Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
 HGNC Symbol  Ensembl Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
TPSB2ENSG00000197253  0.01    0.00    0.02    0.00    0.00    0.00    0.02    0.01    0.02    0.15    0.00    0.00    0.04    0.02    0.05    0.05    0.04    0.09    0.03    0.03    0.03    0.12    0.04    0.08    0.03    0.04    0.03    0.03    0.01    0.02    0.04    0.06    0.00    0.05    0.18    0.01    0.00    0.02    0.00    0.00    0.09    0.02    0.11    0.19    0.10    0.05    0.04    0.04    0.17    0.21    0.08    0.05    0.00    0.01    0.00    0.00    0.00    0.04    0.01    0.00    0.02    0.02    0.00    0.00    0.05    0.02  
IL27ENSG00000197272  0.00    0.00    0.01    0.00    0.00    0.00    0.01    0.01    0.18    0.01    0.00    0.00    0.00    0.00    0.07    0.01    0.10    0.01    0.03    0.01    0.06    0.00    0.06    0.00    0.03    0.00    0.01    0.00    0.01    0.00    0.05    0.01    0.00    0.01    0.03    0.01    0.00    0.00    0.00    0.00    0.05    0.00    0.07    0.03    0.02    0.02    0.06    0.00    0.32    0.03    0.05    0.02    0.00    0.01    0.00    0.00    0.06    0.00    0.00    0.02    0.00    0.02    0.00    0.00    0.01    0.01  
GUCA2AENSG00000197273  0.00    0.02    0.01    0.03    0.00    0.00    0.00    0.02    0.24    0.03    0.00    0.00    0.08    0.03    0.11    0.02    0.10    0.02    0.08    0.01    0.17    0.01    0.04    0.03    0.04    0.03    0.04    0.01    0.07    0.00    0.02    0.09    0.00    0.22    0.01    0.03    0.02    0.08    0.00    0.00    0.10    0.04    0.64    0.06    0.09    0.00    0.09    0.01    0.13    0.05    0.12    0.04    0.04    0.03    0.02    0.00    0.00    0.05    0.00    0.01    0.03    0.01    0.00    0.07    0.05    0.02  
OR10D3ENSG00000197309  0.00    0.01    0.00    0.05    0.00    0.02    0.02    0.07    0.03    0.10    0.00    0.00    0.11    0.06    0.06    0.09    0.05    0.10    0.04    0.14    0.05    0.15    0.04    0.08    0.01    0.01    0.01    0.03    0.01    0.02    0.00    0.10    0.00    0.19    0.02    0.04    0.00    0.05    0.00    0.00    0.02    0.22    0.19    0.17    0.04    0.31    0.04    0.07    0.05    0.17    0.01    0.24    0.00    0.24    0.03    0.00    0.13    0.02    0.06    0.01    0.01    0.02    0.00    0.07    0.01    0.26  
SLC22A5ENSG00000197375  0.28    0.01    0.03    0.02    0.00    0.00    0.02    0.04    0.03    0.04    0.00    0.00    0.00    0.05    0.00    0.07    0.00    0.06    0.01    0.06    0.03    0.06    0.03    0.10    0.01    0.05    0.02    0.04    0.01    0.04    0.09    0.04    0.09    0.01    0.28    0.02    0.00    0.03    0.01    0.00    0.03    0.04    0.13    0.19    0.02    0.05    0.01    0.02    0.15    0.04    0.03    0.06    0.01    0.00    0.00    0.10    0.04    0.02    0.01    0.03    0.02    0.02    0.00    0.03    0.01    0.09  
OR8S1ENSG00000197376  0.00    0.00    0.01    0.00    0.00    0.00    0.00    0.01    0.08    0.03    0.00    0.00    0.00    0.04    0.06    0.02    0.04    0.02    0.01    0.04    0.06    0.04    0.05    0.04    0.02    0.00    0.02    0.02    0.00    0.04    0.01    0.01    0.09    0.01    0.23    0.01    0.00    0.03    0.00    0.00    0.03    0.05    0.10    0.06    0.02    0.00    0.04    0.01    0.13    0.15    0.09    0.08    0.02    0.00    0.00    0.01    0.13    0.03    0.01    0.04    0.01    0.05    0.00    0.00    0.08    0.04  
OR6N1ENSG00000197403  0.03    0.00    0.01    0.01    0.00    0.03    0.02    0.06    0.41    0.01    0.02    0.00    0.11    0.00    0.26    0.00    0.25    0.00    0.06    0.00    0.24    0.00    0.11    0.00    0.03    0.00    0.11    0.00    0.07    0.00    0.28    0.00    0.35    0.01    0.16    0.00    0.04    0.00    0.00    0.00    0.23    0.01    0.37    0.02    0.15    0.00    0.13    0.00    0.28    0.00    0.37    0.01    0.10    0.00    0.00    0.00    0.24    0.00    0.01    0.00    0.02    0.01    0.00    0.00    0.15    0.02  
C5AR1ENSG00000197405  0.00    0.00    0.00    0.02    0.00    0.00    0.01    0.05    0.06    0.04    0.00    0.02    0.00    0.09    0.02    0.08    0.04    0.11    0.02    0.02    0.06    0.04    0.04    0.03    0.01    0.03    0.03    0.04    0.03    0.05    0.03    0.04    0.00    0.10    0.13    0.03    0.00    0.03    0.00    0.00    0.04    0.06    0.03    0.33    0.05    0.08    0.03    0.06    0.06    0.19    0.04    0.21    0.00    0.04    0.01    0.00    0.07    0.03    0.00    0.13    0.01    0.13    0.00    0.00    0.02    0.03  
DIO3ENSG00000197406  0.00    0.02    0.01    0.01    0.00    0.04    0.02    0.03    0.08    0.06    0.00    0.00    0.00    0.08    0.05    0.06    0.19    0.03    0.05    0.05    0.07    0.05    0.03    0.07    0.00    0.03    0.02    0.04    0.01    0.02    0.00    0.10    0.00    0.31    0.05    0.00    0.01    0.04    0.00    0.00    0.05    0.07    0.21    0.15    0.06    0.10    0.06    0.01    0.11    0.02    0.17    0.05    0.03    0.02    0.00    0.00    0.02    0.00    0.00    0.08    0.01    0.06    0.03    0.01    0.01    0.06  
CYP2B6ENSG00000197408  0.00    0.00    0.00    0.02    0.00    0.02    0.01    0.04    0.17    0.02    0.00    0.00    0.08    0.02    0.10    0.03    0.25    0.08    0.03    0.02    0.04    0.05    0.07    0.02    0.03    0.01    0.01    0.01    0.13    0.02    0.08    0.02    0.12    0.01    0.05    0.04    0.00    0.02    0.00    0.00    0.07    0.04    0.27    0.25    0.08    0.04    0.08    0.04    0.45    0.14    0.23    0.12    0.00    0.03    0.01    0.00    0.05    0.00    0.02    0.07    0.02    0.08    0.00    0.00    0.02    0.02  
HIST1H3DENSG00000197409  0.00    0.01    0.00    0.01    0.00    0.00    0.01    0.02    0.22    0.03    0.00    0.01    0.02    0.05    0.08    0.02    0.07    0.06    0.02    0.05    0.10    0.12    0.05    0.06    0.03    0.03    0.04    0.04    0.03    0.07    0.11    0.02    0.06    0.08    0.04    0.03    0.00    0.00    0.00    0.00    0.12    0.03    0.36    0.06    0.10    0.03    0.05    0.02    0.20    0.07    0.03    0.07    0.01    0.02    0.01    0.00    0.00    0.04    0.01    0.02    0.01    0.00    0.11    0.00    0.14    0.01  
OR51D1ENSG00000197428  0.00    0.00    0.00    0.00    0.00    0.03    0.00    0.02    0.01    0.10    0.00    0.00    0.03    0.05    0.02    0.06    0.02    0.14    0.01    0.07    0.02    0.10    0.03    0.05    0.02    0.01    0.01    0.02    0.00    0.05    0.04    0.03    0.03    0.01    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.11    0.02    0.44    0.01    0.05    0.02    0.06    0.03    0.09    0.05    0.14    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.10    0.01    0.05    0.00    0.00    0.01    0.03  
OR13G1ENSG00000197437  0.01    0.02    0.01    0.01    0.00    0.01    0.02    0.04    0.14    0.04    0.02    0.02    0.08    0.05    0.13    0.01    0.17    0.03    0.10    0.02    0.27    0.04    0.13    0.01    0.04    0.02    0.08    0.01    0.02    0.01    0.20    0.02    0.23    0.02    0.10    0.07    0.00    0.04    0.00    0.00    0.29    0.02    0.48    0.12    0.13    0.01    0.12    0.02    0.32    0.00    0.09    0.24    0.06    0.02    0.01    0.00    0.03    0.18    0.02    0.04    0.02    0.04    0.15    0.03    0.24    0.02  
CYP2F1ENSG00000197446  0.00    0.00    0.00    0.02    0.00    0.02    0.01    0.04    0.14    0.03    0.00    0.00    0.08    0.02    0.09    0.03    0.21    0.07    0.03    0.02    0.03    0.05    0.07    0.02    0.03    0.01    0.01    0.01    0.07    0.02    0.05    0.02    0.12    0.01    0.07    0.04    0.00    0.02    0.00    0.00    0.06    0.04    0.20    0.25    0.08    0.04    0.06    0.04    0.16    0.17    0.24    0.11    0.00    0.03    0.01    0.00    0.05    0.00    0.02    0.07    0.01    0.08    0.00    0.00    0.02    0.02  
GSTK1ENSG00000197448  0.02    0.01    0.05    0.00    0.05    0.02    0.02    0.03    0.05    0.03    0.00    0.01    0.04    0.03    0.07    0.02    0.08    0.06    0.02    0.15    0.03    0.20    0.02    0.10    0.03    0.00    0.02    0.03    0.02    0.04    0.04    0.05    0.00    0.11    0.06    0.09    0.00    0.02    0.00    0.00    0.08    0.05    0.54    0.04    0.03    0.09    0.05    0.05    0.10    0.14    0.13    0.11    0.02    0.04    0.00    0.05    0.02    0.09    0.11    0.01    0.04    0.02    0.00    0.03    0.21    0.02  
OR2L5ENSG00000197454  0.01    0.02    0.01    0.01    0.00    0.01    0.02    0.04    0.14    0.04    0.02    0.02    0.08    0.05    0.13    0.01    0.17    0.03    0.10    0.02    0.27    0.04    0.13    0.01    0.04    0.02    0.08    0.01    0.02    0.01    0.20    0.02    0.23    0.02    0.10    0.07    0.00    0.04    0.00    0.00    0.29    0.02    0.48    0.12    0.13    0.01    0.12    0.02    0.32    0.00    0.09    0.24    0.06    0.02    0.01    0.00    0.03    0.18    0.02    0.04    0.02    0.04    0.15    0.03    0.24    0.02  
GYPEENSG00000197465  0.03    0.02    0.00    0.01    0.06    0.00    0.02    0.01    0.11    0.08    0.00    0.00    0.00    0.01    0.03    0.03    0.05    0.11    0.03    0.04    0.14    0.04    0.07    0.04    0.01    0.02    0.02    0.02    0.00    0.02    0.06    0.05    0.00    0.03    0.08    0.05    0.00    0.03    0.00    0.00    0.06    0.03    0.11    0.15    0.03    0.05    0.03    0.02    0.04    0.04    0.11    0.08    0.00    0.01    0.00    0.00    0.03    0.03    0.01    0.07    0.00    0.02    0.00    0.00    0.03    0.03  
COL13A1ENSG00000197467  0.00    0.01    0.00    0.01    0.03    0.00    0.01    0.02    0.03    0.03    0.00    0.00    0.01    0.00    0.04    0.03    0.07    0.04    0.03    0.02    0.04    0.05    0.09    0.02    0.03    0.03    0.04    0.05    0.01    0.00    0.04    0.02    0.25    0.04    0.04    0.00    0.00    0.00    0.00    0.01    0.08    0.03    0.12    0.11    0.00    0.01    0.04    0.03    0.19    0.05    0.02    0.10    0.01    0.00    0.00    0.00    0.00    0.00    0.01    0.00    0.00    0.05    0.00    0.00    0.00    0.01  
ADAM3AENSG00000197475  0.00    0.01    0.00    0.00    0.00    0.00    0.06    0.07    0.37    0.06    0.00    0.00    0.02    0.00    0.19    0.04    0.61    0.03    0.21    0.02    0.27    0.04    0.05    0.04    0.15    0.03    0.08    0.06    0.05    0.00    0.07    0.05    0.03    0.01    0.09    0.00    0.01    0.00    0.00    0.00    0.54    0.04    0.22    0.09    0.08    0.03    0.12    0.03    0.61    0.14    0.17    0.04    0.01    0.00    0.01    0.00    0.00    0.02    0.01    0.00    0.00    0.01    0.00    0.01    0.04    0.04  
GALPENSG00000197487  0.01    0.00    0.01    0.02    0.00    0.00    0.04    0.00    0.20    0.03    0.00    0.00    0.01    0.04    0.04    0.06    0.12    0.08    0.06    0.03    0.13    0.03    0.14    0.02    0.03    0.03    0.01    0.04    0.04    0.04    0.07    0.02    0.02    0.07    0.21    0.01    0.00    0.03    0.00    0.00    0.18    0.04    0.18    0.28    0.12    0.06    0.07    0.05    0.25    0.10    0.04    0.20    0.00    0.06    0.01    0.00    0.28    0.03    0.00    0.18    0.04    0.12    0.00    0.00    0.04    0.05  

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