0.00 | 0.00 | 0.05 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.05 | 0.22 | 0.15 | 0.11 | 0.01 | 0.13 | 0.03 | 0.25 | 0.03 | 0.03 | 0.11 | 0.18 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 | 0.02 | 0.01 | 0.04 | 0.02 | 0.05 | 0.00 | 0.01 | 0.04 |
| CDK11A | ENSG00000008128 | 0.00 | 0.05 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.03 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.09 | 0.06 | 0.08 | 0.11 | 0.06 | 0.09 | 0.13 | 0.08 | 0.09 | 0.09 | 0.02 | 0.11 | 0.00 | 0.17 | 0.05 | 0.05 | 0.02 | 0.31 | 0.00 | 1.01 | 0.05 | 0.17 | 0.01 | 0.12 | 0.00 | 0.00 | 0.04 | 0.19 | 0.23 | 0.38 | 0.06 | 0.11 | 0.05 | 0.12 | 0.08 | 0.27 | 0.18 | 0.28 | 0.10 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.14 | 0.07 | 0.13 |
| PRKCI | ENSG00000163558 | 0.07 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.10 | 0.01 | 0.20 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.23 | 0.01 | 1.74 | 0.00 | 0.61 | 0.00 | 0.90 | 0.00 | 0.33 | 0.00 | 0.03 | 0.01 | 0.04 | 0.01 | 0.08 | 0.00 | 0.15 | 0.01 | 0.12 | 0.03 | 0.10 | 0.00 | 0.00 | 0.07 | 0.00 | 0.00 | 0.26 | 0.01 | 1.46 | 0.02 | 0.76 | 0.00 | 0.44 | 0.00 | 1.19 | 0.04 | 0.06 | 0.07 | 0.19 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.04 | 0.01 | 0.05 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| CHD4 | ENSG00000111642 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.07 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.08 | 0.06 | 0.07 | 0.17 | 0.01 | 0.11 | 0.01 | 0.08 | 0.04 | 0.06 | 0.05 | 0.06 | 0.02 | 0.05 | 0.02 | 0.05 | 0.05 | 0.04 | 0.04 | 0.14 | 0.05 | 0.06 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.13 | 0.04 | 0.36 | 0.07 | 0.05 | 0.02 | 0.10 | 0.02 | 0.12 | 0.03 | 0.12 | 0.12 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.15 | 0.01 | 0.07 | 0.01 | 0.00 | 0.01 | 0.05 | 0.04 |
| LIFR | ENSG00000113594 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.03 | 0.13 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.21 | 0.01 | 0.23 | 0.01 | 0.10 | 0.00 | 0.15 | 0.01 | 0.18 | 0.01 | 0.05 | 0.01 | 0.05 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.25 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.07 | 0.02 | 0.24 | 0.02 | 0.07 | 0.00 | 0.08 | 0.01 | 0.15 | 0.03 | 0.31 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.21 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.18 | 0.02 |
| PTEN | ENSG00000171862 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.09 | 0.00 | 0.49 | 0.03 | 0.18 | 0.00 | 0.02 | 0.01 | 0.14 | 0.01 | 0.06 | 0.02 | 0.28 | 0.01 | 0.11 | 0.02 | 0.16 | 0.01 | 0.17 | 0.00 | 0.13 | 0.00 | 0.10 | 0.02 | 0.04 | 0.01 | 0.16 | 0.25 | 0.02 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.02 | 0.02 | 0.20 | 0.09 | 0.34 | 0.02 | 0.16 | 0.04 | 0.18 | 0.01 | 0.18 | 0.01 | 0.26 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | 0.21 | 0.00 | 0.07 | 0.01 | 0.38 | 0.00 | 0.00 | 0.01 | 0.34 |
| EZH2 | ENSG00000106462 | 0.03 | 0.01 | 0.06 | 0.00 | 0.05 | 0.02 | 0.02 | 0.02 | 0.03 | 0.05 | 0.00 | 0.01 | 0.03 | 0.03 | 0.10 | 0.02 | 0.08 | 0.08 | 0.03 | 0.16 | 0.03 | 0.24 | 0.02 | 0.10 | 0.02 | 0.01 | 0.04 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.11 | 0.03 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.07 | 0.55 | 0.09 | 0.03 | 0.09 | 0.04 | 0.06 | 0.11 | 0.16 | 0.15 | 0.15 | 0.01 | 0.05 | 0.00 | 0.06 | 0.00 | 0.13 | 0.11 | 0.01 | 0.07 | 0.01 | 0.00 | 0.03 | 0.21 | 0.03 |
| EPHB2 | ENSG00000133216 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.03 | 0.08 | 0.09 | 0.00 | 0.03 | 0.04 | 0.23 | 0.04 | 0.06 | 0.05 | 0.11 | 0.03 | 0.07 | 0.06 | 0.10 | 0.06 | 0.12 | 0.00 | 0.16 | 0.02 | 0.23 | 0.02 | 0.08 | 0.01 | 0.22 | 0.00 | 1.06 | 0.03 | 0.06 | 0.01 | 0.10 | 0.00 | 0.00 | 0.01 | 0.19 | 0.12 | 0.45 | 0.04 | 0.08 | 0.04 | 0.12 | 0.12 | 0.19 | 0.16 | 0.11 | 0.05 | 0.06 | 0.02 | 0.00 | 0.00 | 0.11 | 0.04 | 0.02 | 0.06 | 0.10 | 0.00 | 0.12 | 0.09 | 0.09 |
| ABL1 | ENSG00000097007 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.04 | 0.03 | 0.06 | 0.03 | 0.08 | 0.02 | 0.11 | 0.03 | 0.10 | 0.02 | 0.02 | 0.02 | 0.04 | 0.04 | 0.00 | 0.01 | 0.06 | 0.03 | 0.06 | 0.01 | 0.14 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.05 | 0.09 | 0.24 | 0.08 | 0.01 | 0.03 | 0.06 | 0.06 | 0.11 | 0.07 | 0.10 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.03 | 0.02 | 0.00 | 0.03 | 0.03 | 0.03 |
| EIF2AK4 | ENSG00000128829 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.07 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.37 | 0.01 | 0.12 | 0.01 | 0.10 | 0.02 | 0.05 | 0.03 | 0.05 | 0.02 | 0.08 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.04 | 0.01 | 0.03 | 0.00 | 0.07 | 0.02 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.12 | 0.04 | 0.36 | 0.00 | 0.10 | 0.01 | 0.10 | 0.11 | 0.54 | 0.04 | 0.09 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.10 | 0.00 | 0.02 | 0.01 | 0.13 | 0.00 | 0.00 | 0.02 | 0.18 |
| PSMA7 | ENSG00000101182 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.05 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.26 | 0.01 | 0.06 | 0.04 | 0.02 | 0.01 | 0.12 | 0.01 | 0.19 | 0.00 | 0.08 | 0.00 | 0.12 | 0.01 | 0.03 | 0.00 | 0.13 | 0.00 | 0.00 | 0.01 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.34 | 0.02 | 0.47 | 0.04 | 0.04 | 0.03 | 0.14 | 0.01 | 0.38 | 0.00 | 0.27 | 0.07 | 0.03 | 0.02 | 0.03 | 0.00 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.11 | 0.00 |
| CD19 | ENSG00000177455 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.19 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.07 | 0.01 | 0.09 | 0.01 | 0.03 | 0.01 | 0.06 | 0.00 | 0.04 | 0.00 | 0.03 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.08 | 0.03 | 0.02 | 0.03 | 0.09 | 0.01 | 0.34 | 0.03 | 0.05 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 |
| TUBA1C | ENSG00000167553 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.01 | 0.02 | 0.02 | 0.02 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.05 | 0.02 | 0.01 | 0.09 | 0.01 | 0.17 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.04 | 0.05 | 0.09 | 0.07 | 0.02 | 0.01 | 0.04 | 0.01 | 0.09 | 0.11 | 0.10 | 0.09 | 0.02 | 0.00 | 0.00 | 0.01 | 0.10 | 0.06 | 0.01 | 0.04 | 0.02 | 0.05 | 0.00 | 0.00 | 0.05 | 0.05 |
| SLC7A5 | ENSG00000103257 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.06 | 0.01 | 0.25 | 0.09 | 0.04 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.11 | 0.02 | 0.06 | 0.03 | 0.04 | 0.07 | 0.05 | 0.04 | 0.04 | 0.02 | 0.03 | 0.02 | 0.03 | 0.02 | 0.01 | 0.03 | 0.07 | 0.05 | 0.05 | 0.22 | 0.04 | 0.01 | 0.02 | 0.00 | 0.01 | 0.05 | 0.08 | 0.04 | 0.31 | 0.05 | 0.07 | 0.02 | 0.09 | 0.00 | 0.28 | 0.05 | 0.09 | 0.00 | 0.11 | 0.00 | 0.04 | 0.03 | 0.00 | 0.00 | 0.02 | 0.01 | 0.04 | 0.00 | 0.00 | 0.02 | 0.10 |
| P2RY12 | ENSG00000169313 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.10 | 0.02 | 0.86 | 0.01 | 0.44 | 0.00 | 0.53 | 0.02 | 0.11 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.02 | 0.00 | 0.08 | 0.01 | 0.03 | 0.03 | 0.09 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.16 | 0.01 | 0.69 | 0.02 | 0.41 | 0.00 | 0.14 | 0.01 | 0.23 | 0.07 | 0.05 | 0.09 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.03 | 0.04 |
| REL | ENSG00000162924 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.01 | 0.50 | 0.00 | 0.05 | 0.00 | 0.09 | 0.02 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.07 | 0.09 | 0.04 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 0.01 | 0.22 | 0.02 | 0.06 | 0.00 | 0.04 | 0.01 | 0.17 | 0.02 | 0.06 | 0.04 | 0.02 | 0.02 | 0.00 | 0.00 | 1.12 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
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