Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
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OR52E8ENSG00000183269  0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.02    0.00    0.10    0.00    0.00    0.02    0.08    0.01    0.06    0.01    0.14    0.01    0.06    0.05    0.09    0.02    0.04    0.02    0.01    0.01    0.03    0.00    0.05    0.03    0.01    0.03    0.01    0.01    0.07    0.03    0.09    0.00    0.00    0.02    0.10    0.01    0.43    0.01    0.06    0.02    0.07    0.03    0.09    0.06    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.10    0.00    0.06    0.00    0.00    0.01    0.03  
OR5P2ENSG00000183303  0.01    0.00    0.00    0.01    0.00    0.03    0.01    0.01    0.00    0.10    0.03    0.00    0.02    0.08    0.01    0.06    0.01    0.14    0.01    0.06    0.04    0.08    0.02    0.04    0.01    0.01    0.01    0.02    0.00    0.05    0.03    0.02    0.03    0.01    0.01    0.04    0.02    0.07    0.00    0.00    0.04    0.09    0.01    0.41    0.01    0.07    0.02    0.07    0.06    0.05    0.08    0.12    0.02    0.01    0.00    0.00    0.02    0.00    0.01    0.09    0.00    0.04    0.00    0.00    0.02    0.02  
OR2T34ENSG00000183310  0.01    0.02    0.01    0.01    0.00    0.01    0.02    0.04    0.14    0.04    0.02    0.02    0.08    0.05    0.13    0.01    0.17    0.03    0.10    0.02    0.27    0.04    0.13    0.01    0.04    0.02    0.08    0.01    0.02    0.01    0.20    0.02    0.23    0.02    0.10    0.07    0.00    0.04    0.00    0.00    0.29    0.02    0.48    0.12    0.13    0.01    0.12    0.02    0.32    0.00    0.09    0.24    0.06    0.02    0.01    0.00    0.03    0.18    0.02    0.04    0.02    0.04    0.15    0.03    0.24    0.02  
OR52L1ENSG00000183313  0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.01    0.00    0.10    0.00    0.00    0.02    0.08    0.01    0.06    0.02    0.13    0.01    0.06    0.05    0.09    0.02    0.04    0.02    0.01    0.01    0.02    0.00    0.05    0.03    0.01    0.03    0.01    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.10    0.01    0.42    0.01    0.05    0.02    0.07    0.03    0.09    0.04    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.09    0.01    0.06    0.00    0.00    0.01    0.03  
KIAA2026ENSG00000183354  0.00    0.00    0.00    0.02    0.00    0.00    0.00    0.05    0.17    0.12    0.01    0.01    0.04    0.05    0.05    0.12    0.16    0.10    0.25    0.06    0.17    0.15    0.14    0.11    0.01    0.03    0.04    0.05    0.00    0.08    0.06    0.03    0.03    0.01    0.12    0.08    0.01    0.02    0.00    0.00    0.10    0.06    0.17    0.20    0.21    0.04    0.08    0.03    0.02    0.12    0.24    0.12    0.01    0.09    0.00    0.00    0.04    0.02    0.00    0.09    0.01    0.20    0.00    0.00    0.05    0.11  
OVCH2ENSG00000183378  0.01    0.00    0.00    0.01    0.00    0.03    0.01    0.02    0.00    0.10    0.03    0.00    0.02    0.08    0.01    0.06    0.01    0.13    0.01    0.06    0.05    0.08    0.02    0.04    0.01    0.01    0.01    0.02    0.00    0.05    0.03    0.02    0.03    0.01    0.01    0.04    0.02    0.07    0.00    0.00    0.04    0.09    0.01    0.40    0.01    0.07    0.02    0.07    0.10    0.05    0.08    0.12    0.02    0.01    0.00    0.00    0.02    0.00    0.01    0.09    0.00    0.04    0.00    0.00    0.02    0.02  
OR56A4ENSG00000183389  0.00    0.00    0.00    0.01    0.00    0.03    0.01    0.01    0.00    0.10    0.00    0.00    0.02    0.08    0.01    0.06    0.02    0.14    0.01    0.06    0.05    0.09    0.02    0.04    0.02    0.01    0.01    0.02    0.00    0.05    0.03    0.02    0.03    0.01    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.10    0.01    0.42    0.01    0.06    0.02    0.07    0.03    0.09    0.04    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.09    0.00    0.06    0.00    0.00    0.01    0.03  
PMCHENSG00000183395  0.01    0.01    0.02    0.00    0.06    0.02    0.04    0.02    0.08    0.03    0.00    0.00    0.02    0.02    0.02    0.05    0.03    0.04    0.02    0.03    0.03    0.07    0.04    0.04    0.01    0.01    0.01    0.03    0.00    0.07    0.03    0.04    0.00    0.22    0.00    0.04    0.00    0.03    0.00    0.00    0.03    0.07    0.07    0.21    0.01    0.01    0.02    0.03    0.02    0.11    0.28    0.04    0.00    0.01    0.00    0.00    0.08    0.02    0.01    0.02    0.01    0.01    0.02    0.00    0.01    0.09  
RIPK4ENSG00000183421  0.00    0.00    0.01    0.00    0.00    0.00    0.01    0.04    0.05    0.04    0.00    0.03    0.00    0.00    0.02    0.02    0.03    0.08    0.01    0.08    0.02    0.09    0.03    0.09    0.01    0.01    0.01    0.08    0.01    0.01    0.02    0.02    0.07    0.03    0.01    0.05    0.01    0.00    0.00    0.00    0.08    0.02    0.11    0.17    0.07    0.03    0.04    0.01    0.09    0.03    0.06    0.07    0.04    0.00    0.12    0.00    0.00    0.00    0.00    0.00    0.00    0.02    0.03    0.00    0.01    0.02  
GPR132ENSG00000183484  0.00    0.02    0.01    0.01    0.01    0.04    0.02    0.03    0.08    0.07    0.00    0.00    0.00    0.07    0.07    0.07    0.21    0.04    0.09    0.05    0.13    0.07    0.04    0.07    0.01    0.03    0.03    0.03    0.02    0.02    0.02    0.13    0.00    0.31    0.15    0.00    0.01    0.03    0.00    0.00    0.08    0.07    0.37    0.16    0.08    0.09    0.09    0.02    0.19    0.05    0.18    0.06    0.03    0.01    0.00    0.00    0.04    0.03    0.01    0.07    0.02    0.05    0.03    0.03    0.02    0.06  
SETD3ENSG00000183576  0.00    0.02    0.01    0.02    0.00    0.04    0.01    0.04    0.07    0.06    0.00    0.00    0.00    0.09    0.04    0.06    0.19    0.02    0.07    0.05    0.08    0.05    0.03    0.07    0.00    0.03    0.01    0.02    0.01    0.02    0.00    0.11    0.00    0.31    0.05    0.00    0.01    0.02    0.00    0.00    0.06    0.07    0.21    0.17    0.06    0.10    0.03    0.02    0.08    0.02    0.08    0.06    0.03    0.01    0.00    0.00    0.00    0.03    0.00    0.08    0.02    0.07    0.03    0.01    0.01    0.06  
GKN2ENSG00000183607  0.00    0.00    0.00    0.01    0.00    0.00    0.00    0.04    0.11    0.00    0.00    0.00    0.00    0.03    0.03    0.01    0.18    0.00    0.05    0.00    0.07    0.00    0.03    0.01    0.00    0.01    0.01    0.01    0.00    0.01    0.01    0.03    0.06    0.02    0.03    0.04    0.00    0.01    0.00    0.00    0.05    0.01    0.15    0.04    0.03    0.01    0.05    0.01    0.13    0.00    0.05    0.04    0.03    0.05    0.00    0.00    0.04    0.02    0.00    0.01    0.00    0.02    0.00    0.00    0.01    0.01  
CCR3ENSG00000183625  0.00    0.18    0.00    0.02    0.08    0.00    0.00    0.02    0.08    0.10    0.00    0.03    0.00    0.52    0.01    0.06    0.01    0.08    0.00    0.05    0.01    0.08    0.01    0.09    0.00    0.04    0.03    0.06    0.00    0.04    0.03    0.03    0.00    0.24    0.01    0.02    0.01    0.02    0.00    0.00    0.01    0.15    0.08    0.18    0.01    0.05    0.02    0.05    0.03    0.18    0.04    0.13    0.01    0.04    0.00    0.01    0.00    0.10    0.00    0.05    0.00    0.04    0.00    0.03    0.02    0.05  
DGCR6ENSG00000183628  0.00    0.00    0.00    0.01    0.00    0.00    0.00    0.05    0.17    0.06    0.03    0.01    0.08    0.05    0.07    0.03    0.17    0.07    0.10    0.03    0.08    0.07    0.05    0.04    0.02    0.01    0.06    0.03    0.00    0.02    0.02    0.03    0.08    0.10    0.10    0.14    0.01    0.01    0.02    0.00    0.06    0.05    0.19    0.07    0.05    0.01    0.06    0.06    0.42    0.04    0.14    0.07    0.13    0.01    0.01    0.00    0.00    0.00    0.01    0.02    0.01    0.03    0.00    0.00    0.13    0.03  
KLHL25ENSG00000183655  0.00    0.00    0.00    0.00    0.02    0.02    0.02    0.02    0.09    0.02    0.03    0.00    0.10    0.00    0.04    0.01    0.16    0.01    0.04    0.03    0.16    0.02    0.11    0.02    0.04    0.00    0.03    0.00    0.05    0.01    0.05    0.04    0.05    0.01    0.03    0.00    0.00    0.00    0.00    0.00    0.14    0.02    0.27    0.08    0.16    0.00    0.03    0.03    0.27    0.05    0.13    0.04    0.00    0.00    0.00    0.00    0.06    0.00    0.01    0.01    0.01    0.02    0.00    0.00    0.17    0.01  
FAM19A1ENSG00000183662  0.00    0.04    0.00    0.02    0.00    0.02    0.00    0.05    0.05    0.18    0.00    0.04    0.02    0.20    0.03    0.05    0.01    0.15    0.01    0.08    0.04    0.16    0.04    0.05    0.01    0.01    0.03    0.04    0.00    0.03    0.02    0.07    0.00    0.20    0.08    0.01    0.00    0.05    0.00    0.00    0.01    0.15    0.12    0.14    0.00    0.13    0.03    0.08    0.30    0.26    0.05    0.12    0.08    0.00    0.00    0.03    0.02    0.00    0.00    0.03    0.00    0.03    0.00    0.00    0.18    0.01  
GPR1ENSG00000183671  0.02    0.03    0.04    0.02    0.00    0.03    0.02    0.01    0.02    0.16    0.00    0.00    0.00    0.06    0.04    0.02    0.09    0.12    0.03    0.16    0.09    0.09    0.07    0.03    0.02    0.01    0.03    0.01    0.07    0.02    0.05    0.01    0.00    0.01    0.03    0.00    0.00    0.00    0.00    0.00    0.06    0.04    0.23    0.11    0.03    0.28    0.04    0.03    0.06    0.05    0.06    0.12    0.06    0.01    0.00    0.00    0.00    0.04    0.00    0.01    0.00    0.00    0.02    0.02    0.02    0.03  
BMP8AENSG00000183682  0.01    0.02    0.01    0.03    0.00    0.00    0.01    0.01    0.32    0.03    0.00    0.00    0.11    0.03    0.13    0.02    0.16    0.02    0.09    0.02    0.29    0.02    0.07    0.03    0.04    0.02    0.01    0.03    0.04    0.01    0.02    0.10    0.00    0.31    0.02    0.03    0.03    0.07    0.00    0.00    0.08    0.04    0.76    0.06    0.07    0.01    0.11    0.02    0.30    0.05    0.12    0.03    0.06    0.03    0.02    0.00    0.00    0.03    0.00    0.01    0.04    0.01    0.00    0.10    0.05    0.03  
NOGENSG00000183691  0.01    0.00    0.05    0.00    0.00    0.00    0.03    0.03    0.19    0.02    0.01    0.00    0.12    0.00    0.09    0.01    0.13    0.02    0.05    0.02    0.09    0.03    0.05    0.02    0.02    0.01    0.06    0.04    0.04    0.12    0.11    0.01    0.12    0.01    0.08    0.03    0.02    0.00    0.00    0.00    0.44    0.02    0.16    0.03    0.10    0.02    0.07    0.04    0.14    0.02    0.13    0.02    0.01    0.00    0.00    0.00    0.00    0.02    0.05    0.01    0.03    0.00    0.14    0.00    0.19    0.02  
MRGPRX2ENSG00000183695  0.00    0.00    0.00    0.00    0.02    0.04    0.01    0.01    0.02    0.07    0.00    0.00    0.02    0.03    0.02    0.03    0.07    0.06    0.01    0.04    0.05    0.03    0.02    0.02    0.02    0.00    0.01    0.01    0.00    0.02    0.04    0.01    0.00    0.03    0.00    0.02    0.06    0.04    0.00    0.00    0.07    0.04    0.04    0.23    0.01    0.04    0.04    0.04    0.01    0.04    0.08    0.07    0.01    0.00    0.00    0.00    0.00    0.00    0.02    0.03    0.00    0.01    0.00    0.00    0.02    0.01  

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