Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| TP53RK | ENSG00000172315 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.14 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.09 | 0.01 | 0.00 | 0.01 | 0.05 | 0.00 | 0.16 | 0.00 | 0.15 | 0.00 | 0.15 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.15 | 0.02 | 0.27 | 0.04 | 0.02 | 0.04 | 0.10 | 0.01 | 0.33 | 0.00 | 0.10 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 |
| OR5A1 | ENSG00000172320 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.02 | 0.01 | 0.10 | 0.02 | 0.00 | 0.00 | 0.07 | 0.04 | 0.03 | 0.03 | 0.07 | 0.02 | 0.11 | 0.03 | 0.07 | 0.04 | 0.01 | 0.04 | 0.01 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.05 | 0.02 | 0.14 | 0.17 | 0.05 | 0.06 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 |
| OR5A2 | ENSG00000172324 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.02 | 0.01 | 0.10 | 0.02 | 0.00 | 0.00 | 0.07 | 0.04 | 0.03 | 0.03 | 0.07 | 0.02 | 0.11 | 0.03 | 0.07 | 0.04 | 0.01 | 0.04 | 0.01 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.11 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.04 | 0.02 | 0.14 | 0.17 | 0.05 | 0.05 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 |
| IL16 | ENSG00000172349 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.00 | 0.11 | 0.02 | 0.03 | 0.01 | 0.10 | 0.01 | 0.04 | 0.03 | 0.09 | 0.03 | 0.10 | 0.02 | 0.03 | 0.01 | 0.03 | 0.00 | 0.05 | 0.01 | 0.06 | 0.03 | 0.05 | 0.01 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.13 | 0.03 | 0.22 | 0.09 | 0.16 | 0.00 | 0.03 | 0.03 | 0.13 | 0.05 | 0.06 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.15 | 0.00 |
| ABCG4 | ENSG00000172350 | 0.01 | 0.01 | 0.00 | 0.05 | 0.02 | 0.02 | 0.02 | 0.08 | 0.04 | 0.12 | 0.00 | 0.00 | 0.11 | 0.04 | 0.06 | 0.08 | 0.05 | 0.09 | 0.04 | 0.16 | 0.05 | 0.12 | 0.06 | 0.07 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.09 | 0.00 | 0.17 | 0.03 | 0.05 | 0.00 | 0.05 | 0.00 | 0.00 | 0.02 | 0.22 | 0.17 | 0.14 | 0.04 | 0.31 | 0.06 | 0.05 | 0.11 | 0.17 | 0.04 | 0.22 | 0.00 | 0.15 | 0.03 | 0.01 | 0.11 | 0.02 | 0.06 | 0.01 | 0.03 | 0.01 | 0.01 | 0.07 | 0.00 | 0.26 |
| CDY1B | ENSG00000172352 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR5B12 | ENSG00000172362 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.02 | 0.14 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.04 | 0.07 | 0.02 | 0.11 | 0.02 | 0.14 | 0.04 | 0.00 | 0.04 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.10 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.06 | 0.01 | 0.16 | 0.13 | 0.06 | 0.05 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.09 | 0.02 |
| OR5B2 | ENSG00000172365 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.02 | 0.14 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.04 | 0.07 | 0.02 | 0.11 | 0.02 | 0.14 | 0.04 | 0.00 | 0.04 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.10 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.06 | 0.01 | 0.16 | 0.13 | 0.06 | 0.05 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.09 | 0.02 |
| OR9I1 | ENSG00000172377 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.15 | 0.02 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.04 | 0.08 | 0.02 | 0.11 | 0.02 | 0.13 | 0.04 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.12 | 0.04 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.12 | 0.07 | 0.11 | 0.05 | 0.05 | 0.02 | 0.06 | 0.02 | 0.24 | 0.11 | 0.06 | 0.03 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.09 | 0.03 |
| PRSS27 | ENSG00000172382 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.03 | 0.08 | 0.04 | 0.03 | 0.05 | 0.08 | 0.02 | 0.08 | 0.03 | 0.03 | 0.03 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.05 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.11 | 0.16 | 0.10 | 0.03 | 0.05 | 0.03 | 0.03 | 0.05 | 0.10 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.01 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 |
| INSL5 | ENSG00000172410 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.04 | 0.05 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.05 | 0.03 | 0.05 | 0.02 | 0.03 | 0.02 | 0.06 | 0.02 | 0.04 | 0.00 | 0.07 | 0.00 | 0.07 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.17 | 0.02 | 0.03 | 0.02 | 0.17 | 0.00 | 0.00 | 0.07 | 0.06 | 0.16 | 0.12 | 0.04 | 0.03 | 0.03 | 0.02 | 0.05 | 0.05 | 0.18 | 0.02 | 0.01 | 0.05 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.03 | 0.02 | 0.00 | 0.07 | 0.02 | 0.05 |
| OR9G4 | ENSG00000172457 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.02 | 0.14 | 0.03 | 0.00 | 0.00 | 0.06 | 0.05 | 0.03 | 0.03 | 0.09 | 0.02 | 0.13 | 0.01 | 0.12 | 0.03 | 0.01 | 0.04 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.06 | 0.12 | 0.05 | 0.07 | 0.01 | 0.04 | 0.02 | 0.28 | 0.13 | 0.10 | 0.04 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| IL17D | ENSG00000172458 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.05 | 0.08 | 0.07 | 0.00 | 0.00 | 0.00 | 0.14 | 0.01 | 0.13 | 0.02 | 0.14 | 0.01 | 0.19 | 0.05 | 0.11 | 0.10 | 0.05 | 0.20 | 0.00 | 0.31 | 0.02 | 0.00 | 0.01 | 0.06 | 0.11 | 0.00 | 0.15 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.08 | 0.07 | 0.21 | 0.03 | 0.16 | 0.01 | 0.06 | 0.02 | 0.26 | 0.17 | 0.18 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.06 | 0.02 | 0.06 | 0.00 | 0.00 | 0.07 | 0.06 |
| OR5AR1 | ENSG00000172459 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.02 | 0.14 | 0.03 | 0.00 | 0.00 | 0.06 | 0.05 | 0.03 | 0.03 | 0.09 | 0.02 | 0.12 | 0.01 | 0.19 | 0.03 | 0.01 | 0.04 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.12 | 0.05 | 0.06 | 0.02 | 0.04 | 0.02 | 0.28 | 0.08 | 0.10 | 0.04 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.03 |
| PRSS30P | ENSG00000172460 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.03 | 0.09 | 0.04 | 0.03 | 0.04 | 0.08 | 0.03 | 0.08 | 0.03 | 0.03 | 0.03 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.05 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.10 | 0.16 | 0.11 | 0.02 | 0.06 | 0.04 | 0.03 | 0.05 | 0.09 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 |
| OR5AP2 | ENSG00000172464 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.02 | 0.14 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 | 0.03 | 0.03 | 0.09 | 0.02 | 0.12 | 0.01 | 0.19 | 0.03 | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.06 | 0.12 | 0.05 | 0.06 | 0.02 | 0.04 | 0.02 | 0.28 | 0.08 | 0.09 | 0.04 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.03 |
| OR8J1 | ENSG00000172487 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.14 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 | 0.03 | 0.03 | 0.09 | 0.03 | 0.12 | 0.01 | 0.16 | 0.03 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.10 | 0.07 | 0.11 | 0.04 | 0.05 | 0.01 | 0.04 | 0.02 | 0.28 | 0.02 | 0.07 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.02 |
| OR5T3 | ENSG00000172489 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.00 | 0.01 | 0.01 | 0.15 | 0.03 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.03 | 0.08 | 0.02 | 0.11 | 0.01 | 0.16 | 0.03 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.12 | 0.05 | 0.05 | 0.01 | 0.04 | 0.02 | 0.28 | 0.02 | 0.10 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.02 |
| OR10H5 | ENSG00000172519 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.21 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.01 | 0.00 | 0.08 | 0.03 | 0.00 | 0.03 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.78 | 0.04 | 0.01 | 0.01 | 0.25 | 0.01 | 0.30 | 0.05 | 0.14 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 |
| MUCL1 | ENSG00000172551 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.07 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.01 | 0.04 | 0.02 | 0.01 | 0.02 | 0.05 | 0.03 | 0.06 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.02 | 0.02 | 0.01 | 0.17 | 0.01 | 0.30 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.05 | 0.16 | 0.04 | 0.06 | 0.00 | 0.04 | 0.01 | 0.14 | 0.09 | 0.21 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.01 | 0.04 | 0.05 | 0.04 | 0.08 | 0.00 | 0.03 | 0.05 |
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