Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
 HGNC Symbol  Ensembl Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
IGLL5ENSG00000254709  0.00    0.00    0.00    0.01    0.00    0.00    0.01    0.02    0.20    0.04    0.02    0.01    0.01    0.05    0.10    0.03    0.18    0.03    0.05    0.01    0.07    0.02    0.04    0.02    0.02    0.01    0.05    0.05    0.00    0.04    0.01    0.04    0.03    0.05    0.04    0.06    0.00    0.01    0.00    0.00    0.06    0.04    0.19    0.08    0.02    0.00    0.07    0.03    0.39    0.03    0.14    0.05    0.22    0.02    0.00    0.00    0.00    0.00    0.02    0.01    0.01    0.03    0.00    0.00    0.10    0.03  
OR10G4ENSG00000254737  0.00    0.01    0.00    0.05    0.02    0.02    0.02    0.06    0.03    0.09    0.00    0.00    0.13    0.06    0.05    0.09    0.05    0.10    0.04    0.14    0.05    0.15    0.05    0.08    0.01    0.01    0.01    0.03    0.01    0.02    0.00    0.09    0.00    0.19    0.00    0.04    0.00    0.05    0.00    0.00    0.03    0.22    0.19    0.17    0.04    0.31    0.04    0.07    0.05    0.17    0.05    0.24    0.00    0.24    0.03    0.00    0.13    0.02    0.06    0.01    0.01    0.01    0.00    0.07    0.01    0.26  
OR5M10ENSG00000254834  0.01    0.00    0.00    0.01    0.08    0.00    0.00    0.02    0.14    0.03    0.00    0.00    0.06    0.03    0.03    0.03    0.09    0.02    0.13    0.01    0.18    0.03    0.01    0.05    0.01    0.01    0.01    0.02    0.00    0.02    0.04    0.02    0.05    0.07    0.05    0.00    0.00    0.01    0.00    0.00    0.10    0.06    0.12    0.05    0.06    0.02    0.03    0.02    0.28    0.08    0.09    0.04    0.01    0.03    0.00    0.00    0.00    0.02    0.00    0.01    0.01    0.02    0.00    0.00    0.04    0.02  
OR5M1ENSG00000255012  0.01    0.00    0.00    0.01    0.08    0.00    0.00    0.02    0.15    0.03    0.00    0.00    0.06    0.04    0.03    0.03    0.09    0.02    0.13    0.01    0.18    0.03    0.01    0.05    0.01    0.01    0.01    0.02    0.00    0.02    0.02    0.02    0.05    0.07    0.05    0.00    0.00    0.01    0.00    0.00    0.10    0.06    0.12    0.05    0.06    0.02    0.03    0.02    0.28    0.08    0.09    0.04    0.01    0.03    0.00    0.00    0.00    0.02    0.00    0.01    0.01    0.02    0.00    0.00    0.05    0.02  
OR1D4ENSG00000255095  0.00    0.00    0.00    0.00    0.00    0.00    0.01    0.06    0.04    0.03    0.00    0.00    0.01    0.02    0.01    0.07    0.02    0.02    0.01    0.03    0.03    0.04    0.02    0.03    0.01    0.00    0.00    0.00    0.00    0.03    0.01    0.13    0.00    0.03    0.02    0.03    0.00    0.03    0.00    0.00    0.03    0.05    0.14    0.09    0.01    0.03    0.03    0.04    0.06    0.13    0.16    0.23    0.00    0.02    0.00    0.02    0.00    0.06    0.00    0.00    0.00    0.05    0.00    0.00    0.02    0.03  
OR5M11ENSG00000255223  0.01    0.00    0.00    0.01    0.08    0.00    0.00    0.02    0.14    0.03    0.00    0.00    0.06    0.03    0.03    0.03    0.09    0.02    0.12    0.01    0.15    0.03    0.01    0.05    0.03    0.00    0.01    0.02    0.00    0.02    0.04    0.02    0.05    0.07    0.05    0.00    0.00    0.01    0.00    0.00    0.09    0.06    0.12    0.05    0.06    0.02    0.03    0.02    0.28    0.08    0.10    0.04    0.01    0.03    0.00    0.00    0.00    0.02    0.00    0.01    0.01    0.02    0.00    0.00    0.04    0.02  
OR52B2ENSG00000255307  0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.01    0.00    0.10    0.00    0.00    0.02    0.08    0.01    0.06    0.02    0.14    0.01    0.06    0.05    0.09    0.04    0.04    0.02    0.01    0.01    0.02    0.00    0.05    0.03    0.02    0.03    0.01    0.01    0.07    0.02    0.07    0.00    0.00    0.02    0.10    0.01    0.42    0.01    0.06    0.02    0.07    0.03    0.09    0.04    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.09    0.01    0.06    0.02    0.00    0.01    0.03  
TAS2R43ENSG00000255374  0.01    0.00    0.00    0.01    0.00    0.00    0.01    0.16    0.04    0.08    0.01    0.00    0.00    0.05    0.04    0.10    0.12    0.01    0.09    0.03    0.05    0.04    0.03    0.08    0.01    0.03    0.03    0.03    0.01    0.06    0.00    0.06    0.14    0.05    0.03    0.00    0.00    0.01    0.00    0.00    0.11    0.06    0.32    0.10    0.01    0.02    0.04    0.03    0.04    0.03    0.12    0.16    0.54    0.00    0.00    0.03    0.00    0.04    0.09    0.01    0.01    0.05    0.00    0.01    0.04    0.03  
HCAR3ENSG00000255398  0.01    0.01    0.02    0.00    0.07    0.02    0.03    0.05    0.08    0.03    0.00    0.00    0.01    0.02    0.04    0.05    0.02    0.06    0.03    0.03    0.10    0.04    0.05    0.04    0.01    0.01    0.04    0.03    0.00    0.06    0.03    0.09    0.00    0.17    0.10    0.01    0.00    0.03    0.00    0.00    0.03    0.08    0.13    0.24    0.02    0.02    0.03    0.07    0.17    0.27    0.12    0.05    0.01    0.00    0.00    0.00    0.07    0.06    0.03    0.01    0.02    0.00    0.00    0.00    0.03    0.07  
OR10G2ENSG00000255582  0.00    0.01    0.00    0.02    0.00    0.00    0.00    0.03    0.10    0.06    0.00    0.00    0.00    0.05    0.14    0.02    0.12    0.08    0.08    0.07    0.09    0.08    0.07    0.04    0.03    0.02    0.01    0.07    0.01    0.05    0.07    0.00    0.00    0.02    0.27    0.03    0.01    0.02    0.00    0.00    0.09    0.03    0.36    0.08    0.08    0.01    0.06    0.04    0.20    0.10    0.18    0.07    0.02    0.01    0.00    0.01    0.00    0.00    0.03    0.03    0.00    0.09    0.00    0.00    0.03    0.02  
OR4D2ENSG00000255713  0.01    0.00    0.05    0.00    0.00    0.00    0.02    0.05    0.17    0.02    0.02    0.00    0.11    0.00    0.10    0.01    0.13    0.02    0.04    0.02    0.14    0.04    0.05    0.03    0.04    0.01    0.07    0.04    0.01    0.15    0.16    0.00    0.12    0.01    0.10    0.03    0.02    0.00    0.00    0.00    0.46    0.02    0.16    0.03    0.11    0.01    0.10    0.03    0.19    0.02    0.18    0.03    0.01    0.00    0.00    0.00    0.00    0.02    0.06    0.00    0.04    0.00    0.17    0.00    0.20    0.02  
OR6J1ENSG00000255804  0.00    0.00    0.00    0.02    0.00    0.00    0.00    0.03    0.12    0.06    0.00    0.00    0.00    0.02    0.15    0.02    0.12    0.08    0.06    0.07    0.09    0.08    0.08    0.04    0.03    0.02    0.01    0.07    0.01    0.04    0.08    0.00    0.00    0.02    0.27    0.03    0.00    0.02    0.00    0.00    0.11    0.03    0.28    0.12    0.09    0.02    0.06    0.04    0.08    0.10    0.16    0.06    0.02    0.01    0.00    0.01    0.00    0.00    0.03    0.03    0.02    0.10    0.00    0.00    0.03    0.02  
MTRNR2L8ENSG00000255823  0.00    0.00    0.00    0.00    0.03    0.03    0.00    0.01    0.02    0.09    0.00    0.00    0.02    0.04    0.04    0.05    0.03    0.13    0.02    0.05    0.05    0.08    0.03    0.03    0.01    0.01    0.01    0.01    0.01    0.03    0.04    0.01    0.00    0.03    0.01    0.04    0.02    0.06    0.00    0.00    0.04    0.09    0.02    0.38    0.01    0.05    0.03    0.06    0.03    0.05    0.05    0.12    0.02    0.00    0.00    0.00    0.02    0.00    0.01    0.08    0.00    0.04    0.00    0.00    0.03    0.03  
TAS2R20ENSG00000255837  0.01    0.00    0.00    0.01    0.00    0.00    0.01    0.16    0.04    0.08    0.01    0.00    0.00    0.05    0.04    0.10    0.12    0.01    0.10    0.03    0.05    0.04    0.03    0.08    0.01    0.03    0.03    0.03    0.01    0.06    0.00    0.06    0.14    0.05    0.03    0.00    0.00    0.01    0.00    0.00    0.10    0.06    0.34    0.10    0.01    0.02    0.03    0.03    0.04    0.03    0.12    0.16    0.55    0.00    0.00    0.03    0.00    0.04    0.09    0.01    0.02    0.05    0.00    0.01    0.04    0.03  
CTSOENSG00000256043  0.01    0.03    0.00    0.01    0.06    0.02    0.03    0.04    0.05    0.12    0.00    0.02    0.00    0.05    0.04    0.06    0.02    0.11    0.01    0.10    0.05    0.08    0.06    0.07    0.01    0.07    0.02    0.03    0.03    0.03    0.07    0.07    0.00    0.12    0.10    0.05    0.00    0.03    0.00    0.00    0.05    0.07    0.06    0.26    0.02    0.08    0.02    0.05    0.10    0.05    0.11    0.13    0.01    0.04    0.00    0.00    0.03    0.03    0.00    0.09    0.00    0.03    0.00    0.00    0.05    0.06  
MTRNR2L10ENSG00000256045  0.01    0.00    0.01    0.01    0.00    0.00    0.01    0.01    0.03    0.02    0.00    0.00    0.00    0.01    0.04    0.01    0.07    0.03    0.06    0.02    0.07    0.03    0.03    0.01    0.03    0.00    0.00    0.00    0.00    0.00    0.01    0.00    0.00    0.01    0.13    0.00    0.03    0.00    0.00    0.00    0.08    0.00    0.21    0.03    0.01    0.02    0.05    0.02    0.23    0.03    0.18    0.02    0.02    0.00    0.00    0.00    0.07    0.00    0.07    0.00    0.03    0.00    0.03    0.00    0.02    0.00  
TAS2R30ENSG00000256188  0.01    0.00    0.00    0.01    0.00    0.00    0.01    0.16    0.04    0.08    0.01    0.00    0.00    0.05    0.04    0.10    0.12    0.01    0.09    0.03    0.05    0.04    0.03    0.08    0.01    0.03    0.03    0.03    0.01    0.06    0.00    0.06    0.14    0.05    0.03    0.00    0.00    0.01    0.00    0.00    0.11    0.06    0.32    0.10    0.01    0.02    0.04    0.03    0.04    0.03    0.12    0.16    0.54    0.00    0.00    0.03    0.00    0.04    0.09    0.01    0.01    0.05    0.00    0.01    0.04    0.03  
MTRNR2L3ENSG00000256222  0.01    0.00    0.00    0.00    0.00    0.00    0.05    0.01    0.06    0.03    0.00    0.00    0.03    0.00    0.22    0.02    0.08    0.03    0.01    0.01    0.11    0.01    0.21    0.00    0.13    0.00    0.10    0.00    0.03    0.00    0.10    0.00    0.00    0.01    0.04    0.02    0.00    0.00    0.00    0.00    0.40    0.01    0.41    0.04    0.04    0.02    0.10    0.01    0.21    0.00    0.21    0.05    0.03    0.00    0.00    0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.00    0.00    0.11    0.00  
ASIC5ENSG00000256394  0.01    0.03    0.00    0.01    0.06    0.02    0.03    0.03    0.05    0.13    0.00    0.02    0.00    0.01    0.04    0.06    0.02    0.11    0.02    0.10    0.05    0.08    0.05    0.07    0.01    0.07    0.02    0.03    0.03    0.03    0.06    0.07    0.00    0.12    0.10    0.05    0.00    0.03    0.00    0.00    0.06    0.07    0.06    0.26    0.02    0.08    0.02    0.05    0.10    0.05    0.11    0.13    0.01    0.03    0.00    0.00    0.03    0.03    0.00    0.09    0.00    0.03    0.00    0.00    0.05    0.06  
TAS2R31ENSG00000256436  0.01    0.00    0.00    0.01    0.00    0.00    0.01    0.16    0.04    0.08    0.01    0.00    0.00    0.05    0.04    0.10    0.12    0.01    0.10    0.03    0.05    0.04    0.03    0.08    0.01    0.03    0.03    0.03    0.01    0.06    0.00    0.06    0.14    0.05    0.03    0.00    0.00    0.01    0.00    0.00    0.10    0.06    0.33    0.10    0.01    0.02    0.03    0.03    0.04    0.03    0.12    0.16    0.55    0.00    0.00    0.03    0.00    0.04    0.09    0.01    0.01    0.05    0.00    0.01    0.04    0.03  

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