Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| HLA-G | ENSG00000204632 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.16 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.06 | 0.06 | 0.02 | 0.04 | 0.11 | 0.09 | 0.09 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.05 | 0.01 | 0.13 | 0.00 | 0.06 | 0.03 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.09 | 0.03 | 0.30 | 0.06 | 0.09 | 0.04 | 0.04 | 0.01 | 0.17 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| NMS | ENSG00000204640 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.10 | 0.01 | 0.07 | 0.01 | 0.12 | 0.02 | 0.06 | 0.02 | 0.00 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.17 | 0.06 | 0.03 | 0.01 | 0.04 | 0.01 | 0.17 | 0.00 | 0.13 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 |
| OR2H2 | ENSG00000204657 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.06 | 0.05 | 0.02 | 0.04 | 0.16 | 0.08 | 0.10 | 0.04 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.09 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.32 | 0.06 | 0.09 | 0.04 | 0.03 | 0.01 | 0.17 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| IL31 | ENSG00000204671 | 0.01 | 0.01 | 0.02 | 0.00 | 0.07 | 0.02 | 0.04 | 0.05 | 0.10 | 0.04 | 0.00 | 0.00 | 0.01 | 0.03 | 0.03 | 0.06 | 0.02 | 0.06 | 0.03 | 0.03 | 0.08 | 0.04 | 0.07 | 0.04 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.06 | 0.04 | 0.08 | 0.00 | 0.17 | 0.11 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.09 | 0.13 | 0.23 | 0.01 | 0.02 | 0.03 | 0.08 | 0.12 | 0.27 | 0.20 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.06 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.07 |
| AKT1S1 | ENSG00000204673 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.10 | 0.03 | 0.00 | 0.02 | 0.00 | 0.06 | 0.01 | 0.07 | 0.06 | 0.10 | 0.03 | 0.02 | 0.07 | 0.03 | 0.07 | 0.03 | 0.01 | 0.03 | 0.01 | 0.03 | 0.03 | 0.05 | 0.03 | 0.03 | 0.00 | 0.07 | 0.23 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.10 | 0.04 | 0.04 | 0.32 | 0.05 | 0.07 | 0.04 | 0.06 | 0.11 | 0.15 | 0.03 | 0.18 | 0.00 | 0.04 | 0.01 | 0.00 | 0.10 | 0.06 | 0.00 | 0.14 | 0.02 | 0.13 | 0.00 | 0.00 | 0.02 | 0.02 |
| GABBR1 | ENSG00000204681 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.06 | 0.05 | 0.02 | 0.04 | 0.16 | 0.08 | 0.10 | 0.04 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.09 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.32 | 0.06 | 0.09 | 0.04 | 0.03 | 0.01 | 0.17 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| MAS1L | ENSG00000204687 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.02 | 0.06 | 0.05 | 0.03 | 0.04 | 0.16 | 0.08 | 0.10 | 0.04 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.32 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| OR11A1 | ENSG00000204694 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.16 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.02 | 0.06 | 0.06 | 0.03 | 0.04 | 0.15 | 0.08 | 0.09 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.31 | 0.05 | 0.09 | 0.04 | 0.03 | 0.01 | 0.26 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.13 | 0.01 |
| OR14J1 | ENSG00000204695 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.07 | 0.05 | 0.03 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.11 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.31 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| OR2J2 | ENSG00000204700 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.15 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.07 | 0.05 | 0.02 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.11 | 0.02 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.03 | 0.32 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| OR2J3 | ENSG00000204701 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.14 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.07 | 0.05 | 0.02 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.32 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.06 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| OR2J1 | ENSG00000204702 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.14 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.07 | 0.05 | 0.02 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.32 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.06 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| OR2B3 | ENSG00000204703 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.14 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.02 | 0.07 | 0.05 | 0.02 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.01 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.33 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.06 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| OR2W1 | ENSG00000204704 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.14 | 0.02 | 0.00 | 0.00 | 0.02 | 0.07 | 0.07 | 0.02 | 0.06 | 0.05 | 0.02 | 0.04 | 0.13 | 0.08 | 0.08 | 0.05 | 0.04 | 0.02 | 0.06 | 0.01 | 0.04 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.33 | 0.05 | 0.09 | 0.03 | 0.03 | 0.01 | 0.26 | 0.02 | 0.06 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.08 | 0.01 | 0.01 | 0.00 | 0.01 | 0.13 | 0.00 | 0.14 | 0.01 |
| GPR20 | ENSG00000204882 | 0.03 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.05 | 0.02 | 0.18 | 0.03 | 0.02 | 0.00 | 0.10 | 0.04 | 0.25 | 0.01 | 0.34 | 0.02 | 0.28 | 0.00 | 0.45 | 0.02 | 0.23 | 0.02 | 0.14 | 0.03 | 0.24 | 0.03 | 0.16 | 0.01 | 0.34 | 0.02 | 0.25 | 0.01 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.01 | 0.43 | 0.05 | 1.49 | 0.05 | 0.20 | 0.01 | 0.13 | 0.02 | 0.25 | 0.03 | 0.20 | 0.06 | 0.03 | 0.04 | 0.02 | 0.00 | 0.26 | 0.01 | 0.17 | 0.03 | 0.03 | 0.02 | 0.50 | 0.00 | 0.22 | 0.02 |
| SPINK9 | ENSG00000204909 | 0.30 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.00 | 0.00 | 0.02 | 0.05 | 0.05 | 0.05 | 0.01 | 0.03 | 0.01 | 0.05 | 0.03 | 0.03 | 0.03 | 0.05 | 0.01 | 0.03 | 0.03 | 0.01 | 0.02 | 0.02 | 0.08 | 0.03 | 0.09 | 0.01 | 0.22 | 0.04 | 0.00 | 0.05 | 0.01 | 0.00 | 0.03 | 0.02 | 0.14 | 0.10 | 0.02 | 0.01 | 0.02 | 0.03 | 0.09 | 0.02 | 0.08 | 0.04 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.00 | 0.00 | 0.05 | 0.01 | 0.03 | 0.00 | 0.03 | 0.03 | 0.14 |
| UQCC3 | ENSG00000204922 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.01 | 0.14 | 0.01 | 0.00 | 0.00 | 0.12 | 0.00 | 0.06 | 0.02 | 0.05 | 0.01 | 0.13 | 0.03 | 0.11 | 0.02 | 0.04 | 0.02 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.03 | 0.03 | 0.02 | 0.12 | 0.07 | 0.11 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.07 | 0.16 | 0.04 | 0.06 | 0.01 | 0.11 | 0.02 | 0.38 | 0.12 | 0.06 | 0.03 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.03 | 0.04 | 0.05 |
| CD177 | ENSG00000204936 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.07 | 0.14 | 0.03 | 0.00 | 0.00 | 0.05 | 0.07 | 0.11 | 0.05 | 0.13 | 0.08 | 0.02 | 0.02 | 0.06 | 0.07 | 0.07 | 0.02 | 0.02 | 0.02 | 0.02 | 0.03 | 0.07 | 0.03 | 0.04 | 0.03 | 0.12 | 0.01 | 0.14 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.05 | 0.20 | 0.28 | 0.17 | 0.05 | 0.05 | 0.05 | 0.09 | 0.17 | 0.11 | 0.12 | 0.00 | 0.04 | 0.01 | 0.00 | 0.05 | 0.03 | 0.01 | 0.12 | 0.03 | 0.09 | 0.00 | 0.00 | 0.02 | 0.03 |
| PRSS3P4 | ENSG00000204982 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.07 | 0.03 | 0.00 | 0.00 | 0.01 | 0.11 | 0.07 | 0.01 | 0.34 | 0.04 | 0.15 | 0.02 | 0.21 | 0.03 | 0.13 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.01 | 0.24 | 0.01 | 0.04 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.10 | 0.06 | 0.01 | 0.01 | 0.05 | 0.01 | 0.00 | 0.05 | 0.11 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.06 | 0.00 | 0.00 | 0.06 | 0.04 |
| OR5D16 | ENSG00000205029 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.01 | 0.03 | 0.13 | 0.04 | 0.00 | 0.01 | 0.04 | 0.03 | 0.04 | 0.03 | 0.08 | 0.03 | 0.11 | 0.01 | 0.16 | 0.05 | 0.01 | 0.04 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.07 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.12 | 0.06 | 0.04 | 0.02 | 0.04 | 0.03 | 0.34 | 0.03 | 0.10 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.02 | 0.05 | 0.04 |
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