Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
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OR5T2ENSG00000181718  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR2Z1ENSG00000181733  0.00    0.00    0.00    0.01    0.00    0.00    0.00    0.01    0.06    0.06    0.00    0.01    0.05    0.03    0.02    0.05    0.07    0.07    0.04    0.06    0.01    0.10    0.04    0.08    0.01    0.01    0.00    0.06    0.02    0.03    0.01    0.11    0.00    0.01    0.09    0.03    0.01    0.00    0.00    0.01    0.08    0.06    0.36    0.33    0.09    0.10    0.12    0.15    0.13    0.41    0.20    0.00    0.02    0.00    0.02    0.00    0.00    0.03    0.00    0.00    0.04    0.01    0.02    0.02    0.03    0.01  
OR8K5ENSG00000181752  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR8H3ENSG00000181761  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR8H2ENSG00000181767  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
GPR3ENSG00000181773  0.00    0.06    0.00    0.08    0.00    0.00    0.01    0.03    0.04    0.09    0.00    0.01    0.05    0.19    0.04    0.06    0.03    0.10    0.02    0.07    0.04    0.13    0.02    0.13    0.00    0.17    0.00    0.22    0.00    0.10    0.00    0.21    0.00    1.06    0.04    0.04    0.01    0.09    0.00    0.00    0.02    0.18    0.11    0.44    0.07    0.08    0.04    0.12    0.03    0.18    0.12    0.08    0.04    0.04    0.02    0.00    0.00    0.07    0.00    0.02    0.02    0.07    0.00    0.07    0.07    0.06  
OR5AS1ENSG00000181785  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR6S1ENSG00000181803  0.00    0.00    0.00    0.03    0.00    0.00    0.00    0.02    0.09    0.05    0.00    0.00    0.00    0.05    0.16    0.03    0.17    0.07    0.08    0.05    0.11    0.07    0.10    0.04    0.03    0.03    0.01    0.08    0.01    0.04    0.09    0.00    0.00    0.02    0.27    0.03    0.01    0.02    0.00    0.00    0.09    0.03    0.41    0.10    0.07    0.02    0.08    0.03    0.15    0.08    0.18    0.08    0.02    0.01    0.00    0.01    0.01    0.00    0.02    0.02    0.01    0.10    0.00    0.00    0.03    0.02  
SLC35C1ENSG00000181830  0.01    0.00    0.00    0.00    0.05    0.00    0.00    0.08    0.04    0.05    0.00    0.01    0.00    0.01    0.05    0.02    0.12    0.03    0.11    0.01    0.17    0.05    0.13    0.01    0.01    0.00    0.01    0.00    0.01    0.03    0.03    0.00    0.00    0.07    0.06    0.01    0.00    0.03    0.00    0.00    0.07    0.03    0.14    0.06    0.07    0.02    0.05    0.02    0.06    0.03    0.11    0.07    0.00    0.02    0.00    0.00    0.00    0.00    0.00    0.02    0.01    0.05    0.00    0.02    0.02    0.05  
SLC2A4ENSG00000181856  0.00    0.01    0.00    0.01    0.00    0.00    0.00    0.24    0.05    0.03    0.00    0.01    0.00    0.03    0.01    0.05    0.01    0.03    0.02    0.03    0.03    0.04    0.02    0.02    0.00    0.03    0.00    0.03    0.02    0.03    0.00    0.15    0.00    0.13    0.02    0.05    0.00    0.04    0.00    0.00    0.01    0.07    0.14    0.04    0.00    0.03    0.06    0.02    0.06    0.18    0.06    0.36    0.00    0.02    0.00    0.02    0.00    0.06    0.00    0.01    0.00    0.07    0.00    0.00    0.00    0.05  
OR4C6ENSG00000181903  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR4P4ENSG00000181927  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
PRKAG1ENSG00000181929  0.00    0.00    0.00    0.00    0.00    0.00    0.00    0.00    0.03    0.04    0.00    0.00    0.00    0.04    0.06    0.01    0.04    0.02    0.01    0.05    0.06    0.07    0.04    0.04    0.02    0.00    0.02    0.01    0.00    0.05    0.02    0.01    0.09    0.01    0.16    0.01    0.00    0.03    0.00    0.00    0.05    0.05    0.08    0.07    0.02    0.01    0.03    0.01    0.09    0.11    0.07    0.09    0.02    0.00    0.00    0.01    0.10    0.06    0.01    0.04    0.02    0.05    0.00    0.00    0.06    0.04  
OR4C15ENSG00000181939  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR4A15ENSG00000181958  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR4A16ENSG00000181961  0.01    0.00    0.00    0.01    0.08    0.00    0.01    0.03    0.13    0.04    0.00    0.01    0.04    0.03    0.04    0.03    0.08    0.03    0.11    0.01    0.16    0.05    0.01    0.04    0.02    0.01    0.01    0.02    0.00    0.01    0.02    0.02    0.05    0.07    0.07    0.00    0.00    0.01    0.00    0.00    0.09    0.07    0.12    0.06    0.04    0.02    0.04    0.03    0.34    0.03    0.10    0.05    0.01    0.03    0.00    0.00    0.00    0.02    0.01    0.02    0.01    0.02    0.00    0.02    0.05    0.04  
OR52K2ENSG00000181963  0.00    0.00    0.00    0.00    0.00    0.03    0.00    0.02    0.01    0.09    0.00    0.00    0.02    0.05    0.02    0.06    0.02    0.14    0.01    0.07    0.02    0.10    0.01    0.05    0.01    0.01    0.01    0.02    0.00    0.05    0.04    0.03    0.03    0.04    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.11    0.02    0.44    0.01    0.05    0.02    0.06    0.03    0.09    0.05    0.14    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.10    0.01    0.05    0.00    0.00    0.01    0.03  
OR52A1ENSG00000182070  0.00    0.00    0.00    0.00    0.00    0.03    0.00    0.02    0.01    0.09    0.00    0.00    0.02    0.05    0.01    0.06    0.02    0.14    0.01    0.06    0.04    0.11    0.03    0.06    0.01    0.01    0.01    0.02    0.00    0.05    0.03    0.03    0.03    0.01    0.01    0.07    0.03    0.07    0.00    0.00    0.02    0.10    0.01    0.43    0.01    0.05    0.02    0.07    0.03    0.09    0.04    0.13    0.02    0.00    0.00    0.00    0.05    0.00    0.01    0.10    0.01    0.05    0.00    0.00    0.01    0.03  
OR6B2ENSG00000182083  0.01    0.08    0.04    0.05    0.00    0.05    0.01    0.04    0.00    0.33    0.00    0.02    0.00    0.04    0.06    0.05    0.03    0.19    0.01    0.18    0.03    0.16    0.03    0.10    0.02    0.03    0.03    0.04    0.04    0.04    0.03    0.09    0.05    0.01    0.05    0.12    0.00    0.01    0.00    0.01    0.02    0.11    0.20    0.29    0.02    0.38    0.03    0.06    0.13    0.09    0.09    0.46    0.03    0.05    0.00    0.00    0.00    0.00    0.00    0.14    0.00    0.04    0.01    0.08    0.01    0.17  
TNRC18ENSG00000182095  0.01    0.00    0.02    0.00    0.00    0.00    0.01    0.02    0.17    0.01    0.00    0.00    0.08    0.00    0.10    0.02    0.15    0.02    0.12    0.01    0.24    0.02    0.16    0.02    0.05    0.00    0.05    0.00    0.02    0.00    0.07    0.01    0.01    0.01    0.18    0.03    0.01    0.00    0.00    0.00    0.08    0.05    0.09    0.41    0.06    0.04    0.06    0.07    0.17    0.03    0.20    0.05    0.14    0.01    0.00    0.01    0.10    0.00    0.01    0.02    0.05    0.01    0.00    0.00    0.16    0.01  

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