Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 158 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| UGT1A7 | ENSG00000244122 | 0.01 | 0.08 | 0.04 | 0.05 | 0.00 | 0.05 | 0.01 | 0.04 | 0.01 | 0.33 | 0.00 | 0.04 | 0.00 | 0.08 | 0.03 | 0.05 | 0.02 | 0.20 | 0.01 | 0.19 | 0.05 | 0.16 | 0.03 | 0.08 | 0.02 | 0.03 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 | 0.06 | 0.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.10 | 0.17 | 0.23 | 0.01 | 0.39 | 0.03 | 0.06 | 0.13 | 0.06 | 0.04 | 0.40 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.05 | 0.01 | 0.08 | 0.01 | 0.12 |
| P2RY11 | ENSG00000244165 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.09 | 0.04 | 0.00 | 0.01 | 0.09 | 0.01 | 0.03 | 0.04 | 0.07 | 0.06 | 0.05 | 0.05 | 0.08 | 0.06 | 0.04 | 0.05 | 0.02 | 0.01 | 0.01 | 0.04 | 0.01 | 0.03 | 0.02 | 0.11 | 0.00 | 0.01 | 0.10 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.10 | 0.04 | 0.57 | 0.20 | 0.11 | 0.06 | 0.18 | 0.09 | 0.56 | 0.21 | 0.31 | 0.03 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.02 | 0.02 | 0.01 |
| CFHR1 | ENSG00000244414 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.14 | 0.05 | 0.02 | 0.00 | 0.10 | 0.00 | 0.10 | 0.01 | 0.09 | 0.01 | 0.05 | 0.01 | 0.11 | 0.07 | 0.05 | 0.02 | 0.04 | 0.00 | 0.11 | 0.02 | 0.01 | 0.00 | 0.20 | 0.01 | 0.20 | 0.02 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.18 | 0.01 | 0.27 | 0.06 | 0.07 | 0.00 | 0.07 | 0.01 | 0.07 | 0.03 | 0.12 | 0.11 | 0.06 | 0.00 | 0.01 | 0.01 | 0.26 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.06 | 0.00 | 0.17 | 0.03 |
| IGKV3-15 | ENSG00000244437 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.02 | 0.09 | 0.02 | 0.07 | 0.02 | 0.10 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.02 | 0.08 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.11 | 0.05 | 0.04 | 0.01 | 0.05 | 0.02 | 0.08 | 0.02 | 0.20 | 0.05 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 |
| UGT1A4 | ENSG00000244474 | 0.01 | 0.08 | 0.04 | 0.05 | 0.00 | 0.05 | 0.01 | 0.04 | 0.01 | 0.33 | 0.00 | 0.04 | 0.00 | 0.08 | 0.03 | 0.05 | 0.02 | 0.20 | 0.01 | 0.19 | 0.05 | 0.16 | 0.03 | 0.08 | 0.02 | 0.03 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 | 0.06 | 0.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.10 | 0.17 | 0.23 | 0.01 | 0.39 | 0.03 | 0.06 | 0.13 | 0.06 | 0.04 | 0.40 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.05 | 0.01 | 0.08 | 0.01 | 0.12 |
| ASPRV1 | ENSG00000244617 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.01 | 0.17 | 0.00 | 0.04 | 0.00 | 0.09 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.03 | 0.03 | 0.00 | 0.08 | 0.03 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.01 | 0.15 | 0.05 | 0.04 | 0.01 | 0.07 | 0.01 | 0.23 | 0.00 | 0.06 | 0.04 | 0.03 | 0.05 | 0.00 | 0.00 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 |
| OR2AE1 | ENSG00000244623 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.08 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.12 | 0.02 | 0.24 | 0.01 | 0.24 | 0.00 | 0.51 | 0.02 | 0.32 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.11 | 0.01 | 0.09 | 0.01 | 0.11 | 0.01 | 0.10 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.07 | 0.03 | 0.21 | 0.05 | 0.07 | 0.01 | 0.07 | 0.02 | 0.15 | 0.03 | 0.07 | 0.04 | 0.09 | 0.01 | 0.00 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 |
| C4A | ENSG00000244731 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.04 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.02 | 0.06 | 0.05 | 0.03 | 0.04 | 0.13 | 0.05 | 0.12 | 0.04 | 0.03 | 0.02 | 0.07 | 0.02 | 0.05 | 0.01 | 0.11 | 0.01 | 0.05 | 0.03 | 0.08 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.03 | 0.29 | 0.06 | 0.17 | 0.01 | 0.05 | 0.01 | 0.10 | 0.03 | 0.06 | 0.07 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.17 | 0.01 | 0.01 | 0.00 | 0.01 | 0.11 | 0.00 | 0.12 | 0.01 |
| HBB | ENSG00000244734 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.05 | 0.01 | 0.06 | 0.02 | 0.14 | 0.01 | 0.06 | 0.02 | 0.10 | 0.03 | 0.06 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.07 | 0.00 | 0.01 | 0.02 | 0.10 | 0.01 | 0.43 | 0.01 | 0.05 | 0.02 | 0.07 | 0.03 | 0.09 | 0.04 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| ADH1C | ENSG00000248144 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.05 | 0.05 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.03 | 0.04 | 0.05 | 0.01 | 0.02 | 0.02 | 0.09 | 0.02 | 0.04 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.03 | 0.11 | 0.00 | 0.03 | 0.04 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.05 | 0.02 | 0.28 | 0.01 | 0.02 | 0.02 | 0.04 | 0.00 | 0.11 | 0.05 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 |
| CDK11B | ENSG00000248333 | 0.00 | 0.05 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.03 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.09 | 0.06 | 0.08 | 0.11 | 0.06 | 0.09 | 0.13 | 0.08 | 0.09 | 0.09 | 0.02 | 0.11 | 0.00 | 0.17 | 0.05 | 0.05 | 0.02 | 0.31 | 0.00 | 1.01 | 0.05 | 0.17 | 0.01 | 0.12 | 0.00 | 0.00 | 0.04 | 0.19 | 0.23 | 0.38 | 0.06 | 0.11 | 0.05 | 0.12 | 0.08 | 0.27 | 0.18 | 0.28 | 0.10 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.14 | 0.07 | 0.13 |
| MTRNR2L5 | ENSG00000249860 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.06 | 0.03 | 0.07 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.03 | 0.04 | 0.05 | 0.05 | 0.03 | 0.07 | 0.10 | 0.04 | 0.03 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.09 | 0.01 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.02 | 0.07 | 0.04 | 0.11 | 0.17 | 0.02 | 0.03 | 0.03 | 0.06 | 0.28 | 0.12 | 0.03 | 0.11 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 |
| GYPB | ENSG00000250361 | 0.03 | 0.02 | 0.00 | 0.01 | 0.06 | 0.00 | 0.02 | 0.01 | 0.11 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.03 | 0.03 | 0.11 | 0.03 | 0.04 | 0.14 | 0.04 | 0.09 | 0.04 | 0.01 | 0.02 | 0.02 | 0.02 | 0.00 | 0.02 | 0.06 | 0.05 | 0.00 | 0.03 | 0.10 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.03 | 0.05 | 0.03 | 0.02 | 0.04 | 0.04 | 0.11 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.01 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| CDK3 | ENSG00000250506 | 0.02 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.04 | 0.03 | 0.22 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.15 | 0.02 | 0.24 | 0.01 | 0.09 | 0.03 | 0.19 | 0.07 | 0.06 | 0.04 | 0.04 | 0.01 | 0.06 | 0.03 | 0.04 | 0.10 | 0.25 | 0.00 | 0.08 | 0.01 | 0.16 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.37 | 0.03 | 0.35 | 0.04 | 0.24 | 0.03 | 0.17 | 0.02 | 0.61 | 0.04 | 0.24 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.09 | 0.00 | 0.05 | 0.01 | 0.14 | 0.01 | 0.24 | 0.02 |
| OR7E85P | ENSG00000250884 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.03 | 0.04 | 0.05 | 0.03 | 0.06 | 0.09 | 0.05 | 0.06 | 0.04 | 0.02 | 0.03 | 0.02 | 0.03 | 0.02 | 0.01 | 0.03 | 0.04 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.04 | 0.21 | 0.06 | 0.01 | 0.03 | 0.04 | 0.03 | 0.13 | 0.00 | 0.06 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.05 | 0.03 |
| IGKV1D-39 | ENSG00000251546 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.02 | 0.09 | 0.02 | 0.07 | 0.02 | 0.10 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.02 | 0.08 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.11 | 0.05 | 0.04 | 0.01 | 0.05 | 0.02 | 0.08 | 0.02 | 0.20 | 0.05 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 |
| SLC10A5 | ENSG00000253598 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.00 | 0.10 | 0.00 | 0.17 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.01 | 0.13 | 0.03 | 0.04 | 0.00 | 0.10 | 0.00 | 0.11 | 0.01 | 0.11 | 0.00 | 0.16 | 0.01 | 0.01 | 0.01 | 0.11 | 0.00 | 0.19 | 0.01 | 0.06 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.25 | 0.01 | 0.24 | 0.10 | 0.04 | 0.01 | 0.05 | 0.01 | 0.15 | 0.02 | 0.19 | 0.05 | 0.14 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.22 | 0.00 | 0.12 | 0.01 |
| PRKDC | ENSG00000253729 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.03 | 0.04 | 0.16 | 0.04 | 0.00 | 0.00 | 0.00 | 0.07 | 0.15 | 0.02 | 0.15 | 0.03 | 0.16 | 0.01 | 0.08 | 0.02 | 0.06 | 0.02 | 0.07 | 0.04 | 0.08 | 0.06 | 0.04 | 0.00 | 0.10 | 0.02 | 0.12 | 0.02 | 0.03 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.19 | 0.03 | 0.28 | 0.03 | 0.04 | 0.02 | 0.09 | 0.01 | 0.81 | 0.07 | 0.20 | 0.04 | 0.11 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.24 | 0.00 | 0.09 | 0.02 |
| OR4D10 | ENSG00000254466 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.02 | 0.01 | 0.10 | 0.02 | 0.00 | 0.00 | 0.07 | 0.04 | 0.03 | 0.03 | 0.07 | 0.02 | 0.10 | 0.03 | 0.07 | 0.04 | 0.02 | 0.04 | 0.01 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.05 | 0.01 | 0.13 | 0.17 | 0.08 | 0.06 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 |
| INS | ENSG00000254647 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.01 | 0.02 | 0.01 | 0.11 | 0.00 | 0.00 | 0.02 | 0.05 | 0.03 | 0.07 | 0.01 | 0.16 | 0.02 | 0.07 | 0.02 | 0.15 | 0.06 | 0.06 | 0.20 | 0.01 | 0.23 | 0.03 | 0.01 | 0.06 | 0.04 | 0.03 | 0.03 | 0.01 | 0.08 | 0.05 | 0.04 | 0.06 | 0.00 | 0.00 | 0.03 | 0.12 | 0.05 | 0.47 | 0.01 | 0.07 | 0.04 | 0.08 | 0.23 | 0.09 | 0.04 | 0.16 | 0.02 | 0.04 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.06 | 0.00 | 0.00 | 0.01 | 0.04 |
|
Showing page 158 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.