Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 161 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| OR4C45 | ENSG00000260811 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SULT1A3 | ENSG00000261052 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.17 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.01 | 0.09 | 0.01 | 0.03 | 0.01 | 0.12 | 0.00 | 0.05 | 0.00 | 0.05 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.01 | 0.12 | 0.03 | 0.02 | 0.02 | 0.10 | 0.01 | 0.34 | 0.05 | 0.04 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 |
| TUBB8 | ENSG00000261456 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.04 | 0.01 | 0.03 | 0.24 | 0.02 | 0.00 | 0.00 | 0.02 | 0.17 | 0.06 | 0.09 | 0.03 | 0.13 | 0.03 | 0.06 | 0.07 | 0.12 | 0.06 | 0.06 | 0.02 | 0.04 | 0.02 | 0.03 | 0.01 | 0.05 | 0.03 | 0.03 | 0.00 | 0.05 | 0.00 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.16 | 0.03 | 0.34 | 0.18 | 0.04 | 0.03 | 0.07 | 0.03 | 0.32 | 0.00 | 0.09 | 0.35 | 0.01 | 0.07 | 0.01 | 0.02 | 0.07 | 0.09 | 0.08 | 0.02 | 0.02 | 0.06 | 0.00 | 0.02 | 0.03 | 0.10 |
| HPR | ENSG00000261701 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.21 | 0.15 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 | 0.02 | 0.06 | 0.04 | 0.04 | 0.04 | 0.01 | 0.01 | 0.02 | 0.03 | 0.01 | 0.00 | 0.02 | 0.05 | 0.05 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.03 | 0.33 | 0.04 | 0.03 | 0.03 | 0.09 | 0.00 | 0.16 | 0.03 | 0.04 | 0.05 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.04 | 0.02 |
| MIA | ENSG00000261857 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.04 | 0.19 | 0.02 | 0.00 | 0.00 | 0.08 | 0.02 | 0.12 | 0.03 | 0.34 | 0.07 | 0.03 | 0.02 | 0.05 | 0.05 | 0.08 | 0.03 | 0.05 | 0.01 | 0.01 | 0.01 | 0.11 | 0.02 | 0.08 | 0.02 | 0.12 | 0.01 | 0.09 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.04 | 0.33 | 0.25 | 0.10 | 0.04 | 0.10 | 0.04 | 0.73 | 0.14 | 0.22 | 0.12 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.07 | 0.02 | 0.07 | 0.00 | 0.00 | 0.02 | 0.02 |
| OR1P1 | ENSG00000262085 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.07 | 0.02 | 0.02 | 0.01 | 0.03 | 0.03 | 0.04 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.13 | 0.00 | 0.03 | 0.02 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.05 | 0.14 | 0.09 | 0.02 | 0.03 | 0.03 | 0.04 | 0.06 | 0.13 | 0.16 | 0.22 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.02 | 0.04 |
| MMP12 | ENSG00000262406 | 0.01 | 0.01 | 0.00 | 0.05 | 0.03 | 0.03 | 0.02 | 0.04 | 0.25 | 0.07 | 0.00 | 0.01 | 0.06 | 0.06 | 0.11 | 0.05 | 0.10 | 0.07 | 0.37 | 0.10 | 0.21 | 0.07 | 0.07 | 0.05 | 0.02 | 0.01 | 0.02 | 0.04 | 0.05 | 0.01 | 0.05 | 0.05 | 0.00 | 0.10 | 0.00 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.06 | 0.19 | 0.35 | 0.13 | 0.77 | 0.11 | 0.05 | 0.05 | 0.07 | 0.30 | 0.23 | 0.14 | 0.01 | 0.08 | 0.02 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.13 | 0.13 |
| OR1D5 | ENSG00000262628 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.04 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.08 | 0.02 | 0.02 | 0.01 | 0.03 | 0.03 | 0.04 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.13 | 0.00 | 0.03 | 0.02 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.05 | 0.14 | 0.10 | 0.02 | 0.03 | 0.03 | 0.04 | 0.06 | 0.15 | 0.16 | 0.23 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.02 | 0.04 |
| OR52L2P | ENSG00000262980 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.01 | 0.00 | 0.10 | 0.00 | 0.00 | 0.02 | 0.08 | 0.01 | 0.06 | 0.02 | 0.14 | 0.01 | 0.06 | 0.05 | 0.09 | 0.02 | 0.04 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.00 | 0.02 | 0.10 | 0.01 | 0.42 | 0.01 | 0.06 | 0.02 | 0.07 | 0.03 | 0.09 | 0.04 | 0.13 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.09 | 0.01 | 0.06 | 0.00 | 0.00 | 0.01 | 0.03 |
| PPIAL4C | ENSG00000263464 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GDF2 | ENSG00000263761 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.08 | 0.05 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.02 | 0.08 | 0.03 | 0.05 | 0.03 | 0.11 | 0.08 | 0.03 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.15 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.04 | 0.11 | 0.13 | 0.01 | 0.02 | 0.02 | 0.03 | 0.05 | 0.06 | 0.07 | 0.10 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 |
| AKR1C8P | ENSG00000264006 | 0.02 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.34 | 0.03 | 0.00 | 0.01 | 0.02 | 0.14 | 0.10 | 0.07 | 0.06 | 0.13 | 0.02 | 0.07 | 0.11 | 0.10 | 0.08 | 0.03 | 0.03 | 0.03 | 0.02 | 0.00 | 0.03 | 0.03 | 0.04 | 0.03 | 0.00 | 0.05 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.17 | 0.02 | 0.35 | 0.11 | 0.03 | 0.03 | 0.04 | 0.01 | 0.15 | 0.00 | 0.06 | 0.10 | 0.01 | 0.03 | 0.00 | 0.00 | 0.07 | 0.07 | 0.06 | 0.01 | 0.03 | 0.01 | 0.00 | 0.02 | 0.03 | 0.03 |
| RBP3 | ENSG00000265203 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.07 | 0.07 | 0.05 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.02 | 0.08 | 0.03 | 0.05 | 0.03 | 0.11 | 0.08 | 0.03 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.15 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.05 | 0.11 | 0.14 | 0.01 | 0.02 | 0.02 | 0.03 | 0.05 | 0.06 | 0.07 | 0.10 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 |
| BAHCC1 | ENSG00000266074 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PNLIPRP2 | ENSG00000266200 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.03 | 0.10 | 0.00 | 0.02 | 0.01 | 0.17 | 0.02 | 0.02 | 0.04 | 0.05 | 0.01 | 0.03 | 0.04 | 0.06 | 0.07 | 0.06 | 0.01 | 0.06 | 0.01 | 0.05 | 0.01 | 0.01 | 0.02 | 0.10 | 0.14 | 0.25 | 0.11 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.03 | 0.09 | 0.15 | 0.22 | 0.01 | 0.06 | 0.05 | 0.06 | 0.04 | 0.05 | 0.04 | 0.05 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.12 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.05 |
| GDF10 | ENSG00000266524 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.08 | 0.05 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.02 | 0.08 | 0.03 | 0.05 | 0.03 | 0.11 | 0.08 | 0.03 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.15 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.04 | 0.11 | 0.13 | 0.01 | 0.02 | 0.02 | 0.03 | 0.05 | 0.06 | 0.07 | 0.10 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 |
| LCN6 | ENSG00000267206 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.07 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.03 | 0.08 | 0.02 | 0.08 | 0.05 | 0.20 | 0.01 | 0.15 | 0.02 | 0.03 | 0.01 | 0.10 | 0.04 | 0.01 | 0.00 | 0.07 | 0.04 | 0.06 | 0.01 | 0.16 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.06 | 0.06 | 0.20 | 0.22 | 0.06 | 0.02 | 0.09 | 0.04 | 0.18 | 0.09 | 0.06 | 0.17 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.04 | 0.03 |
| GABRQ | ENSG00000268089 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.10 | 0.04 | 0.06 | 0.00 | 0.06 | 0.01 | 0.21 | 0.01 | 0.17 | 0.02 | 0.14 | 0.00 | 0.16 | 0.01 | 0.16 | 0.02 | 0.05 | 0.00 | 0.10 | 0.02 | 0.06 | 0.02 | 0.12 | 0.03 | 0.10 | 0.01 | 0.15 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.03 | 0.41 | 0.10 | 0.21 | 0.03 | 0.09 | 0.03 | 0.09 | 0.07 | 0.18 | 0.07 | 0.01 | 0.02 | 0.00 | 0.00 | 0.15 | 0.07 | 0.02 | 0.03 | 0.03 | 0.01 | 0.05 | 0.00 | 0.07 | 0.02 |
| SLC6A14 | ENSG00000268104 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.03 | 0.03 | 0.00 | 0.00 | 0.01 | 0.06 | 0.01 | 0.10 | 0.01 | 0.05 | 0.01 | 0.12 | 0.01 | 0.06 | 0.03 | 0.03 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.07 | 0.01 | 0.03 | 0.11 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.10 | 0.05 | 0.06 | 0.01 | 0.02 | 0.01 | 0.01 | 0.02 | 0.09 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 |
| OPN1MW | ENSG00000268221 | 0.03 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.12 | 0.04 | 0.06 | 0.00 | 0.06 | 0.01 | 0.23 | 0.01 | 0.19 | 0.03 | 0.15 | 0.00 | 0.23 | 0.02 | 0.16 | 0.02 | 0.05 | 0.00 | 0.10 | 0.01 | 0.06 | 0.00 | 0.13 | 0.03 | 0.10 | 0.01 | 0.17 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.03 | 0.46 | 0.10 | 0.23 | 0.02 | 0.11 | 0.03 | 0.09 | 0.07 | 0.23 | 0.08 | 0.01 | 0.02 | 0.00 | 0.00 | 0.15 | 0.07 | 0.02 | 0.03 | 0.03 | 0.01 | 0.05 | 0.00 | 0.07 | 0.01 |
|
Showing page 161 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.