Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
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IFNA2ENSG00000188379  0.00    0.02    0.00    0.08    0.00    0.06    0.00    0.05    0.05    0.48    0.00    0.04    0.00    0.83    0.03    0.30    0.04    0.37    0.06    0.19    0.02    0.31    0.01    0.21    0.02    0.02    0.01    0.02    0.03    0.43    0.01    0.11    0.00    0.16    0.00    0.13    0.00    0.01    0.00    0.00    0.07    0.09    0.07    0.20    0.05    0.05    0.05    0.02    0.04    0.05    0.05    0.26    0.02    0.01    0.00    0.00    0.00    0.09    0.00    0.26    0.01    1.83    0.00    0.00    0.01    0.35  
PDCD1ENSG00000188389  0.01    0.08    0.04    0.05    0.00    0.10    0.02    0.04    0.00    0.32    0.00    0.01    0.00    0.07    0.05    0.05    0.03    0.20    0.02    0.18    0.04    0.18    0.03    0.10    0.02    0.03    0.04    0.04    0.04    0.04    0.03    0.09    0.05    0.01    0.05    0.11    0.00    0.01    0.00    0.01    0.03    0.12    0.22    0.30    0.02    0.38    0.03    0.08    0.13    0.09    0.05    0.53    0.03    0.05    0.00    0.00    0.00    0.00    0.00    0.15    0.00    0.04    0.04    0.05    0.01    0.14  
GPR21ENSG00000188394  0.00    0.00    0.01    0.00    0.00    0.00    0.04    0.01    0.03    0.06    0.00    0.01    0.01    0.02    0.03    0.03    0.05    0.02    0.06    0.03    0.10    0.01    0.08    0.01    0.01    0.01    0.04    0.03    0.00    0.01    0.03    0.04    0.06    0.04    0.04    0.04    0.00    0.00    0.00    0.00    0.06    0.03    0.12    0.15    0.02    0.01    0.02    0.04    0.00    0.16    0.09    0.04    0.02    0.02    0.00    0.00    0.05    0.00    0.01    0.01    0.03    0.02    0.00    0.00    0.02    0.02  
SELLENSG00000188404  0.03    0.00    0.01    0.01    0.00    0.03    0.01    0.05    0.45    0.01    0.02    0.02    0.10    0.03    0.14    0.01    0.24    0.01    0.04    0.00    0.21    0.01    0.11    0.01    0.03    0.00    0.11    0.00    0.06    0.00    0.23    0.00    0.22    0.05    0.00    0.04    0.04    0.00    0.00    0.00    0.20    0.02    0.33    0.02    0.11    0.00    0.10    0.00    0.29    0.00    0.44    0.03    0.10    0.00    0.00    0.00    0.36    0.04    0.01    0.00    0.01    0.01    0.00    0.00    0.15    0.01  
SERPINA5ENSG00000188488  0.00    0.02    0.01    0.00    0.00    0.04    0.02    0.04    0.04    0.06    0.00    0.00    0.00    0.05    0.03    0.06    0.12    0.02    0.05    0.04    0.07    0.06    0.03    0.05    0.00    0.03    0.01    0.02    0.01    0.02    0.02    0.09    0.00    0.31    0.05    0.00    0.01    0.01    0.00    0.00    0.04    0.09    0.20    0.17    0.07    0.10    0.04    0.03    0.06    0.02    0.09    0.10    0.03    0.01    0.00    0.00    0.03    0.00    0.00    0.10    0.02    0.06    0.03    0.01    0.01    0.06  
LCTLENSG00000188501  0.01    0.00    0.00    0.00    0.05    0.00    0.01    0.02    0.02    0.02    0.00    0.00    0.09    0.00    0.03    0.02    0.04    0.03    0.02    0.02    0.05    0.02    0.05    0.03    0.01    0.02    0.01    0.03    0.03    0.02    0.04    0.01    0.00    0.01    0.04    0.01    0.00    0.00    0.00    0.00    0.06    0.05    0.13    0.10    0.06    0.01    0.01    0.04    0.00    0.17    0.11    0.03    0.01    0.01    0.00    0.00    0.06    0.02    0.01    0.00    0.01    0.01    0.00    0.00    0.08    0.00  
KRTDAPENSG00000188508  0.00    0.00    0.03    0.00    0.00    0.02    0.01    0.01    0.19    0.02    0.00    0.00    0.07    0.02    0.25    0.00    0.43    0.03    0.08    0.01    0.22    0.03    0.08    0.04    0.05    0.00    0.04    0.01    0.11    0.00    0.05    0.02    0.13    0.01    0.00    0.02    0.00    0.03    0.00    0.00    0.14    0.02    0.63    0.05    0.22    0.01    0.18    0.02    1.50    0.01    0.29    0.05    0.01    0.02    0.00    0.01    0.08    0.00    0.02    0.01    0.03    0.03    0.00    0.00    0.05    0.01  
DUSP28ENSG00000188542  0.02    0.08    0.04    0.05    0.00    0.10    0.01    0.04    0.00    0.33    0.00    0.02    0.00    0.07    0.04    0.05    0.03    0.20    0.02    0.18    0.03    0.17    0.03    0.10    0.02    0.04    0.04    0.04    0.04    0.04    0.03    0.09    0.10    0.01    0.05    0.10    0.00    0.01    0.00    0.01    0.03    0.11    0.20    0.29    0.02    0.38    0.03    0.07    0.17    0.09    0.05    0.48    0.03    0.06    0.00    0.00    0.00    0.02    0.00    0.14    0.00    0.04    0.01    0.08    0.01    0.16  
OR2G6ENSG00000188558  0.01    0.02    0.01    0.01    0.00    0.01    0.02    0.04    0.14    0.04    0.02    0.02    0.08    0.05    0.13    0.01    0.17    0.03    0.10    0.02    0.27    0.04    0.13    0.01    0.04    0.02    0.08    0.01    0.02    0.01    0.20    0.02    0.23    0.02    0.10    0.07    0.00    0.04    0.00    0.00    0.29    0.02    0.48    0.12    0.13    0.01    0.12    0.02    0.32    0.00    0.09    0.24    0.06    0.02    0.01    0.00    0.03    0.18    0.02    0.04    0.02    0.04    0.15    0.03    0.24    0.02  
NDOR1ENSG00000188566  0.01    0.01    0.01    0.01    0.00    0.00    0.04    0.01    0.06    0.02    0.00    0.01    0.00    0.02    0.07    0.03    0.08    0.02    0.09    0.05    0.23    0.01    0.17    0.02    0.03    0.01    0.08    0.05    0.02    0.00    0.06    0.04    0.11    0.01    0.13    0.03    0.01    0.01    0.00    0.00    0.07    0.06    0.22    0.21    0.07    0.03    0.09    0.04    0.26    0.14    0.08    0.17    0.03    0.03    0.01    0.00    0.05    0.00    0.03    0.01    0.05    0.01    0.00    0.00    0.04    0.03  
RNASE9ENSG00000188655  0.00    0.00    0.00    0.03    0.00    0.00    0.00    0.02    0.09    0.05    0.00    0.00    0.00    0.05    0.17    0.03    0.17    0.07    0.08    0.05    0.13    0.06    0.11    0.04    0.03    0.02    0.01    0.08    0.01    0.04    0.09    0.00    0.00    0.02    0.27    0.03    0.01    0.02    0.00    0.00    0.09    0.03    0.40    0.10    0.07    0.02    0.08    0.03    0.15    0.08    0.18    0.08    0.02    0.01    0.00    0.01    0.01    0.00    0.02    0.02    0.01    0.10    0.00    0.00    0.03    0.02  
OR56A5ENSG00000188691  0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.01    0.00    0.10    0.00    0.00    0.02    0.08    0.01    0.06    0.02    0.13    0.01    0.06    0.05    0.09    0.02    0.04    0.02    0.01    0.01    0.02    0.00    0.05    0.03    0.01    0.03    0.01    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.10    0.01    0.42    0.01    0.05    0.02    0.07    0.03    0.09    0.04    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.09    0.00    0.06    0.00    0.00    0.01    0.03  
QRFPENSG00000188710  0.00    0.00    0.01    0.01    0.00    0.00    0.02    0.01    0.02    0.02    0.00    0.01    0.00    0.02    0.04    0.03    0.06    0.02    0.08    0.02    0.11    0.03    0.10    0.01    0.02    0.01    0.04    0.04    0.00    0.00    0.05    0.03    0.06    0.01    0.14    0.04    0.00    0.00    0.00    0.00    0.04    0.05    0.09    0.24    0.07    0.01    0.04    0.05    0.06    0.11    0.05    0.10    0.03    0.03    0.01    0.00    0.05    0.00    0.02    0.01    0.03    0.02    0.00    0.03    0.02    0.03  
DUPD1ENSG00000188716  0.00    0.01    0.01    0.01    0.03    0.00    0.01    0.07    0.11    0.02    0.00    0.00    0.01    0.00    0.04    0.02    0.08    0.04    0.04    0.03    0.08    0.03    0.19    0.05    0.04    0.02    0.12    0.04    0.06    0.00    0.03    0.03    0.25    0.01    0.00    0.00    0.00    0.00    0.00    0.01    0.17    0.03    0.32    0.10    0.01    0.01    0.26    0.03    0.65    0.00    0.04    0.13    0.01    0.00    0.00    0.00    0.00    0.00    0.00    0.00    0.01    0.03    0.00    0.00    0.01    0.01  
OSTNENSG00000188729  0.05    0.00    0.03    0.01    0.00    0.01    0.03    0.04    0.15    0.01    0.00    0.00    0.00    0.07    0.13    0.05    1.40    0.01    0.58    0.00    0.74    0.02    0.22    0.02    0.05    0.01    0.06    0.02    0.03    0.00    0.11    0.04    0.12    0.03    0.10    0.00    0.00    0.10    0.00    0.00    0.19    0.02    0.96    0.08    0.63    0.00    0.34    0.01    0.79    0.11    0.12    0.09    0.23    0.00    0.00    0.00    0.07    0.04    0.02    0.04    0.07    0.09    0.00    0.00    0.03    0.04  
FZD9ENSG00000188763  0.01    0.00    0.03    0.00    0.00    0.00    0.03    0.00    0.04    0.02    0.00    0.00    0.02    0.00    0.02    0.02    0.10    0.02    0.04    0.03    0.17    0.03    0.09    0.02    0.01    0.00    0.01    0.00    0.02    0.00    0.08    0.01    0.00    0.01    0.15    0.00    0.00    0.02    0.00    0.00    0.09    0.02    0.16    0.06    0.04    0.01    0.05    0.02    0.08    0.00    0.07    0.03    0.12    0.00    0.00    0.00    0.10    0.00    0.01    0.01    0.05    0.00    0.00    0.00    0.06    0.02  
ADRB3ENSG00000188778  0.00    0.01    0.03    0.00    0.00    0.00    0.07    0.06    0.40    0.05    0.00    0.00    0.04    0.00    0.17    0.04    0.87    0.03    0.27    0.03    0.37    0.06    0.08    0.03    0.11    0.04    0.08    0.04    0.10    0.00    0.05    0.06    0.02    0.02    0.16    0.00    0.02    0.00    0.00    0.00    0.76    0.04    0.21    0.09    0.05    0.02    0.12    0.05    0.52    0.11    0.16    0.04    0.01    0.00    0.01    0.00    0.00    0.02    0.01    0.00    0.00    0.02    0.00    0.01    0.04    0.03  
CATSPER4ENSG00000188782  0.00    0.06    0.00    0.08    0.00    0.00    0.01    0.02    0.06    0.10    0.00    0.01    0.05    0.19    0.04    0.07    0.02    0.12    0.02    0.07    0.01    0.14    0.02    0.15    0.00    0.17    0.00    0.22    0.01    0.10    0.01    0.21    0.00    1.06    0.01    0.10    0.01    0.07    0.00    0.00    0.02    0.18    0.09    0.45    0.04    0.07    0.02    0.13    0.11    0.18    0.14    0.09    0.04    0.06    0.02    0.00    0.00    0.07    0.00    0.02    0.02    0.08    0.00    0.12    0.05    0.06  
PLA2G2EENSG00000188784  0.00    0.06    0.00    0.08    0.00    0.00    0.01    0.03    0.07    0.09    0.00    0.01    0.04    0.25    0.05    0.07    0.03    0.11    0.03    0.08    0.05    0.09    0.07    0.10    0.00    0.16    0.00    0.22    0.01    0.07    0.02    0.22    0.00    1.11    0.01    0.05    0.01    0.10    0.00    0.00    0.02    0.20    0.13    0.43    0.05    0.08    0.05    0.13    0.03    0.15    0.18    0.13    0.05    0.06    0.02    0.01    0.00    0.03    0.00    0.02    0.03    0.10    0.00    0.12    0.05    0.09  
CNR2ENSG00000188822  0.00    0.06    0.00    0.08    0.00    0.00    0.00    0.03    0.07    0.08    0.00    0.03    0.04    0.23    0.04    0.06    0.04    0.11    0.02    0.07    0.05    0.10    0.07    0.10    0.00    0.16    0.00    0.21    0.01    0.08    0.02    0.21    0.00    1.06    0.01    0.04    0.01    0.09    0.00    0.00    0.01    0.18    0.14    0.43    0.04    0.08    0.03    0.12    0.18    0.18    0.15    0.09    0.04    0.06    0.02    0.00    0.00    0.11    0.00    0.03    0.02    0.10    0.00    0.09    0.07    0.08  

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