Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 101 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| OR1L3 | ENSG00000171481 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.02 | 0.04 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.05 | 0.02 | 0.06 | 0.01 | 0.11 | 0.01 | 0.08 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.02 | 0.01 | 0.02 | 0.04 | 0.03 | 0.16 | 0.09 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 |
| SPACA5 | ENSG00000171489 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.05 | 0.02 | 0.03 | 0.03 | 0.03 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.16 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.35 | 0.07 | 0.03 | 0.03 | 0.11 | 0.01 | 0.24 | 0.03 | 0.11 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 |
| OR1L8 | ENSG00000171496 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.04 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.05 | 0.02 | 0.06 | 0.01 | 0.10 | 0.01 | 0.08 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.02 | 0.01 | 0.01 | 0.03 | 0.03 | 0.16 | 0.09 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 |
| PPID | ENSG00000171497 | 0.03 | 0.02 | 0.00 | 0.02 | 0.06 | 0.02 | 0.03 | 0.02 | 0.04 | 0.13 | 0.00 | 0.02 | 0.00 | 0.03 | 0.02 | 0.06 | 0.02 | 0.12 | 0.02 | 0.10 | 0.16 | 0.11 | 0.06 | 0.07 | 0.01 | 0.08 | 0.02 | 0.04 | 0.00 | 0.03 | 0.06 | 0.07 | 0.06 | 0.11 | 0.10 | 0.07 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.08 | 0.07 | 0.29 | 0.04 | 0.08 | 0.02 | 0.05 | 0.12 | 0.02 | 0.12 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.00 | 0.08 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.06 |
| OR1N2 | ENSG00000171501 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.04 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.05 | 0.02 | 0.06 | 0.01 | 0.10 | 0.01 | 0.08 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.02 | 0.01 | 0.01 | 0.03 | 0.03 | 0.16 | 0.09 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 |
| OR1N1 | ENSG00000171505 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.05 | 0.02 | 0.06 | 0.01 | 0.10 | 0.01 | 0.08 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.02 | 0.01 | 0.01 | 0.03 | 0.03 | 0.16 | 0.09 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 |
| PTGER4 | ENSG00000171522 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 | 0.12 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.22 | 0.01 | 0.23 | 0.00 | 0.10 | 0.00 | 0.22 | 0.01 | 0.21 | 0.01 | 0.05 | 0.01 | 0.05 | 0.00 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.22 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.06 | 0.02 | 0.24 | 0.02 | 0.06 | 0.00 | 0.07 | 0.01 | 0.16 | 0.03 | 0.26 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.12 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.13 | 0.02 |
| ECEL1 | ENSG00000171551 | 0.01 | 0.07 | 0.04 | 0.04 | 0.00 | 0.05 | 0.01 | 0.04 | 0.00 | 0.33 | 0.00 | 0.03 | 0.00 | 0.07 | 0.04 | 0.04 | 0.02 | 0.20 | 0.01 | 0.19 | 0.03 | 0.16 | 0.04 | 0.07 | 0.02 | 0.04 | 0.02 | 0.02 | 0.05 | 0.03 | 0.03 | 0.06 | 0.05 | 0.01 | 0.01 | 0.05 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.09 | 0.15 | 0.21 | 0.01 | 0.39 | 0.04 | 0.06 | 0.13 | 0.06 | 0.04 | 0.35 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.01 | 0.04 | 0.01 | 0.08 | 0.01 | 0.11 |
| OR2AT4 | ENSG00000171561 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.00 | 0.04 | 0.00 | 0.16 | 0.03 | 0.00 | 0.00 | 0.08 | 0.00 | 0.13 | 0.01 | 0.15 | 0.02 | 0.24 | 0.03 | 0.45 | 0.03 | 0.13 | 0.01 | 0.02 | 0.00 | 0.03 | 0.02 | 0.01 | 0.01 | 0.08 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.40 | 0.06 | 0.52 | 0.02 | 0.10 | 0.01 | 0.11 | 0.02 | 0.14 | 0.16 | 0.19 | 0.04 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.21 | 0.00 |
| PIK3CD | ENSG00000171608 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.06 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.07 | 0.06 | 0.06 | 0.12 | 0.05 | 0.09 | 0.09 | 0.11 | 0.09 | 0.08 | 0.01 | 0.14 | 0.00 | 0.21 | 0.04 | 0.07 | 0.03 | 0.27 | 0.00 | 1.10 | 0.03 | 0.21 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.19 | 0.25 | 0.35 | 0.04 | 0.09 | 0.08 | 0.11 | 0.16 | 0.25 | 0.18 | 0.22 | 0.08 | 0.11 | 0.02 | 0.01 | 0.00 | 0.07 | 0.00 | 0.05 | 0.04 | 0.23 | 0.00 | 0.10 | 0.06 | 0.12 |
| SLC25A33 | ENSG00000171612 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.06 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.06 | 0.06 | 0.06 | 0.11 | 0.05 | 0.08 | 0.09 | 0.09 | 0.09 | 0.08 | 0.01 | 0.14 | 0.00 | 0.21 | 0.03 | 0.07 | 0.05 | 0.26 | 0.00 | 1.10 | 0.03 | 0.22 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.19 | 0.25 | 0.34 | 0.04 | 0.10 | 0.06 | 0.11 | 0.13 | 0.29 | 0.17 | 0.21 | 0.08 | 0.11 | 0.02 | 0.01 | 0.00 | 0.07 | 0.00 | 0.05 | 0.02 | 0.25 | 0.00 | 0.10 | 0.06 | 0.12 |
| GPR82 | ENSG00000171657 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.06 | 0.01 | 0.02 | 0.06 | 0.00 | 0.05 | 0.03 | 0.06 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.12 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.10 | 0.00 | 0.03 | 0.01 | 0.02 | 0.13 | 0.06 | 0.12 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 |
| GPR34 | ENSG00000171659 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.06 | 0.01 | 0.02 | 0.06 | 0.00 | 0.04 | 0.03 | 0.06 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.12 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.10 | 0.00 | 0.03 | 0.01 | 0.02 | 0.13 | 0.06 | 0.12 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 |
| DEFB4A | ENSG00000171711 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.12 | 0.01 | 0.15 | 0.00 | 0.00 | 0.02 | 0.04 | 0.03 | 0.07 | 0.01 | 0.14 | 0.00 | 0.08 | 0.09 | 0.08 | 0.12 | 0.04 | 0.02 | 0.10 | 0.00 | 0.20 | 0.01 | 0.05 | 0.01 | 0.14 | 0.00 | 0.01 | 0.04 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.03 | 0.42 | 0.01 | 0.05 | 0.00 | 0.09 | 0.13 | 0.28 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| HDAC3 | ENSG00000171720 | 0.30 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.01 | 0.03 | 0.01 | 0.03 | 0.02 | 0.03 | 0.02 | 0.04 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 | 0.03 | 0.07 | 0.03 | 0.09 | 0.01 | 0.22 | 0.02 | 0.00 | 0.05 | 0.01 | 0.00 | 0.03 | 0.02 | 0.14 | 0.11 | 0.03 | 0.01 | 0.02 | 0.02 | 0.11 | 0.01 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.10 | 0.04 | 0.00 | 0.00 | 0.05 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 | 0.15 |
| ANGPTL7 | ENSG00000171819 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.00 | 0.06 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.26 | 0.06 | 0.06 | 0.05 | 0.11 | 0.04 | 0.08 | 0.14 | 0.08 | 0.11 | 0.08 | 0.01 | 0.12 | 0.00 | 0.21 | 0.03 | 0.06 | 0.03 | 0.25 | 0.00 | 1.07 | 0.03 | 0.21 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.19 | 0.21 | 0.36 | 0.04 | 0.10 | 0.09 | 0.10 | 0.04 | 0.27 | 0.18 | 0.20 | 0.08 | 0.09 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.04 | 0.05 | 0.13 | 0.00 | 0.07 | 0.06 | 0.11 |
| IFNB1 | ENSG00000171855 | 0.00 | 0.02 | 0.00 | 0.05 | 0.00 | 0.06 | 0.01 | 0.03 | 0.10 | 0.34 | 0.00 | 0.04 | 0.00 | 0.57 | 0.03 | 0.25 | 0.05 | 0.31 | 0.06 | 0.15 | 0.03 | 0.27 | 0.02 | 0.16 | 0.02 | 0.02 | 0.01 | 0.02 | 0.03 | 0.25 | 0.00 | 0.08 | 0.00 | 0.16 | 0.00 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.06 | 0.07 | 0.08 | 0.17 | 0.06 | 0.05 | 0.04 | 0.02 | 0.04 | 0.05 | 0.08 | 0.22 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.20 | 0.01 | 0.86 | 0.00 | 0.00 | 0.02 | 0.28 |
| PRNP | ENSG00000171867 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.03 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.04 | 0.11 | 0.01 | 0.03 | 0.03 | 0.07 | 0.03 | 0.06 | 0.01 | 0.05 | 0.04 | 0.05 | 0.09 | 0.00 | 0.03 | 0.03 | 0.01 | 0.00 | 0.03 | 0.09 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.05 | 0.27 | 0.07 | 0.05 | 0.01 | 0.07 | 0.02 | 0.06 | 0.06 | 0.07 | 0.09 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 |
| OR10H3 | ENSG00000171936 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.22 | 0.01 | 0.05 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.01 | 0.00 | 0.09 | 0.03 | 0.00 | 0.03 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.78 | 0.03 | 0.01 | 0.01 | 0.24 | 0.01 | 0.30 | 0.05 | 0.15 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 |
| OR10H2 | ENSG00000171942 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.02 | 0.10 | 0.02 | 0.06 | 0.01 | 0.22 | 0.01 | 0.05 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.01 | 0.00 | 0.09 | 0.03 | 0.00 | 0.03 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.78 | 0.04 | 0.01 | 0.01 | 0.25 | 0.01 | 0.32 | 0.05 | 0.15 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 |
|
Showing page 101 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.