Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SRD5A2 | ENSG00000277893 | 0.00 | 0.00 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.08 | 0.01 | 0.00 | 0.00 | 0.03 | 0.07 | 0.05 | 0.02 | 0.10 | 0.02 | 0.03 | 0.01 | 0.04 | 0.04 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.03 | 0.07 | 0.01 | 0.00 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.22 | 0.06 | 0.08 | 0.00 | 0.08 | 0.01 | 0.16 | 0.00 | 0.08 | 0.05 | 0.13 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.01 | 0.05 | 0.00 | 0.01 | 0.02 |
| OR52E5 | ENSG00000277932 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.10 | 0.00 | 0.00 | 0.02 | 0.08 | 0.01 | 0.06 | 0.01 | 0.14 | 0.01 | 0.06 | 0.05 | 0.09 | 0.02 | 0.04 | 0.02 | 0.01 | 0.01 | 0.03 | 0.00 | 0.05 | 0.03 | 0.01 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.09 | 0.00 | 0.00 | 0.02 | 0.10 | 0.01 | 0.43 | 0.01 | 0.06 | 0.02 | 0.07 | 0.03 | 0.09 | 0.06 | 0.13 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.03 |
| DHRS11 | ENSG00000278535 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.05 | 0.06 | 0.00 | 0.03 | 0.05 | 0.02 | 0.03 | 0.09 | 0.07 | 0.18 | 0.01 | 0.06 | 0.02 | 0.05 | 0.01 | 0.05 | 0.01 | 0.03 | 0.04 | 0.05 | 0.01 | 0.03 | 0.10 | 0.00 | 0.13 | 0.00 | 0.00 | 0.14 | 0.09 | 0.05 | 0.18 | 0.00 | 0.02 | 0.06 | 0.07 | 0.11 | 0.08 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.04 | 0.00 | 0.03 | 0.01 | 0.03 |
| OR4F29 | ENSG00000278566 | 0.33 | 0.00 | 0.06 | 0.01 | 0.00 | 0.04 | 0.03 | 0.01 | 0.02 | 0.10 | 0.00 | 0.01 | 0.03 | 0.05 | 0.09 | 0.03 | 0.04 | 0.06 | 0.04 | 0.06 | 0.18 | 0.02 | 0.03 | 0.05 | 0.03 | 0.01 | 0.04 | 0.04 | 0.03 | 0.01 | 0.14 | 0.05 | 0.05 | 0.01 | 0.38 | 0.03 | 0.01 | 0.03 | 0.01 | 0.00 | 0.10 | 0.05 | 0.23 | 0.15 | 0.04 | 0.04 | 0.07 | 0.03 | 0.21 | 0.02 | 0.23 | 0.11 | 0.00 | 0.01 | 0.00 | 0.02 | 0.02 | 0.00 | 0.01 | 0.06 | 0.03 | 0.04 | 0.04 | 0.02 | 0.08 | 0.07 |
| NR2E3 | ENSG00000278570 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.01 | 0.02 | 0.05 | 0.03 | 0.00 | 0.00 | 0.09 | 0.02 | 0.04 | 0.02 | 0.06 | 0.02 | 0.03 | 0.03 | 0.06 | 0.05 | 0.07 | 0.03 | 0.02 | 0.00 | 0.01 | 0.03 | 0.03 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.03 | 0.25 | 0.13 | 0.10 | 0.02 | 0.03 | 0.08 | 0.17 | 0.22 | 0.07 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.11 | 0.00 |
| HIST1H4B | ENSG00000278705 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.24 | 0.03 | 0.00 | 0.01 | 0.02 | 0.05 | 0.07 | 0.02 | 0.07 | 0.05 | 0.02 | 0.04 | 0.10 | 0.11 | 0.04 | 0.05 | 0.03 | 0.03 | 0.04 | 0.03 | 0.03 | 0.03 | 0.12 | 0.01 | 0.06 | 0.08 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.14 | 0.03 | 0.39 | 0.05 | 0.09 | 0.04 | 0.05 | 0.01 | 0.20 | 0.05 | 0.04 | 0.07 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.02 | 0.01 | 0.00 | 0.13 | 0.00 | 0.14 | 0.01 |
| HIST1H3H | ENSG00000278828 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.19 | 0.02 | 0.00 | 0.01 | 0.02 | 0.05 | 0.06 | 0.02 | 0.06 | 0.05 | 0.02 | 0.04 | 0.09 | 0.09 | 0.06 | 0.05 | 0.04 | 0.02 | 0.06 | 0.02 | 0.02 | 0.03 | 0.10 | 0.01 | 0.06 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.32 | 0.06 | 0.09 | 0.03 | 0.05 | 0.01 | 0.26 | 0.02 | 0.04 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| OR51G1 | ENSG00000278870 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.03 | 0.05 | 0.02 | 0.06 | 0.02 | 0.14 | 0.01 | 0.07 | 0.04 | 0.10 | 0.02 | 0.05 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.06 | 0.03 | 0.03 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.00 | 0.02 | 0.11 | 0.01 | 0.43 | 0.01 | 0.05 | 0.02 | 0.07 | 0.03 | 0.09 | 0.04 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| OR2S2 | ENSG00000278889 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.13 | 0.03 | 0.00 | 0.01 | 0.01 | 0.08 | 0.06 | 0.03 | 0.38 | 0.04 | 0.27 | 0.04 | 0.22 | 0.04 | 0.18 | 0.02 | 0.02 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.03 | 0.02 | 0.19 | 0.01 | 0.14 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.11 | 0.06 | 0.02 | 0.01 | 0.05 | 0.01 | 0.03 | 0.11 | 0.11 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.05 | 0.06 | 0.00 | 0.03 | 0.09 | 0.05 |
| OR10A6 | ENSG00000279000 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.10 | 0.00 | 0.00 | 0.02 | 0.08 | 0.01 | 0.05 | 0.01 | 0.13 | 0.01 | 0.06 | 0.03 | 0.08 | 0.02 | 0.04 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.04 | 0.02 | 0.07 | 0.00 | 0.00 | 0.03 | 0.09 | 0.01 | 0.40 | 0.01 | 0.05 | 0.02 | 0.06 | 0.05 | 0.05 | 0.08 | 0.12 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.09 | 0.00 | 0.04 | 0.00 | 0.00 | 0.02 | 0.02 |
| OR51B2 | ENSG00000279012 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.09 | 0.01 | 0.06 | 0.01 | 0.14 | 0.02 | 0.06 | 0.01 | 0.11 | 0.02 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.08 | 0.00 | 0.00 | 0.02 | 0.10 | 0.01 | 0.43 | 0.01 | 0.05 | 0.02 | 0.07 | 0.03 | 0.09 | 0.04 | 0.16 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| OR6Q1 | ENSG00000279051 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.15 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.04 | 0.08 | 0.02 | 0.10 | 0.02 | 0.13 | 0.04 | 0.01 | 0.04 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.12 | 0.04 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.12 | 0.07 | 0.11 | 0.05 | 0.05 | 0.02 | 0.06 | 0.02 | 0.29 | 0.11 | 0.06 | 0.03 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.09 | 0.03 |
| OR10X1 | ENSG00000279111 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.38 | 0.02 | 0.02 | 0.00 | 0.11 | 0.00 | 0.27 | 0.00 | 0.24 | 0.00 | 0.06 | 0.00 | 0.24 | 0.02 | 0.12 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.07 | 0.00 | 0.28 | 0.00 | 0.35 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.23 | 0.01 | 0.38 | 0.02 | 0.15 | 0.00 | 0.13 | 0.00 | 0.28 | 0.00 | 0.39 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.15 | 0.02 |
| OR8D2 | ENSG00000279116 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.02 | 0.07 | 0.03 | 0.10 | 0.00 | 0.00 | 0.11 | 0.06 | 0.06 | 0.09 | 0.05 | 0.10 | 0.04 | 0.14 | 0.05 | 0.15 | 0.05 | 0.08 | 0.01 | 0.01 | 0.01 | 0.03 | 0.01 | 0.02 | 0.00 | 0.09 | 0.00 | 0.19 | 0.02 | 0.06 | 0.00 | 0.05 | 0.00 | 0.00 | 0.02 | 0.22 | 0.18 | 0.17 | 0.04 | 0.31 | 0.04 | 0.07 | 0.05 | 0.17 | 0.02 | 0.24 | 0.00 | 0.24 | 0.03 | 0.00 | 0.13 | 0.02 | 0.07 | 0.01 | 0.01 | 0.02 | 0.00 | 0.07 | 0.01 | 0.26 |
| OR52R1 | ENSG00000279270 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.03 | 0.05 | 0.02 | 0.06 | 0.02 | 0.14 | 0.01 | 0.07 | 0.02 | 0.10 | 0.02 | 0.05 | 0.02 | 0.02 | 0.01 | 0.02 | 0.00 | 0.07 | 0.04 | 0.03 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.00 | 0.02 | 0.11 | 0.01 | 0.43 | 0.01 | 0.05 | 0.02 | 0.07 | 0.03 | 0.09 | 0.04 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| OR2T11 | ENSG00000279301 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.04 | 0.14 | 0.04 | 0.02 | 0.02 | 0.08 | 0.05 | 0.13 | 0.01 | 0.17 | 0.03 | 0.10 | 0.02 | 0.27 | 0.04 | 0.13 | 0.01 | 0.04 | 0.02 | 0.08 | 0.01 | 0.02 | 0.01 | 0.20 | 0.02 | 0.23 | 0.02 | 0.10 | 0.07 | 0.00 | 0.04 | 0.00 | 0.00 | 0.29 | 0.02 | 0.48 | 0.12 | 0.13 | 0.01 | 0.12 | 0.02 | 0.32 | 0.00 | 0.09 | 0.24 | 0.06 | 0.02 | 0.01 | 0.00 | 0.03 | 0.18 | 0.02 | 0.04 | 0.02 | 0.04 | 0.15 | 0.03 | 0.24 | 0.02 |
| OR5L1 | ENSG00000279395 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.01 | 0.03 | 0.13 | 0.04 | 0.00 | 0.01 | 0.04 | 0.03 | 0.04 | 0.03 | 0.08 | 0.03 | 0.11 | 0.01 | 0.16 | 0.05 | 0.01 | 0.04 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.07 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.12 | 0.06 | 0.04 | 0.02 | 0.04 | 0.03 | 0.34 | 0.03 | 0.10 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.02 | 0.05 | 0.04 |
| OR2AG1 | ENSG00000279486 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.09 | 0.00 | 0.00 | 0.02 | 0.08 | 0.01 | 0.06 | 0.02 | 0.14 | 0.01 | 0.06 | 0.06 | 0.10 | 0.02 | 0.04 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.02 | 0.07 | 0.02 | 0.07 | 0.00 | 0.00 | 0.03 | 0.10 | 0.01 | 0.41 | 0.01 | 0.05 | 0.02 | 0.06 | 0.03 | 0.18 | 0.03 | 0.12 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.08 | 0.01 | 0.05 | 0.00 | 0.00 | 0.02 | 0.03 |
| OR4C16 | ENSG00000279514 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.01 | 0.03 | 0.13 | 0.04 | 0.00 | 0.01 | 0.04 | 0.03 | 0.04 | 0.03 | 0.08 | 0.03 | 0.11 | 0.01 | 0.16 | 0.05 | 0.01 | 0.04 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.07 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.12 | 0.06 | 0.04 | 0.02 | 0.04 | 0.03 | 0.34 | 0.03 | 0.10 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.02 | 0.05 | 0.04 |
| OR5R1 | ENSG00000279961 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.14 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.03 | 0.03 | 0.09 | 0.03 | 0.12 | 0.01 | 0.16 | 0.03 | 0.01 | 0.05 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.09 | 0.07 | 0.11 | 0.04 | 0.06 | 0.01 | 0.04 | 0.02 | 0.28 | 0.08 | 0.07 | 0.04 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.02 |
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