Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| FPR1 | ENSG00000171051 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.16 | 0.03 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.07 | 0.07 | 0.09 | 0.03 | 0.02 | 0.06 | 0.04 | 0.11 | 0.04 | 0.02 | 0.03 | 0.01 | 0.03 | 0.03 | 0.05 | 0.04 | 0.03 | 0.00 | 0.07 | 0.23 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.15 | 0.03 | 0.11 | 0.31 | 0.08 | 0.07 | 0.04 | 0.06 | 0.21 | 0.11 | 0.04 | 0.20 | 0.00 | 0.06 | 0.01 | 0.00 | 0.13 | 0.03 | 0.01 | 0.16 | 0.03 | 0.14 | 0.00 | 0.00 | 0.04 | 0.03 |
| OR13H1 | ENSG00000171054 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.05 | 0.04 | 0.05 | 0.01 | 0.05 | 0.02 | 0.09 | 0.02 | 0.09 | 0.02 | 0.05 | 0.01 | 0.10 | 0.02 | 0.11 | 0.02 | 0.03 | 0.00 | 0.05 | 0.02 | 0.01 | 0.00 | 0.09 | 0.03 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.20 | 0.05 | 0.09 | 0.01 | 0.02 | 0.01 | 0.04 | 0.10 | 0.03 | 0.14 | 0.00 | 0.02 | 0.00 | 0.00 | 0.07 | 0.05 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 |
| OBP2B | ENSG00000171102 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.05 | 0.02 | 0.07 | 0.02 | 0.06 | 0.03 | 0.12 | 0.04 | 0.13 | 0.01 | 0.02 | 0.01 | 0.05 | 0.03 | 0.01 | 0.00 | 0.05 | 0.03 | 0.06 | 0.01 | 0.12 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.07 | 0.24 | 0.07 | 0.01 | 0.03 | 0.06 | 0.04 | 0.14 | 0.05 | 0.14 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 |
| NRTN | ENSG00000171119 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.03 | 0.03 | 0.10 | 0.00 | 0.01 | 0.01 | 0.09 | 0.01 | 0.06 | 0.04 | 0.09 | 0.04 | 0.10 | 0.02 | 0.11 | 0.01 | 0.07 | 0.02 | 0.03 | 0.02 | 0.07 | 0.00 | 0.06 | 0.03 | 0.12 | 0.00 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.08 | 0.12 | 0.60 | 0.03 | 0.17 | 0.01 | 0.22 | 0.02 | 0.56 | 0.19 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.07 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.05 | 0.04 | 0.03 |
| ATP6V0E2 | ENSG00000171130 | 0.03 | 0.01 | 0.06 | 0.00 | 0.05 | 0.02 | 0.03 | 0.02 | 0.04 | 0.05 | 0.00 | 0.01 | 0.00 | 0.04 | 0.09 | 0.02 | 0.09 | 0.08 | 0.02 | 0.16 | 0.05 | 0.25 | 0.02 | 0.10 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.04 | 0.00 | 0.11 | 0.03 | 0.06 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.07 | 0.55 | 0.07 | 0.03 | 0.09 | 0.03 | 0.05 | 0.07 | 0.19 | 0.12 | 0.14 | 0.01 | 0.05 | 0.00 | 0.06 | 0.02 | 0.11 | 0.11 | 0.01 | 0.06 | 0.01 | 0.00 | 0.03 | 0.20 | 0.03 |
| OR2K2 | ENSG00000171133 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.05 | 0.05 | 0.00 | 0.00 | 0.02 | 0.02 | 0.05 | 0.02 | 0.05 | 0.01 | 0.05 | 0.00 | 0.09 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.03 | 0.04 | 0.06 | 0.04 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.05 | 0.09 | 0.12 | 0.02 | 0.01 | 0.01 | 0.03 | 0.00 | 0.15 | 0.10 | 0.01 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.01 |
| RLN3 | ENSG00000171136 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.02 | 0.05 | 0.00 | 0.00 | 0.06 | 0.02 | 0.00 | 0.05 | 0.12 | 0.04 | 0.07 | 0.02 | 0.12 | 0.05 | 0.05 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 | 0.02 | 0.07 | 0.05 | 0.00 | 0.03 | 0.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.03 | 0.86 | 0.07 | 0.09 | 0.01 | 0.21 | 0.02 | 0.21 | 0.11 | 0.25 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 |
| OR2M4 | ENSG00000171180 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.04 | 0.14 | 0.04 | 0.02 | 0.02 | 0.08 | 0.05 | 0.13 | 0.01 | 0.17 | 0.03 | 0.10 | 0.02 | 0.27 | 0.04 | 0.13 | 0.01 | 0.04 | 0.02 | 0.08 | 0.01 | 0.02 | 0.01 | 0.20 | 0.02 | 0.23 | 0.02 | 0.10 | 0.07 | 0.00 | 0.04 | 0.00 | 0.00 | 0.29 | 0.02 | 0.48 | 0.12 | 0.13 | 0.01 | 0.12 | 0.02 | 0.32 | 0.00 | 0.09 | 0.24 | 0.06 | 0.02 | 0.01 | 0.00 | 0.03 | 0.18 | 0.02 | 0.04 | 0.02 | 0.04 | 0.15 | 0.03 | 0.24 | 0.02 |
| GRIK1 | ENSG00000171189 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.05 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.06 | 0.04 | 0.05 | 0.01 | 0.05 | 0.03 | 0.06 | 0.01 | 0.03 | 0.01 | 0.03 | 0.01 | 0.09 | 0.00 | 0.01 | 0.01 | 0.05 | 0.00 | 0.03 | 0.10 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.11 | 0.11 | 0.02 | 0.04 | 0.02 | 0.01 | 0.03 | 0.05 | 0.12 | 0.07 | 0.01 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.03 | 0.01 |
| MUC7 | ENSG00000171195 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.10 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.08 | 0.03 | 0.21 | 0.01 | 0.08 | 0.01 | 0.10 | 0.04 | 0.05 | 0.03 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.01 | 0.02 | 0.07 | 0.00 | 0.03 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.02 | 0.24 | 0.09 | 0.04 | 0.04 | 0.04 | 0.01 | 0.13 | 0.05 | 0.07 | 0.05 | 0.10 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 |
| SMR3B | ENSG00000171201 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 | 0.10 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.08 | 0.03 | 0.21 | 0.01 | 0.08 | 0.02 | 0.10 | 0.02 | 0.05 | 0.03 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.01 | 0.02 | 0.07 | 0.00 | 0.08 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.11 | 0.02 | 0.24 | 0.08 | 0.04 | 0.04 | 0.04 | 0.01 | 0.10 | 0.05 | 0.07 | 0.06 | 0.10 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 |
| CSN3 | ENSG00000171209 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.10 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.07 | 0.03 | 0.21 | 0.01 | 0.08 | 0.02 | 0.10 | 0.02 | 0.05 | 0.03 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.01 | 0.02 | 0.08 | 0.00 | 0.03 | 0.06 | 0.00 | 0.03 | 0.03 | 0.00 | 0.00 | 0.11 | 0.02 | 0.25 | 0.08 | 0.04 | 0.04 | 0.04 | 0.02 | 0.10 | 0.05 | 0.07 | 0.05 | 0.09 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 |
| LRG1 | ENSG00000171236 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.04 | 0.01 | 0.04 | 0.03 | 0.12 | 0.00 | 0.01 | 0.01 | 0.10 | 0.01 | 0.08 | 0.04 | 0.12 | 0.03 | 0.11 | 0.04 | 0.13 | 0.00 | 0.10 | 0.01 | 0.05 | 0.06 | 0.09 | 0.00 | 0.06 | 0.03 | 0.13 | 0.00 | 0.03 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.11 | 0.04 | 0.79 | 0.03 | 0.18 | 0.01 | 0.27 | 0.08 | 0.71 | 0.15 | 0.07 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.05 | 0.04 | 0.04 |
| SOSTDC1 | ENSG00000171243 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.23 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.10 | 0.01 | 0.12 | 0.01 | 0.08 | 0.01 | 0.17 | 0.02 | 0.07 | 0.01 | 0.05 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.05 | 0.02 | 0.00 | 0.01 | 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.13 | 0.29 | 0.03 | 0.01 | 0.05 | 0.03 | 0.12 | 0.09 | 0.16 | 0.04 | 0.09 | 0.01 | 0.00 | 0.01 | 0.03 | 0.06 | 0.00 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.12 | 0.02 |
| KCND3 | ENSG00000171385 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.35 | 0.01 | 0.14 | 0.02 | 0.15 | 0.00 | 0.14 | 0.04 | 0.13 | 0.03 | 0.07 | 0.00 | 0.07 | 0.05 | 0.08 | 0.00 | 0.02 | 0.01 | 0.04 | 0.00 | 0.10 | 0.02 | 0.05 | 0.00 | 0.25 | 0.00 | 0.00 | 0.03 | 0.10 | 0.16 | 0.15 | 0.02 | 0.08 | 0.01 | 0.03 | 0.04 | 0.07 | 0.03 | 0.12 | 0.04 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.00 | 0.01 | 0.01 | 0.03 | 0.03 | 0.03 | 0.07 | 0.10 |
| APLN | ENSG00000171388 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.05 | 0.05 | 0.05 | 0.01 | 0.03 | 0.02 | 0.10 | 0.02 | 0.08 | 0.02 | 0.06 | 0.01 | 0.11 | 0.02 | 0.13 | 0.01 | 0.03 | 0.00 | 0.05 | 0.01 | 0.01 | 0.00 | 0.09 | 0.03 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.18 | 0.05 | 0.08 | 0.00 | 0.02 | 0.01 | 0.08 | 0.08 | 0.03 | 0.14 | 0.01 | 0.02 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 |
| NAT1 | ENSG00000171428 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.19 | 0.00 | 0.14 | 0.00 | 0.00 | 0.02 | 0.03 | 0.01 | 0.06 | 0.01 | 0.09 | 0.00 | 0.07 | 0.07 | 0.05 | 0.08 | 0.03 | 0.00 | 0.12 | 0.00 | 0.18 | 0.00 | 0.05 | 0.01 | 0.12 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.13 | 0.02 | 0.40 | 0.01 | 0.03 | 0.01 | 0.08 | 0.11 | 0.18 | 0.05 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.01 | 0.05 |
| POLR1C | ENSG00000171453 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.21 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.10 | 0.01 | 0.17 | 0.04 | 0.07 | 0.02 | 0.58 | 0.01 | 0.38 | 0.01 | 0.10 | 0.00 | 0.21 | 0.00 | 0.04 | 0.00 | 0.17 | 0.01 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.13 | 0.03 | 0.28 | 0.07 | 0.07 | 0.02 | 0.07 | 0.01 | 0.14 | 0.03 | 0.12 | 0.02 | 0.05 | 0.01 | 0.00 | 0.00 | 0.09 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.07 | 0.00 |
| OR1L6 | ENSG00000171459 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.02 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.04 | 0.02 | 0.05 | 0.02 | 0.06 | 0.01 | 0.11 | 0.01 | 0.08 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.11 | 0.15 | 0.02 | 0.01 | 0.02 | 0.03 | 0.03 | 0.16 | 0.09 | 0.04 | 0.02 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| SPACA5B | ENSG00000171478 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.05 | 0.02 | 0.02 | 0.03 | 0.03 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.16 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.38 | 0.07 | 0.03 | 0.03 | 0.12 | 0.01 | 0.24 | 0.03 | 0.11 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 |
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